Breakthrough in clinical application and optimization of ghrelin administration by clarifying the mechanism of alleviating surgical stress
| Project/Area Number |
15H04930
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
Doki Yuichiro 大阪大学, 医学系研究科, 教授 (20291445)
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| Co-Investigator(Kenkyū-buntansha) |
瀧口 修司 名古屋市立大学, 大学院医学研究科, 教授 (00301268)
宮崎 安弘 大阪大学, 医学系研究科, 助教 (00571390)
黒川 幸典 大阪大学, 医学系研究科, 助教 (10470197)
山崎 誠 大阪大学, 医学系研究科, 准教授 (50444518)
高橋 剛 大阪大学, 医学部附属病院, その他 (50452389)
柳本 喜智 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 消化器外科医長 (70645085)
宮田 博志 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 副部長 (80362713)
牧野 知紀 大阪大学, 医学部附属病院, その他 (80528620)
新野 直樹 大阪大学, 医学部附属病院, 医員 (10724122)
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| Co-Investigator(Renkei-kenkyūsha) |
KANGAWA Kenji 独立行政法人国立循環器病研究センター (00112417)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | グレリン / 抗炎症 / 手術侵襲 / 高齢者 / 抗炎症効果 |
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| Outline of Final Research Achievements |
Basic research revealed that DAMP model would befit the animal model for targeting the anti-inflammatory mechanism of ghrelin rather than the LPS model which showed remarkable high IL-6 concentration in blood. With regard to human researches, we started the two clinical randomized trial of continuous ghrelin administration. One is for patients with esophagectomy and the other is for geriatric patients with total gastrectomy. These trials could optimize the method of ghrelin administration for exerting the anti-inflammatory effect. The last achievement of this study was identifying the association between active ghrelin concentration and the value of choline-esterase, which corresponded to liver function and obesity.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Plasma ghrelin suppression as an early predictor for postoperative complications after pancreatoduodenectomy.2018
Author(s)
Sasaki K, Asaoka T, Eguchi H, Fukuda Y, Iwagami Y, Yamada D, Miyazaki Y, Noda T, Takahashi T, Gotoh K, Kawamoto K, Kurokawa Y, Kobayashi S, Takiguchi S, Mori M, Doki Y.
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Journal Title
Pancreatology.
Volume: 18
Issue: 1
Pages: 73-78
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial.2016
Author(s)
Yanagimoto Y, Takiguchi S, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Hosoda H, Kangawa K, Mori M, Doki Y
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Journal Title
Br J Cancer
Volume: 114
Issue: 12
Pages: 1318-1325
DOI
Related Report
Peer Reviewed
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[Journal Article] Plasma ghrelin levels as a predictor of adverse renal events due to cisplatin-based chemotherapy in patients with esophageal cancer.2016
Author(s)
Yanagimoto Y, Takiguchi S, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Mori M, Doki Y
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Journal Title
Jpn J Clin Oncol.
Volume: 46
Issue: 5
Pages: 421-426
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of synthetic ghrelin administration for patients with severe body weight reduction more than 1 year after gastrectomy: a phase II clinical trial.2016
Author(s)
Takiguchi S, Miyazaki Y, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Miyata H, Hosoda H, Kangawa K, Mori M, Doki Y.
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Journal Title
Surg Today
Volume: 46
Issue: 3
Pages: 379-385
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of ghrelin administration on the early postoperative inflammatory response after esophagectomy.2015
Author(s)
Takata A, Takiguchi S, Murakami K, Miyazaki Y, Miyata H, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Mori M, Kangawa K, Doki Y.
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Journal Title
Surg Today.
Volume: 45
Issue: 8
Pages: 1025-1031
DOI
Related Report
Peer Reviewed
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[Journal Article] Randomized Phase II Study of the Anti-inflammatory Effect of Ghrelin During the Postoperative Period of Esophagectomy.2015
Author(s)
Takata A, Takiguchi S, Miyazaki Y, Miyata H, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Mori M, Kangawa K, Doki Y.
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Journal Title
Ann Surg
Volume: 262
Issue: 2
Pages: 230-236
DOI
Related Report
Peer Reviewed
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[Presentation] 癌治療における六君子湯の役割～グレリンに対する作用から臨床への応用～ 消化器外科の立場から－胃切除後消化器関連合併症に対する六君子湯投与の影響－2016
Author(s)
宮崎安弘, 新野直樹, 額原敦, 黒川幸典, 高橋剛, 山崎誠, 牧野知紀, 瀧口修司, 中島清一, 森正樹, 土岐祐一郎
Organizer
第54回日本癌治療学会学術集会
Place of Presentation
横浜(パシフィコ横浜)
Related Report
Invited
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