| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
We are developing a novel tissue-engineered heart valve (biovalve) with a unique in-body tissue engineering. In this study, the feasibility and time-course histological change after implantation were investigated in large animal experiments. Two types of biovalves (a full-root type and a stent valve for transcatheter implantation) were developed. The biovalve consists of completely autologous connective tissues and fibroblasts. The full-root type was implanted in the pulmonary artery, and the stent-valve type was implanted with transcatheter technique into in situ the aorta or the pulmonary artery. Successfully implanted biovalves reached to maximum 43 months. Histological examination showed the autologous cells covering the laminar surface of the valve leaflets and also repopulating into the connective tissues. The biovalves can adapt their histological structure to the environment, and have a potential to be used for viable bioprosthesis.
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