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Development of novel therapeutic strategies for bone and soft tissue tumors

Research Project

Project/Area Number 15H04964
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionJuntendo University

Principal Investigator

Suehara Yoshiyuki  順天堂大学, 医学部, 准教授 (70509405)

Co-Investigator(Kenkyū-buntansha) 小林 英介  国立研究開発法人国立がん研究センター, 中央病院, 医長 (40365292)
北野 滋久  国立研究開発法人国立がん研究センター, 中央病院, 医員 (60402682)
齋藤 剛  順天堂大学, 医学部, 准教授 (80439736)
窪田 大介  順天堂大学, 医学部, 助教 (70638197)
Research Collaborator KOHSAKA Shinji  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords骨軟部腫瘍 / 骨軟部肉腫 / プロテオミクス / 融合遺伝子 / チロシンキナーゼ / 免疫応答 / がんクリニカルシークエンス / タンパク質発現解析 / 小胞体ストレス / 遺伝子変異 / 遺伝子変異解析 / チロシンキナーゼ阻害剤
Outline of Final Research Achievements

Our research projects conducted comprehensive researches harboring the proteomics, genomics, molecular pathogenesis and immune response of bone and soft tissue sarcomas, with an emphasis on the clinical translation of potential diagnostic markers and therapeutic targets.
In this study, we focused on some of t our main projects as follows: (1) Proteomic analyses of bone and soft tissue tumors, (2) The identification of novel tyrosine kinase mutations in lung cancer, (3) Immune response analyses of bone and soft tissue tumors. In this study, We successfully identified several novel therapeutic targets and biomarkers. We think that these identified gene and proteins may be useful for clinical application in the setting of bone and soft tissue tumors.

Academic Significance and Societal Importance of the Research Achievements

本研究は、難治性かつ「希少癌」である骨軟部腫瘍の生命予後の改善を目的として、治療成績向上の要となる腫瘍発生・悪性化・治療抵抗の原因因子を特定し、その結果に基づいた新規バイオマーカーや治療標的の開発を進めた。具体的には症例試料の確保、そして他癌で成功を収めている最新研究手法((1)組織型特異的融合遺伝子のタンパク質発現解明、
(2)免疫応答解析による免疫担当細胞プロファイリング、(3) TK阻害剤などが奏効するTK遺伝子変異の探索)を取り入れて研究を推進することで新規治療法開発を行い、希少癌患者の生命予後改善を試みた。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (64 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (4 results) Journal Article (33 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 33 results,  Open Access: 31 results,  Acknowledgement Compliant: 13 results) Presentation (27 results) (of which Int'l Joint Research: 24 results,  Invited: 5 results)

  • [Int'l Joint Research] Memorial Sloan Kettering Cancer Center/Department of Pathology/Marc Ladanyi(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] メモリアルスローンケタリングがんセンター(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Memorial Sloan-Kettering Cancer Center(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens2019

    • Author(s)
      Kohsaka Shinji、Tatsuno Kenji、Ueno Toshihide、et al.
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 4 Pages: 1464-1479

    • DOI

      10.1111/cas.13968

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multicenter experience with large panel next-generation sequencing in patients with advanced solid cancers in Japan.2019

    • Author(s)
      Kato S, Hayashi T, Suehara Y, Hamanoue H, Yamanaka S, Ichikawa Y, Higurashi T, Ohashi K, Yamaguchi S, Nozaki Y, Terao Y, Saito T.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 49(2) Issue: 2 Pages: 174-182

    • DOI

      10.1093/jjco/hyy173

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Squamous cell carcinoma arising from chronic osteomyelitis massively expanding into the medullary cavity: A case report.2019

    • Author(s)
      Kurihara T, Suehara Y, Akaike K, Hayashi T, Okubo T, Kim Y, Takagi T, Kaneko K, Yao T, Saito T.
    • Journal Title

      Human Pathology Case reports

      Volume: 16 Pages: 100288-100288

    • DOI

      10.1016/j.ehpc.2019.01.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fibrocartilaginous mesenchymoma of the tibia with predominant microcystic features: A case report and literature review2019

    • Author(s)
      Saito T, Motoi T, Suehara Y, Takagi T, Okubo T, Kurihara T, Hayashi T, Kudo T, Maruyama Y, Kaneko K, YaoT.
    • Journal Title

      Human Pathology Case reports

      Volume: 16 Pages: 100288-100288

    • DOI

      10.1016/j.ehpc.2019.01.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma.2018

    • Author(s)
      Ishii M, Suehara Y, Sano K, Kohsaka S, Hayashi T, Kazuno S, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T.
    • Journal Title

      Oncotarget

      Volume: 9(101) Issue: 101 Pages: 37509-37519

    • DOI

      10.18632/oncotarget.26493

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma.2018

    • Author(s)
      Akaike K, Suehara Y, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Kurihara T, Kim Y, Okubo T, Hayashi Y, Takamochi K, Takahashi F, Kaneko K, Ladanyi M, Saito T.
    • Journal Title

      Oncotarget

      Volume: 9(38) Issue: 38 Pages: 25206-25215

    • DOI

      10.18632/oncotarget.25392

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma.2018

    • Author(s)
      1.Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T.
    • Journal Title

      Hum Pathol

      Volume: 78 Pages: 79-88

    • DOI

      10.1016/j.humpath.2018.04.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KCTD12 is negatively regulated by Kit in gastrointestinal stromal tumors.2018

    • Author(s)
      Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M1, Kim Y, Tanabe Y, Takagi T, Hayashi T, Mogushi K, Kaneko K, Yao T, Saito T.
    • Journal Title

      Oncotarget

      Volume: 9(43) Issue: 43 Pages: 27016-27026

    • DOI

      10.18632/oncotarget.25469

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma.2018

    • Author(s)
      Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T.
    • Journal Title

      Oncotarget

      Volume: 9(18) Issue: 18 Pages: 14428-14443

    • DOI

      10.18632/oncotarget.24467

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-small cell lung carcinoma with diffuse co-expression of thyroid transcription factor-1 and ΔNp63/p402018

    • Author(s)
      Hayashi Takuo、Takamochi Kazuya、Yanai Yuka、Mitani Keiko、Tomita Hisashi、Mogushi Kaoru、Suehara Yoshiyuki、Takahashi Fumiyuki、Suzuki Kenji、Saito Tsuyoshi、Yao Takashi
    • Journal Title

      Human Pathology

      Volume: S0046-8177 Pages: 30037-6

    • DOI

      10.1016/j.humpath.2018.01.023

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion2018

    • Author(s)
      Kohsaka Shinji、Saito Tsuyoshi、Akaike Keisuke、Suehara Yoshiyuki、Hayashi Takuo、Takagi Tatsuya、Kaneko Kazuo、Ueno Toshihide、Kojima Shinya、Kohashi Ken-ichi、Mano Hiroyuki、Oda Yoshinao、Yao Takashi
    • Journal Title

      Human Pathology

      Volume: 72 Pages: 167-173

    • DOI

      10.1016/j.humpath.2017.08.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer2017

    • Author(s)
      Kohsaka Shinji、Nagano Masaaki、Ueno Toshihide、Suehara Yoshiyuki、Hayashi Takuo、Shimada Naoko、Takahashi Kazuhisa、Suzuki Kenji、Takamochi Kazuya、Takahashi Fumiyuki、Mano Hiroyuki
    • Journal Title

      Science Translational Medicine

      Volume: 9 Issue: 416 Pages: 6566-6566

    • DOI

      10.1126/scitranslmed.aan6566

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel2017

    • Author(s)
      Takamochi Kazuya、Takahashi Fumiyuki、Suehara Yoshiyuki、Sato Eiichi、Kohsaka Shinji、Hayashi Takuo、Kitano Shigehisa、Uneno Toshihide、Kojima Shinya、Takeuchi Kengo、Mano Hiroyuki、Suzuki Kenji
    • Journal Title

      Lung cancer

      Volume: 110 Pages: 26-31

    • DOI

      10.1016/j.lungcan.2017.05.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma2017

    • Author(s)
      Mukaihara K, Tanabe Y, Kubota D, Akaike K, Hayashi T, Mogushi K, Hosoya M, Sato S,Kobayashi E, Okubo T, Kohsaka S, Saito T, Kaneko K, Suehara Y.
    • Journal Title

      PLoS One

      Volume: 12(9) Issue: 9 Pages: 0185321-0185321

    • DOI

      10.1371/journal.pone.0185321

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arterial Thoracic Outlet Syndrome (aTOS) and Cerebellar Infarction Following a Stress Fracture of the First Rib and Extensive Callus2017

    • Author(s)
      7.Suehara Y, Imashimizu K, Miyamoto N, Uehara H, Tanabe Y, Hattori N, Suzuki K, Saito T, Kaneko K.
    • Journal Title

      J Bone Joint Surg. Case Connector

      Volume: 3 Issue: 3 Pages: e64-e64

    • DOI

      10.2106/jbjs.cc.17.00001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients.2016

    • Author(s)
      Saito T, Akaike K, Kurisaki A, Ishii M, Mukaihara K, Suehara Y, Takagi T, Kaneko K,
    • Journal Title

      Molecular and Clinical Oncology.

      Volume: 4(1) Issue: 1 Pages: 61-64

    • DOI

      10.3892/mco.2015.674

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab.2016

    • Author(s)
      Mukaihara K, Suehara Y, Kohsaka S, Akaike K, Tanabe Y, Kubota D, Ishii M, Fujimura T, Kazuno S, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: e0148401-e0148401

    • DOI

      10.1371/journal.pone.0148401

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expression of F-actin-capping protein subunit beta is associated with cell growth and motility in epithelioid sarcoma.2016

    • Author(s)
      Mukaihara K, Suehara Y*, Kohsaka S, Kubota D, Toda-Ishii M, Akaike K, Fujimura T, Kobayashi E, Yao T, Ladanyi, M, Kaneko K, Saito T.
    • Journal Title

      BMC cancer.

      Volume: 16(1) Issue: 1 Pages: 206-206

    • DOI

      10.1186/s12885-016-2235-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Outpatient-based Survey on the Recognition of Locomotive Syndrome in Japan: The Results of three Years of Surveys.2016

    • Author(s)
      Tanabe Y, Suehara Y, Okubo T, Kim Y, Ishii M,Kawasaki T, Matsuoka K, Akaike K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K.
    • Journal Title

      British Journal of Medicine & Medical Research.

      Volume: 15(9) Issue: 9 Pages: 1-9

    • DOI

      10.9734/bjmmr/2016/26127

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paget's sarcoma with sarcoma-specific TP53 mutation arising from a Japanese patient. International journal of clinical and experimental pathology.2016

    • Author(s)
      Akaike K, Toda-Ishii M, Suehara Y, Takagi T, Kaneko K,Yao T, Saito T.
    • Journal Title

      International journal of clinical and experimental pathology.

      Volume: 9(3) Pages: 3978-3986

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Large skin ulcer due to a subcutaneous orthopedic implant after bevacizumab therapy:2016

    • Author(s)
      Suehara Y*, Osawa H, Kubota D, Kato S, Akaike K, Tanabe Y, Saito T, Kaneko K.
    • Journal Title

      J Bone Joint Surg

      Volume: 6 (3) Issue: 3 Pages: e70-e70

    • DOI

      10.2106/jbjs.cc.15.00281

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors2016

    • Author(s)
      Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota K , Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T.
    • Journal Title

      Modern Pathology.

      Volume: 29 Issue: 11 Pages: 1424-1432

    • DOI

      10.1038/modpathol.2016.138

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reduced argininosuccinate synthetase expression in refractory sarcomas.2016

    • Author(s)
      Kim Y, Kobayashi E, Kubota D, Suehara Y, Mukaihara K, Akaike K, Ito A, Kaneko K, Chuman H, Kawai A, Kitano S.
    • Journal Title

      Oncotarget.

      Volume: 7(43) Issue: 43 Pages: 70832-70844

    • DOI

      10.18632/oncotarget.12225

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case report of using nivolumab for a malignant melanoma patient with rheumatoid arthritis2016

    • Author(s)
      Kageyama S, Yamaguchi S, Ito S, Suehara Y, Saito T, Akaike K, Miura K, Kato S.
    • Journal Title

      Int Canc Conf J.

      Volume: 5(4) Issue: 4 Pages: 192-196

    • DOI

      10.1007/s13691-016-0256-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A comparative study of 2 screening tools for locomotive syndrome (the “Loco-check” and the “GLFS-25”): An orthopedic outpatient-based survey.2016

    • Author(s)
      Kim Y, Suehara Y, Ishii M, Kawasaki T, Matsuoka K, Okubo T, Okubo N, Tanabe Y, Akaike K, Mukaihara K, Kubota D, Maruyama Y, Saito T, Kaneko K.
    • Journal Title

      British Journal of Medicine & Medical Research

      Volume: 17(5) Issue: 5 Pages: 1-13

    • DOI

      10.9734/bjmmr/2016/28194

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of secondary chondrosarcoma with TP53 mutation arising from fibrous dysplasia.2016

    • Author(s)
      Tomomasa R, Akaike K, Asahina M, Toda-Ishii M, Yashiro D, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.
    • Journal Title

      International journal of clinical and experimental pathology

      Volume: 9(7) Pages: 7230-7236

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A case of epithelioid hemangioma of the right third rib in a 55-year-old man.2016

    • Author(s)
      Saito T, Akaike K, Tomomasa R, Suehara Y, Takagi T, Kaneko K, Yao T.
    • Journal Title

      International journal of clinical and experimental pathology.

      Volume: 9(9) Pages: 9681-9686

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Recognition of Locomotive Syndrome in 2014: A Cross-sectional Study in the Orthopeadic Outpatients in Tokyo.2015

    • Author(s)
      Ishii M, Kim Y, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Kubota D, Okubo T, Saito T, Takagi T, Kaneko K.
    • Journal Title

      British Journal of Medicine & Medical Research

      Volume: 6(6) Issue: 6 Pages: 606-616

    • DOI

      10.9734/bjmmr/2015/14207

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Spindle cell lipoma of the wrist, occurring in a distinctly rare location: a case report with review of literature.2015

    • Author(s)
      Akaike K, Suehara Y, Takagi T, Kaneko K, Yamashita A, Yao T, Saito T.
    • Journal Title

      International journal of clinical and experimental pathology.

      Volume: 8 Pages: 3299-3303

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sarcomatous transformation of EGFR and TP53 mutation-positive metastatic adenocarcinoma of the lungs, masquerading as a primary pleomorphic sarcoma of the proximal femur.2015

    • Author(s)
      Toda-Ishii M, Akaike K, Kurisaki-Arakawa A, Arakawa A, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.
    • Journal Title

      International journal of clinical and experimental pathology.

      Volume: 8 Pages: 3270-3278

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases.2015

    • Author(s)
      Takagi T, Katagiri H, Kim Y, Suehara Y, Kubota D, Akaike K, Ishii M, Mukaihara K, Okubo T, Murata H, Takahashi M, Kaneko K, Saito T.
    • Journal Title

      PLoS ONE.

      Volume: 10 Issue: 6 Pages: e0129428-e0129428

    • DOI

      10.1371/journal.pone.0129428

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TERT promoter mutations are a rare event in gastrointestinal stromal tumors2015

    • Author(s)
      Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T.
    • Journal Title

      SpringerPlus

      Volume: 4 Issue: 1 Pages: 836-836

    • DOI

      10.1186/s40064-015-1606-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct clinicopathologic features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential.2014

    • Author(s)
      Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, Kaneko K, Yao T, Saito T.
    • Journal Title

      Hum Pathol.

      Volume: 46(3) Issue: 3 Pages: 347-356

    • DOI

      10.1016/j.humpath.2014.11.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Clinicopathological characteristics of lung adenocarcinoma with EGFR compound mutations.2019

    • Author(s)
      Hayashi T, Kohsaka S, Takamochi K, Takahashi F, Suehara Y, SaitoT, Suzuki K, Mano H, Yao T.
    • Organizer
      USCAP, the 2019 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic fluctuations in adriamycin-resistant osteosarcomas using metabolomic approaches2019

    • Author(s)
      Sasa K, Suehara Y, Akaike K, Hayashi T, Taka H, Youngji K, Okubo T, Kaneko K, Saito T.
    • Organizer
      the 65th Annual Meeting of the Orthopaedic Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IRE1α-XBP1 Inhibitor exerts antiyumor activity in osteosarcoma.2019

    • Author(s)
      Kurihara T, Suehara Y, Hayashi T, Akaike K, Okubo T, Kim Y, Kaneko K, Saito T.
    • Organizer
      the 65th Annual Meeting of the Orthopaedic Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive mRNA-based screen for tyrosine kinase fusions and a de novo alternative transcription initiation site in soft tissue sarcomas.2018

    • Author(s)
      Suehara Y, Kohsaka S, Kurisaki A, Akaike K, Hayashi T, Mogushi K, Okubo T, Kim Y, Sato S, Kobayashi E, Kaneko K, Mano H, Saito T.
    • Organizer
      European Society For Medical Oncology ASIA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IRE1α-XBP1 Inhibitor exerts antiyumor activity in osteosarcoma.2018

    • Author(s)
      Kurihara T, Suehara Y, Hayashi T, Akaike K, Okubo T, Kim Y, Kaneko K, Saito T.
    • Organizer
      Connective Tissue Oncology Society, 23th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expanded access of larotrectenib to manage pediatric TRK fusion sarcomas.2018

    • Author(s)
      Suehara Y, Trahair T, Kirby M, Saito S, Capra M, Ghosh T, Henry D, Ku NC, Cox MC, Kato S, Ziegler DS.
    • Organizer
      50th Congress of International Society of Paediatric Oncology,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical genomic sequencing of 72 pediatric and adult osteosarcomas reveals distinct molecular subsets with potentially targetable alterations.2018

    • Author(s)
      Alex D, Suehara Y, Bowman A, Middha S, Zehir A, Wang L, Jour G, Nafa K, Meyers P, Healey J, Hameed M, Ladanyi M.
    • Organizer
      USCAP, the 2018 Annual Meeting,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-tumor activity of tyrosine kinase inhibitors and gene expression profiles in alveolar soft part sarcoma.2018

    • Author(s)
      Suehara Y, Tanabe Y, Mukaihara K, Kurihara K, Akaike K, Hayashi T, Mogushi K, Kaneko K, Saito T.
    • Organizer
      the 64th Annual Meeting of the Orthopaedic Research Society 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proteomic approaches reveal that inhibition of the IRE1/XBP1 pathway reduces tumor growth in Ewing's sarcoma.2017

    • Author(s)
      Tanabe Y, Suehara Y, Kohsaka S, Mukaihara K, Kubota D, Akaike K, Ishii M, Kazuno S, Mineki R, Kaneko K, Ladanyi M, Saito T
    • Organizer
      the 63th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immune monitoring in patients with bone and soft tissue sarcoma.2017

    • Author(s)
      Kim Y, Kobayashi E, Kubota D, Suehara Y, Kawai A, Chuman H, Kaneko K, Ito A, Kitano S.
    • Organizer
      Connective Tissue Oncology Society, 22th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Practical screening system of oncogenic driver fusions in lung adenocarcinoma, using the NanoString nCounter.2017

    • Author(s)
      Takamochi K, Suehara Y, Takahashi F, Mogushi K, Kohsaka S, Mano H, Takeuchi K, Saito T, Hayashi T, Takahashi K, Suzuki S.
    • Organizer
      ESMO MAP
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-tumor activity of tyrosine kinase inhibitors in alveolar soft part sarcoma.2017

    • Author(s)
      Suehara Y, Tanabe Y, Akaike K, Mogushi K, Hayashi T, Kurihara T, Kaneko K, Saito T
    • Organizer
      European Society For Medical Oncology ASIA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A complete responder to pazopanib in high-grade soft tissue sarcomas.2017

    • Author(s)
      Suehara Y, Kohsaka S, Yamaguchi S, Akaike K, Hayashi T, Tanabe Y, Ueno T, Kojima S, Takeda I, Hayashi R, Saito T, Mano H, Kato S.
    • Organizer
      Connective Tissue Oncology Society, 22th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diagnostic strategy for skeletal metastasis of unknown primary origin at the initial visit/ Up-to-date treatment of skeletal metastasis2017

    • Author(s)
      Kim Y, Suehara Y, Kaneko K.
    • Organizer
      27th Korean-Japanese Combined Orthopedic Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Large skin ulcer due to a subcutaneous orthopedic implant after bevacizumab therapy: A case report2017

    • Author(s)
      Suehara Y, Kubota D, Kato S, Akaike K, Tanabe Y, Okubo T, Kim Y, Saito T, Kaneko K.
    • Organizer
      19th, International Symposium on Limb Salvage
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨軟部腫瘍のプレシジョンメディシンの可能性2017

    • Author(s)
      末原義之
    • Organizer
      第53回 Kyoto Orthopaedic Seminar
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 軟部肉腫Pazopanib著効例における分子病理学的探索2017

    • Author(s)
      末原義之、高阪真路、赤池慶祐、加藤俊介、林大久生、山口茂夫、田邊雄、窪田大介、高木辰哉、金子和夫、間野博行、齋藤剛
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 順天堂医院におけるがんクリニカルシークエンスMSK-IMPACTの試み2017

    • Author(s)
      末原 義之、林 大久生、山口茂夫、齋藤 剛、Marc Ladanyi、加藤 俊介
    • Organizer
      骨軟部腫瘍の基礎を語る会2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The Regulation of Malignant Transformation by PPP2R1A in Alveolar Rhabdomyosarcoma Based On A Proteomic Approach Corresponding To The PAX3/FOXO1 Fusion Gene.2016

    • Author(s)
      Akaike K, Suehara Y, Kohsaka S, Mukaihara K, Ishii M, Kubota D, Tanabe Y, Kazuno S, Mineki R, Fujimura T, Kaneko K, Ladanyi M, Saito T.
    • Organizer
      Connective Tissue Oncology Society, 21th Annual Meeting,
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microsatellite instability analysis using the Promega panel in lung adenocarcinoma.2016

    • Author(s)
      Takamochi K, Takahashi F, Suehara Y, Kitano S, Sato E, Kohsaka S, Hayashi T, Mano H, Suzuki K.
    • Organizer
      CHECT Annual Meeting
    • Place of Presentation
      Los Angeles, USA,
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protein expression profiling corresponding to giant cell tumors of bone treated with denosumab.2016

    • Author(s)
      Mukaihara K, Suehara Y, Akaike K, Tanabe Y, Kubota D, Ishii M, Kaneko K, Saito T.
    • Organizer
      The 11th Meeting of The Asia Pacific Musculoskeletal Tumour Society (APMSTS),
    • Place of Presentation
      Singapore
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Our efforts to bone and soft tissue tumors and bone metastases at Juntendo University.2016

    • Author(s)
      Kaneko K, Suehara Y, Yonji K, Takagi T.
    • Organizer
      The Korean Bone and Joint Tumor Society (KBJTS)
    • Place of Presentation
      Incheon, Korea.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinicopathological and functional analyses of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal cell tumors.2015

    • Author(s)
      Suehara Y, Ishii M, Akaike K, Mukaihara K, Kubota D, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
    • Organizer
      European Society For Medical Oncology - ASAIA
    • Place of Presentation
      Singapore
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] KCTD12 maybe negatively regulated by KIT in gastrointestinal stromal cell tumors.2015

    • Author(s)
      Akaike K, Suehara Y, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Ishii M, Mitomi H, Takahashi M, Takagi T, Kaneko K, Yao T, Saito T.
    • Organizer
      Connective Tissue Oncology Society, 20th Annual Meeting
    • Place of Presentation
      Salt Lake City, UT, USA
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases.2015

    • Author(s)
      Kim Y, Takagi T, Katagiri H, Suehara Y, Kubota D, Akaike D, Ishii M, Mukaihara K, Okubo T, Yazawa Y, Murata H, Takahashi M, Kaneko K, Saito T .
    • Organizer
      8th, International Symposium on Limb Salvage
    • Place of Presentation
      Orlando, Florida, US
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive analyses of Oncogenic Driver Fusions Using the NanoString nCounter in Lung Adenocarcinoma from Japanese Never- and Light-Smokers.2015

    • Author(s)
      Takamochi K, Suehara Y, Mogushi K, Kohsaka S, Mano H, Takeuchi K, Saito T, Suzuki K, Ladanyi M, Takahashi K, Takahashi F.
    • Organizer
      European Society For Medical Oncology
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinicopathological impacts of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors.2015

    • Author(s)
      Ishii M, Suehara Y, Akaike K, Mukaihara K, Kubota D, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
    • Organizer
      American Society of Clinical Oncology Annual Meeting,
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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