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Elucidation of blood flow control mechanisms for establishing a wide area of simulator of brain circulation after cerebral revascularization

Research Project

Project/Area Number 15H04952
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurosurgery
Research InstitutionKyoto University (2017)
National Cardiovascular Center Research Institute (2015-2016)

Principal Investigator

Hiroharu Kataoka  京都大学, 医学研究科, 講師 (40359815)

Co-Investigator(Kenkyū-buntansha) 八木 高伸  早稲田大学, 理工学術院, 客員主任研究員(研究院客員准教授) (00468852)
中村 匡徳  名古屋工業大学, 工学(系)研究科(研究院), 教授 (20448046)
宮本 享  京都大学, 医学研究科, 教授 (70239440)
梅津 光生  早稲田大学, 理工学術院, 教授 (90132927)
高橋 淳  国立研究開発法人国立循環器病研究センター, 病院, 部長 (90551408)
樋口 隆弘  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (30739850)
飯田 秀博  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (30322720)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywordsバイパス術 / 数値流体力学 / 脳動脈瘤 / 虚血性脳血管障害 / 脳血管疾患 / 脳血行再建術 / シミュレーション / 流体工学 / 脳神経疾患 / 流体力学 / 脳神経疾疾患
Outline of Final Research Achievements

Cerebral revascularization is an established surgical treatment for intracranial aneurysm and ischemic cerebrovascular disease. However, one problem of this treatment is that we cannot predict the postoperative hemodynamics. In this study, we have integrated the measurement of blood flow in intracranial arteries by phase contrast MRI, measurement of cereral blood flow by PET/SEPCT and computationla fluid dynamics (CFD), and have clarified a part of mechanisms of local vascular adjustment and redistribution of cerebral blood flow after revascularization surgery. Results of this study will lead to the development of a simulator for cerebral blood flow in the whole brain area which predicts postoperative hemodynamics, and will contribute to the improvement of treatment results after revascularization surgery.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (11 results)

  • [Journal Article] Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms.2018

    • Author(s)
      Ikedo T, Minami M, Kataoka H, Hayashi K, Nagata M, Fujikawa R, Yamazaki F, Setou M, Yokode M, Miyamoto S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 495 Pages: 332-338

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between reduction in microvascular transit time after superficial temporal artery-middle cerebral artery bypass surgery for moyamoya disease and the development of postoperative hyperperfusion syndrome2018

    • Author(s)
      Yang Tao、Higashino Yoshifumi、Kataoka Hiroharu、Hamano Eika、Maruyama Daisuke、Iihara Koji、Takahashi Jun C.
    • Journal Title

      Journal of Neurosurgery

      Volume: 128 Issue: 5 Pages: 1304-1310

    • DOI

      10.3171/2016.11.jns162403

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dipeptidyl Peptidase‐4 Inhibitor Anagliptin Prevents Intracranial Aneurysm Growth by Suppressing Macrophage Infiltration and Activation2017

    • Author(s)
      Ikedo Taichi、Minami Manabu、Kataoka Hiroharu、Hayashi Kosuke、Nagata Manabu、Fujikawa Risako、Higuchi Sei、Yasui Mika、Aoki Tomohiro、Fukuda Miyuki、Yokode Masayuki、Miyamoto Susumu
    • Journal Title

      Journal of the American Heart Association

      Volume: 6 Issue: 6

    • DOI

      10.1161/jaha.116.004777

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ICA blood blister-like aneurysmの治療戦略2018

    • Author(s)
      片岡大治
    • Organizer
      第47回日本脳卒中の外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phase Contrast MRIとMRI単純撮影を用いた脳血流量と脳組織血液需要の関係性の検討2018

    • Author(s)
      岡田明大
    • Organizer
      第47回日本脳卒中の外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phase Contrast MRIとMRI単純撮影を用いた脳血流量と脳組織血液需要の関係性の検討2017

    • Author(s)
      牧野恭秀
    • Organizer
      第46回日本脳卒中の外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Phase Contrast MRIとMRI単純撮影を用いた脳血流量と脳組織血液需要の関係性の検討2017

    • Author(s)
      岡田明大
    • Organizer
      第76回日本脳神経外科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳動脈瘤に対するバイパス併用治療2017

    • Author(s)
      片岡大治
    • Organizer
      第76回日本脳神経外科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳血管バイパス手術による末梢血管抵抗変化に対する流体力学的解釈2017

    • Author(s)
      中村匡徳
    • Organizer
      2017年度機械学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phase Contrast MRIを用いた動脈瘤治療支援バイパス術前後の血行動態の評価2016

    • Author(s)
      片岡大治
    • Organizer
      第28回日本脳循環代謝学会総会
    • Place of Presentation
      徳島
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Phase Contrast MRIを用いた動脈瘤治療支援バイパス術前後の血行動態の評価2016

    • Author(s)
      牧野恭秀
    • Organizer
      第75回日本脳神経外科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Phase Contrast MRIを用いた脳血管バイパス術前後の血行動態の評価2016

    • Author(s)
      片岡大治
    • Organizer
      第45回日本脳卒中の外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Phase Contrast MRIを用いたEC-ICバイパス術前後の脳血流量の測定2016

    • Author(s)
      牧野恭秀
    • Organizer
      第45回日本脳卒中の外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Phase Contrast MRIを用いた脳動脈瘤に対するバイパス併用術前後の血行動態の評価2015

    • Author(s)
      牧野恭秀
    • Organizer
      第74回日本脳神経外科学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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