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Comprehensive analysis of factors related to functional recovery of severe heart failure by surgical unloading

Research Project

Project/Area Number 15H04936
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cardiovascular surgery
Research InstitutionChiba University

Principal Investigator

MATSUMIYA Goro  千葉大学, 大学院医学研究院, 教授 (20314312)

Co-Investigator(Kenkyū-buntansha) 石田 敬一  千葉大学, 大学院医学研究院, 特任准教授 (40375671)
上田 秀樹  千葉大学, 医学部附属病院, 講師 (50738987)
黄野 皓木  千葉大学, 医学部附属病院, 助教 (40375803)
松浦 馨  千葉大学, 医学部附属病院, 助教 (50436375)
田村 友作  千葉大学, 医学部附属病院, 助教 (60738988)
渡邉 倫子  千葉大学, 医学部附属病院, 助教 (20766274)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords心不全 / 心筋症 / リモデリング / 補助人工心臓
Outline of Final Research Achievements

We sought to examine whether RNA sequencing of myocardial tissue samples can identify any useful factor to predict reverse remodeling of left ventricle in response to optimal medical management. Dilated cardiomyopathy patients with LVEF below 30% and NYHA class III or IV symptoms were analyzed. No difference were found in preoperative clinical parameters. RNA sequencing identified upregulated genes in non-reverse remodeling group, which encode mitochondrial respiratory chain complex and proteins involved p38 MAP kinase dependent cell death.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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