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Development of nucleic acid therapy using rapid acting DDS

Research Project

Project/Area Number 15H04920
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

YAMAMOTO Hirofumi  大阪大学, 医学系研究科, 教授 (30322184)

Co-Investigator(Kenkyū-buntansha) 森 正樹  大阪大学, 医学系研究科, 教授 (70190999)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywordsドラッグデリバリーシステム / 核酸医療 / 核酸治療 / KRAS変異 / 大腸癌 / 光治療 / ICG / バイオテクノロジー / DDS / 癌治療 / 抗癌剤 / 膵癌 / 核酸 / 消化器癌 / 動物モデル / 全身デリバリー / マイクロRNA
Outline of Final Research Achievements

Super carbonate apatite particles incorporating miR-29b-1-5p was effective to pancreatic cancer cells, while miR-4689 was not so effective to pancreatic cancer cells. sCA could lower interstitial fluid pressure (IFP) at the tumor stroma via integrin mediated mechanism. EPR related molecules hydroxyperoxidase, TNF α, nicotine were also affected. This led to efficient accumulation of anti-tumor agents or light sensitizer ICG in the tumor tissues by sCA injection alone. sCA-ICG is thought to be a good candidate for the photodynamic therapy. PEGylation of sCA did not realize improvement of stealth effect or increased tumor uptake. Finally we could make up a novel DDS device that does not accumulate in liver, yet does accumulate abundantly in tumor only with 10% amount of nucleic acid when compared to sCA. This would facilitate nucleic acid medicine in near future.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Photodynamic Therapy Using Indocyanine Green Loaded on Super Carbonate Apatite as Minimally Invasive Cancer Treatment2018

    • Author(s)
      Tamai Koki、Mizushima Tsunekazu、Wu Xin、Inoue Akira、Ota Minori、Yokoyama Yuhki、Miyoshi Norikatsu、Haraguchi Naotsugu、Takahashi Hidekazu、Nishimura Junichi、Hata Taishi、Matsuda Chu、Doki Yuichiro、Mori Masaki、Yamamoto Hirofumi
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: in press Issue: 7 Pages: 1613-1622

    • DOI

      10.1158/1535-7163.mct-17-0788

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling inKRAS-Mutant Colon Cancer Cells2018

    • Author(s)
      Inoue Akira、Mizushima Tsunekazu、Wu Xin、Okuzaki Daisuke、Kambara Nanami、Ishikawa Sho、Wang Jiaqi、Qian Yamin、Hirose Haruka、Yokoyama Yuhki、Ikeshima Ryo、Hiraki Masayuki、Miyoshi Norikatsu、Takahashi Hidekazu、Haraguchi Naotsugu、Hata Taishi、Matsuda Chu、Doki Yuichiro、Mori Masaki、Yamamoto Hirofumi
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: in press Issue: 5 Pages: 977-987

    • DOI

      10.1158/1535-7163.mct-17-0850

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 低侵襲治療としての大腸癌に対するICG光線力学療法2018

    • Author(s)
      武田 昂樹、畑 泰司、玉井 皓己、太田 みのり、 横山 雄起、高橋 秀和、三吉 範克、原口 直紹、 松田 宙、水島 恒和、土岐 祐一郎、森 正樹、 山本 浩文
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] super carbonate apatiteを使用したICG光線力学療法の検討2017

    • Author(s)
      玉井 皓己、高橋 秀和、原口 直紹、太田 みのり、 西村 潤一、畑 泰司、松田 宙、水島 恒和、土岐 祐一郎、 森 正樹、山本 浩文
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 卓越したin vivo腫瘍デリバリーを達成する新規DDSのメカニズム解析2016

    • Author(s)
      Hirofumi Yamamoto
    • Organizer
      第75回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Invited

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Published: 2015-04-16   Modified: 2019-12-27  

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