| Project/Area Number |
15H04949
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
横井 俊浩 滋賀医科大学, 医学部, 助教 (20573182)
椎野 顯彦 滋賀医科大学, 神経難病研究センター, 准教授 (50215935)
中村 紳一朗 滋賀医科大学, 動物生命科学研究センター, 准教授 (50307980)
地藤 純哉 滋賀医科大学, 医学部, 非常勤講師 (50534161)
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| Co-Investigator(Renkei-kenkyūsha) |
AOKI Tomohiro 京都大学, 大学院医学研究科, 研究員 (40633144)
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| Research Collaborator |
TSUJI Keiichi
MIYATA Haruka
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | cerebral aneurysm / animal model / MR imaging / medical treatment / 脳動脈瘤 / 炎症 / イメージング / 脳神経疾患 / 動物モデル / マクロファージ / プロスタグランジン / MRイメージング / MR |
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| Outline of Final Research Achievements |
Cerebral aneurysms (CAs) is a common disease in general public with prevalence between 1% and 5%, and subarachnoid hemorrhage (SAH) mostly caused by rupture of CAs is still a serious disease. In this project, we established and modified rat and monkey ecerbral aneurysmal models including a rupture model, analyzed critical cell and molecular candidates for cerebral aneurysmal development, tried to develop MR imaging systems using specific contrast medium for detection of rupture-prone cerebral aneurysms and set a live imaging to observe a real-time alteration in rat cerebral aneurysms. We also tested several possible medical treatments to stabilize cerebral aneurysms in animal models.
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