Development of novel therapeutic strategies for bone and soft tissue tumors

• Project/Area Number: 15H04964
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Juntendo University
• Principal Investigator: Suehara Yoshiyuki 順天堂大学, 医学部, 准教授 (70509405)
• Co-Investigator(Kenkyū-buntansha): 小林 英介 国立研究開発法人国立がん研究センター, 中央病院, 医長 (40365292) ; 北野 滋久 国立研究開発法人国立がん研究センター, 中央病院, 医員 (60402682) ; 齋藤 剛 順天堂大学, 医学部, 准教授 (80439736) ; 窪田 大介 順天堂大学, 医学部, 助教 (70638197)
• Research Collaborator: KOHSAKA Shinji
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 骨軟部腫瘍 / 骨軟部肉腫 / プロテオミクス / 融合遺伝子 / チロシンキナーゼ / 免疫応答 / がんクリニカルシークエンス / タンパク質発現解析 / 小胞体ストレス / 遺伝子変異 / 遺伝子変異解析 / チロシンキナーゼ阻害剤

Outline of Final Research Achievements

Our research projects conducted comprehensive researches harboring the proteomics, genomics, molecular pathogenesis and immune response of bone and soft tissue sarcomas, with an emphasis on the clinical translation of potential diagnostic markers and therapeutic targets.
In this study, we focused on some of t our main projects as follows: (1) Proteomic analyses of bone and soft tissue tumors, (2) The identification of novel tyrosine kinase mutations in lung cancer, (3) Immune response analyses of bone and soft tissue tumors. In this study, We successfully identified several novel therapeutic targets and biomarkers. We think that these identified gene and proteins may be useful for clinical application in the setting of bone and soft tissue tumors.

Academic Significance and Societal Importance of the Research Achievements

本研究は、難治性かつ「希少癌」である骨軟部腫瘍の生命予後の改善を目的として、治療成績向上の要となる腫瘍発生・悪性化・治療抵抗の原因因子を特定し、その結果に基づいた新規バイオマーカーや治療標的の開発を進めた。具体的には症例試料の確保、そして他癌で成功を収めている最新研究手法（(1)組織型特異的融合遺伝子のタンパク質発現解明、
(2)免疫応答解析による免疫担当細胞プロファイリング、(3) TK阻害剤などが奏効するTK遺伝子変異の探索）を取り入れて研究を推進することで新規治療法開発を行い、希少癌患者の生命予後改善を試みた。

Research Products

• [Int'l Joint Research] Memorial Sloan Kettering Cancer Center/Department of Pathology/Marc Ladanyi(米国)
• [Int'l Joint Research] メモリアルスローンケタリングがんセンター(米国)
• [Int'l Joint Research]
• [Int'l Joint Research] Memorial Sloan-Kettering Cancer Center(米国)
• [Journal Article] Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens (2019)
  • Author(s): Kohsaka Shinji、Tatsuno Kenji、Ueno Toshihide、et al.
  • Journal Title: Cancer Science Volume: 110 Issue: 4 Pages: 1464-1479
  • DOI: 10.1111/cas.13968
  • Peer Reviewed / Open Access
• [Journal Article] Multicenter experience with large panel next-generation sequencing in patients with advanced solid cancers in Japan. (2019)
  • Author(s): Kato S, Hayashi T, Suehara Y, Hamanoue H, Yamanaka S, Ichikawa Y, Higurashi T, Ohashi K, Yamaguchi S, Nozaki Y, Terao Y, Saito T.
  • Journal Title: Jpn J Clin Oncol Volume: 49(2) Issue: 2 Pages: 174-182
  • DOI: 10.1093/jjco/hyy173
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Squamous cell carcinoma arising from chronic osteomyelitis massively expanding into the medullary cavity: A case report. (2019)
  • Author(s): Kurihara T, Suehara Y, Akaike K, Hayashi T, Okubo T, Kim Y, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: Human Pathology Case reports Volume: 16 Pages: 100288-100288
  • DOI: 10.1016/j.ehpc.2019.01.008
  • Peer Reviewed / Open Access
• [Journal Article] Fibrocartilaginous mesenchymoma of the tibia with predominant microcystic features: A case report and literature review (2019)
  • Author(s): Saito T, Motoi T, Suehara Y, Takagi T, Okubo T, Kurihara T, Hayashi T, Kudo T, Maruyama Y, Kaneko K, YaoT.
  • Journal Title: Human Pathology Case reports Volume: 16 Pages: 100288-100288
  • DOI: 10.1016/j.ehpc.2019.01.007
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma. (2018)
  • Author(s): Ishii M, Suehara Y, Sano K, Kohsaka S, Hayashi T, Kazuno S, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T.
  • Journal Title: Oncotarget Volume: 9(101) Issue: 101 Pages: 37509-37519
  • DOI: 10.18632/oncotarget.26493
  • Peer Reviewed / Open Access
• [Journal Article] PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma. (2018)
  • Author(s): Akaike K, Suehara Y, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Kurihara T, Kim Y, Okubo T, Hayashi Y, Takamochi K, Takahashi F, Kaneko K, Ladanyi M, Saito T.
  • Journal Title: Oncotarget Volume: 9(38) Issue: 38 Pages: 25206-25215
  • DOI: 10.18632/oncotarget.25392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma. (2018)
  • Author(s): 1.Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T.
  • Journal Title: Hum Pathol Volume: 78 Pages: 79-88
  • DOI: 10.1016/j.humpath.2018.04.022
  • Peer Reviewed / Open Access
• [Journal Article] KCTD12 is negatively regulated by Kit in gastrointestinal stromal tumors. (2018)
  • Author(s): Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M1, Kim Y, Tanabe Y, Takagi T, Hayashi T, Mogushi K, Kaneko K, Yao T, Saito T.
  • Journal Title: Oncotarget Volume: 9(43) Issue: 43 Pages: 27016-27026
  • DOI: 10.18632/oncotarget.25469
  • Peer Reviewed / Open Access
• [Journal Article] IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma. (2018)
  • Author(s): Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T.
  • Journal Title: Oncotarget Volume: 9(18) Issue: 18 Pages: 14428-14443
  • DOI: 10.18632/oncotarget.24467
  • Peer Reviewed / Open Access
• [Journal Article] Non-small cell lung carcinoma with diffuse co-expression of thyroid transcription factor-1 and ΔNp63/p40 (2018)
  • Author(s): Hayashi Takuo、Takamochi Kazuya、Yanai Yuka、Mitani Keiko、Tomita Hisashi、Mogushi Kaoru、Suehara Yoshiyuki、Takahashi Fumiyuki、Suzuki Kenji、Saito Tsuyoshi、Yao Takashi
  • Journal Title: Human Pathology Volume: S0046-8177 Pages: 30037-6
  • DOI: 10.1016/j.humpath.2018.01.023
  • Peer Reviewed / Open Access
• [Journal Article] Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion (2018)
  • Author(s): Kohsaka Shinji、Saito Tsuyoshi、Akaike Keisuke、Suehara Yoshiyuki、Hayashi Takuo、Takagi Tatsuya、Kaneko Kazuo、Ueno Toshihide、Kojima Shinya、Kohashi Ken-ichi、Mano Hiroyuki、Oda Yoshinao、Yao Takashi
  • Journal Title: Human Pathology Volume: 72 Pages: 167-173
  • DOI: 10.1016/j.humpath.2017.08.017
  • Peer Reviewed / Open Access
• [Journal Article] A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer (2017)
  • Author(s): Kohsaka Shinji、Nagano Masaaki、Ueno Toshihide、Suehara Yoshiyuki、Hayashi Takuo、Shimada Naoko、Takahashi Kazuhisa、Suzuki Kenji、Takamochi Kazuya、Takahashi Fumiyuki、Mano Hiroyuki
  • Journal Title: Science Translational Medicine Volume: 9 Issue: 416 Pages: 6566-6566
  • DOI: 10.1126/scitranslmed.aan6566
  • Peer Reviewed / Open Access
• [Journal Article] DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel (2017)
  • Author(s): Takamochi Kazuya、Takahashi Fumiyuki、Suehara Yoshiyuki、Sato Eiichi、Kohsaka Shinji、Hayashi Takuo、Kitano Shigehisa、Uneno Toshihide、Kojima Shinya、Takeuchi Kengo、Mano Hiroyuki、Suzuki Kenji
  • Journal Title: Lung cancer Volume: 110 Pages: 26-31
  • DOI: 10.1016/j.lungcan.2017.05.016
  • Peer Reviewed / Open Access
• [Journal Article] Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma (2017)
  • Author(s): Mukaihara K, Tanabe Y, Kubota D, Akaike K, Hayashi T, Mogushi K, Hosoya M, Sato S,Kobayashi E, Okubo T, Kohsaka S, Saito T, Kaneko K, Suehara Y.
  • Journal Title: PLoS One Volume: 12(9) Issue: 9 Pages: 0185321-0185321
  • DOI: 10.1371/journal.pone.0185321
  • Peer Reviewed / Open Access
• [Journal Article] Arterial Thoracic Outlet Syndrome (aTOS) and Cerebellar Infarction Following a Stress Fracture of the First Rib and Extensive Callus (2017)
  • Author(s): 7.Suehara Y, Imashimizu K, Miyamoto N, Uehara H, Tanabe Y, Hattori N, Suzuki K, Saito T, Kaneko K.
  • Journal Title: J Bone Joint Surg. Case Connector Volume: 3 Issue: 3 Pages: e64-e64
  • DOI: 10.2106/jbjs.cc.17.00001
  • Peer Reviewed
• [Journal Article] TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients. (2016)
  • Author(s): Saito T, Akaike K, Kurisaki A, Ishii M, Mukaihara K, Suehara Y, Takagi T, Kaneko K,
  • Journal Title: Molecular and Clinical Oncology. Volume: 4(1) Issue: 1 Pages: 61-64
  • DOI: 10.3892/mco.2015.674
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab. (2016)
  • Author(s): Mukaihara K, Suehara Y, Kohsaka S, Akaike K, Tanabe Y, Kubota D, Ishii M, Fujimura T, Kazuno S, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
  • Journal Title: PLoS One Volume: 10 Issue: 2 Pages: e0148401-e0148401
  • DOI: 10.1371/journal.pone.0148401
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Expression of F-actin-capping protein subunit beta is associated with cell growth and motility in epithelioid sarcoma. (2016)
  • Author(s): Mukaihara K, Suehara Y*, Kohsaka S, Kubota D, Toda-Ishii M, Akaike K, Fujimura T, Kobayashi E, Yao T, Ladanyi, M, Kaneko K, Saito T.
  • Journal Title: BMC cancer. Volume: 16(1) Issue: 1 Pages: 206-206
  • DOI: 10.1186/s12885-016-2235-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An Outpatient-based Survey on the Recognition of Locomotive Syndrome in Japan: The Results of three Years of Surveys. (2016)
  • Author(s): Tanabe Y, Suehara Y, Okubo T, Kim Y, Ishii M,Kawasaki T, Matsuoka K, Akaike K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K.
  • Journal Title: British Journal of Medicine & Medical Research. Volume: 15(9) Issue: 9 Pages: 1-9
  • DOI: 10.9734/bjmmr/2016/26127
  • Peer Reviewed / Open Access
• [Journal Article] Paget's sarcoma with sarcoma-specific TP53 mutation arising from a Japanese patient. International journal of clinical and experimental pathology. (2016)
  • Author(s): Akaike K, Toda-Ishii M, Suehara Y, Takagi T, Kaneko K,Yao T, Saito T.
  • Journal Title: International journal of clinical and experimental pathology. Volume: 9(3) Pages: 3978-3986
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Large skin ulcer due to a subcutaneous orthopedic implant after bevacizumab therapy: (2016)
  • Author(s): Suehara Y*, Osawa H, Kubota D, Kato S, Akaike K, Tanabe Y, Saito T, Kaneko K.
  • Journal Title: J Bone Joint Surg Volume: 6 (3) Issue: 3 Pages: e70-e70
  • DOI: 10.2106/jbjs.cc.15.00281
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors (2016)
  • Author(s): Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota K , Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: Modern Pathology. Volume: 29 Issue: 11 Pages: 1424-1432
  • DOI: 10.1038/modpathol.2016.138
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reduced argininosuccinate synthetase expression in refractory sarcomas. (2016)
  • Author(s): Kim Y, Kobayashi E, Kubota D, Suehara Y, Mukaihara K, Akaike K, Ito A, Kaneko K, Chuman H, Kawai A, Kitano S.
  • Journal Title: Oncotarget. Volume: 7(43) Issue: 43 Pages: 70832-70844
  • DOI: 10.18632/oncotarget.12225
  • Peer Reviewed / Open Access
• [Journal Article] A case report of using nivolumab for a malignant melanoma patient with rheumatoid arthritis (2016)
  • Author(s): Kageyama S, Yamaguchi S, Ito S, Suehara Y, Saito T, Akaike K, Miura K, Kato S.
  • Journal Title: Int Canc Conf J. Volume: 5(4) Issue: 4 Pages: 192-196
  • DOI: 10.1007/s13691-016-0256-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A comparative study of 2 screening tools for locomotive syndrome (the “Loco-check” and the “GLFS-25”): An orthopedic outpatient-based survey. (2016)
  • Author(s): Kim Y, Suehara Y, Ishii M, Kawasaki T, Matsuoka K, Okubo T, Okubo N, Tanabe Y, Akaike K, Mukaihara K, Kubota D, Maruyama Y, Saito T, Kaneko K.
  • Journal Title: British Journal of Medicine & Medical Research Volume: 17(5) Issue: 5 Pages: 1-13
  • DOI: 10.9734/bjmmr/2016/28194
  • Peer Reviewed / Open Access
• [Journal Article] A case of secondary chondrosarcoma with TP53 mutation arising from fibrous dysplasia. (2016)
  • Author(s): Tomomasa R, Akaike K, Asahina M, Toda-Ishii M, Yashiro D, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: International journal of clinical and experimental pathology Volume: 9(7) Pages: 7230-7236
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A case of epithelioid hemangioma of the right third rib in a 55-year-old man. (2016)
  • Author(s): Saito T, Akaike K, Tomomasa R, Suehara Y, Takagi T, Kaneko K, Yao T.
  • Journal Title: International journal of clinical and experimental pathology. Volume: 9(9) Pages: 9681-9686
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Recognition of Locomotive Syndrome in 2014: A Cross-sectional Study in the Orthopeadic Outpatients in Tokyo. (2015)
  • Author(s): Ishii M, Kim Y, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Kubota D, Okubo T, Saito T, Takagi T, Kaneko K.
  • Journal Title: British Journal of Medicine & Medical Research Volume: 6(6) Issue: 6 Pages: 606-616
  • DOI: 10.9734/bjmmr/2015/14207
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Spindle cell lipoma of the wrist, occurring in a distinctly rare location: a case report with review of literature. (2015)
  • Author(s): Akaike K, Suehara Y, Takagi T, Kaneko K, Yamashita A, Yao T, Saito T.
  • Journal Title: International journal of clinical and experimental pathology. Volume: 8 Pages: 3299-3303
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sarcomatous transformation of EGFR and TP53 mutation-positive metastatic adenocarcinoma of the lungs, masquerading as a primary pleomorphic sarcoma of the proximal femur. (2015)
  • Author(s): Toda-Ishii M, Akaike K, Kurisaki-Arakawa A, Arakawa A, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: International journal of clinical and experimental pathology. Volume: 8 Pages: 3270-3278
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases. (2015)
  • Author(s): Takagi T, Katagiri H, Kim Y, Suehara Y, Kubota D, Akaike K, Ishii M, Mukaihara K, Okubo T, Murata H, Takahashi M, Kaneko K, Saito T.
  • Journal Title: PLoS ONE. Volume: 10 Issue: 6 Pages: e0129428-e0129428
  • DOI: 10.1371/journal.pone.0129428
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] TERT promoter mutations are a rare event in gastrointestinal stromal tumors (2015)
  • Author(s): Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: SpringerPlus Volume: 4 Issue: 1 Pages: 836-836
  • DOI: 10.1186/s40064-015-1606-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distinct clinicopathologic features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential. (2014)
  • Author(s): Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, Kaneko K, Yao T, Saito T.
  • Journal Title: Hum Pathol. Volume: 46(3) Issue: 3 Pages: 347-356
  • DOI: 10.1016/j.humpath.2014.11.018
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Clinicopathological characteristics of lung adenocarcinoma with EGFR compound mutations. (2019)
  • Author(s): Hayashi T, Kohsaka S, Takamochi K, Takahashi F, Suehara Y, SaitoT, Suzuki K, Mano H, Yao T.
  • Organizer: USCAP, the 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Metabolic fluctuations in adriamycin-resistant osteosarcomas using metabolomic approaches (2019)
  • Author(s): Sasa K, Suehara Y, Akaike K, Hayashi T, Taka H, Youngji K, Okubo T, Kaneko K, Saito T.
  • Organizer: the 65th Annual Meeting of the Orthopaedic Research Society
  • Int'l Joint Research
• [Presentation] IRE1α-XBP1 Inhibitor exerts antiyumor activity in osteosarcoma. (2019)
  • Author(s): Kurihara T, Suehara Y, Hayashi T, Akaike K, Okubo T, Kim Y, Kaneko K, Saito T.
  • Organizer: the 65th Annual Meeting of the Orthopaedic Research Society
  • Int'l Joint Research
• [Presentation] Comprehensive mRNA-based screen for tyrosine kinase fusions and a de novo alternative transcription initiation site in soft tissue sarcomas. (2018)
  • Author(s): Suehara Y, Kohsaka S, Kurisaki A, Akaike K, Hayashi T, Mogushi K, Okubo T, Kim Y, Sato S, Kobayashi E, Kaneko K, Mano H, Saito T.
  • Organizer: European Society For Medical Oncology ASIA
  • Int'l Joint Research
• [Presentation] IRE1α-XBP1 Inhibitor exerts antiyumor activity in osteosarcoma. (2018)
  • Author(s): Kurihara T, Suehara Y, Hayashi T, Akaike K, Okubo T, Kim Y, Kaneko K, Saito T.
  • Organizer: Connective Tissue Oncology Society, 23th Annual Meeting
  • Int'l Joint Research
• [Presentation] Expanded access of larotrectenib to manage pediatric TRK fusion sarcomas. (2018)
  • Author(s): Suehara Y, Trahair T, Kirby M, Saito S, Capra M, Ghosh T, Henry D, Ku NC, Cox MC, Kato S, Ziegler DS.
  • Organizer: 50th Congress of International Society of Paediatric Oncology,
  • Int'l Joint Research
• [Presentation] Clinical genomic sequencing of 72 pediatric and adult osteosarcomas reveals distinct molecular subsets with potentially targetable alterations. (2018)
  • Author(s): Alex D, Suehara Y, Bowman A, Middha S, Zehir A, Wang L, Jour G, Nafa K, Meyers P, Healey J, Hameed M, Ladanyi M.
  • Organizer: USCAP, the 2018 Annual Meeting,
  • Int'l Joint Research
• [Presentation] Anti-tumor activity of tyrosine kinase inhibitors and gene expression profiles in alveolar soft part sarcoma. (2018)
  • Author(s): Suehara Y, Tanabe Y, Mukaihara K, Kurihara K, Akaike K, Hayashi T, Mogushi K, Kaneko K, Saito T.
  • Organizer: the 64th Annual Meeting of the Orthopaedic Research Society 2018
  • Int'l Joint Research
• [Presentation] Proteomic approaches reveal that inhibition of the IRE1/XBP1 pathway reduces tumor growth in Ewing's sarcoma. (2017)
  • Author(s): Tanabe Y, Suehara Y, Kohsaka S, Mukaihara K, Kubota D, Akaike K, Ishii M, Kazuno S, Mineki R, Kaneko K, Ladanyi M, Saito T
  • Organizer: the 63th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: San Diego, USA
  • Year and Date: 2017-03-19
  • Int'l Joint Research
• [Presentation] Immune monitoring in patients with bone and soft tissue sarcoma. (2017)
  • Author(s): Kim Y, Kobayashi E, Kubota D, Suehara Y, Kawai A, Chuman H, Kaneko K, Ito A, Kitano S.
  • Organizer: Connective Tissue Oncology Society, 22th Annual Meeting
  • Int'l Joint Research
• [Presentation] Practical screening system of oncogenic driver fusions in lung adenocarcinoma, using the NanoString nCounter. (2017)
  • Author(s): Takamochi K, Suehara Y, Takahashi F, Mogushi K, Kohsaka S, Mano H, Takeuchi K, Saito T, Hayashi T, Takahashi K, Suzuki S.
  • Organizer: ESMO MAP
  • Int'l Joint Research
• [Presentation] Anti-tumor activity of tyrosine kinase inhibitors in alveolar soft part sarcoma. (2017)
  • Author(s): Suehara Y, Tanabe Y, Akaike K, Mogushi K, Hayashi T, Kurihara T, Kaneko K, Saito T
  • Organizer: European Society For Medical Oncology ASIA
  • Int'l Joint Research
• [Presentation] A complete responder to pazopanib in high-grade soft tissue sarcomas. (2017)
  • Author(s): Suehara Y, Kohsaka S, Yamaguchi S, Akaike K, Hayashi T, Tanabe Y, Ueno T, Kojima S, Takeda I, Hayashi R, Saito T, Mano H, Kato S.
  • Organizer: Connective Tissue Oncology Society, 22th Annual Meeting
  • Int'l Joint Research
• [Presentation] Diagnostic strategy for skeletal metastasis of unknown primary origin at the initial visit/ Up-to-date treatment of skeletal metastasis (2017)
  • Author(s): Kim Y, Suehara Y, Kaneko K.
  • Organizer: 27th Korean-Japanese Combined Orthopedic Symposium
  • Int'l Joint Research / Invited
• [Presentation] Large skin ulcer due to a subcutaneous orthopedic implant after bevacizumab therapy: A case report (2017)
  • Author(s): Suehara Y, Kubota D, Kato S, Akaike K, Tanabe Y, Okubo T, Kim Y, Saito T, Kaneko K.
  • Organizer: 19th, International Symposium on Limb Salvage
  • Int'l Joint Research
• [Presentation] 骨軟部腫瘍のプレシジョンメディシンの可能性 (2017)
  • Author(s): 末原義之
  • Organizer: 第53回 Kyoto Orthopaedic Seminar
  • Invited
• [Presentation] 軟部肉腫Pazopanib著効例における分子病理学的探索 (2017)
  • Author(s): 末原義之、高阪真路、赤池慶祐、加藤俊介、林大久生、山口茂夫、田邊雄、窪田大介、高木辰哉、金子和夫、間野博行、齋藤剛
  • Organizer: 第32回日本整形外科学会基礎学術集会
  • Invited
• [Presentation] 順天堂医院におけるがんクリニカルシークエンスMSK-IMPACTの試み (2017)
  • Author(s): 末原 義之、林 大久生、山口茂夫、齋藤 剛、Marc Ladanyi、加藤 俊介
  • Organizer: 骨軟部腫瘍の基礎を語る会2017
  • Invited
• [Presentation] The Regulation of Malignant Transformation by PPP2R1A in Alveolar Rhabdomyosarcoma Based On A Proteomic Approach Corresponding To The PAX3/FOXO1 Fusion Gene. (2016)
  • Author(s): Akaike K, Suehara Y, Kohsaka S, Mukaihara K, Ishii M, Kubota D, Tanabe Y, Kazuno S, Mineki R, Fujimura T, Kaneko K, Ladanyi M, Saito T.
  • Organizer: Connective Tissue Oncology Society, 21th Annual Meeting,
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] Microsatellite instability analysis using the Promega panel in lung adenocarcinoma. (2016)
  • Author(s): Takamochi K, Takahashi F, Suehara Y, Kitano S, Sato E, Kohsaka S, Hayashi T, Mano H, Suzuki K.
  • Organizer: CHECT Annual Meeting
  • Place of Presentation: Los Angeles, USA,
  • Year and Date: 2016-10-22
  • Int'l Joint Research
• [Presentation] Protein expression profiling corresponding to giant cell tumors of bone treated with denosumab. (2016)
  • Author(s): Mukaihara K, Suehara Y, Akaike K, Tanabe Y, Kubota D, Ishii M, Kaneko K, Saito T.
  • Organizer: The 11th Meeting of The Asia Pacific Musculoskeletal Tumour Society (APMSTS),
  • Place of Presentation: Singapore
  • Year and Date: 2016-04-21
  • Int'l Joint Research
• [Presentation] Our efforts to bone and soft tissue tumors and bone metastases at Juntendo University. (2016)
  • Author(s): Kaneko K, Suehara Y, Yonji K, Takagi T.
  • Organizer: The Korean Bone and Joint Tumor Society (KBJTS)
  • Place of Presentation: Incheon, Korea.
  • Int'l Joint Research / Invited
• [Presentation] Clinicopathological and functional analyses of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal cell tumors. (2015)
  • Author(s): Suehara Y, Ishii M, Akaike K, Mukaihara K, Kubota D, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
  • Organizer: European Society For Medical Oncology - ASAIA
  • Place of Presentation: Singapore
  • Year and Date: 2015-12-18
  • Int'l Joint Research
• [Presentation] KCTD12 maybe negatively regulated by KIT in gastrointestinal stromal cell tumors. (2015)
  • Author(s): Akaike K, Suehara Y, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Ishii M, Mitomi H, Takahashi M, Takagi T, Kaneko K, Yao T, Saito T.
  • Organizer: Connective Tissue Oncology Society, 20th Annual Meeting
  • Place of Presentation: Salt Lake City, UT, USA
  • Year and Date: 2015-11-04
  • Int'l Joint Research
• [Presentation] Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases. (2015)
  • Author(s): Kim Y, Takagi T, Katagiri H, Suehara Y, Kubota D, Akaike D, Ishii M, Mukaihara K, Okubo T, Yazawa Y, Murata H, Takahashi M, Kaneko K, Saito T .
  • Organizer: 8th, International Symposium on Limb Salvage
  • Place of Presentation: Orlando, Florida, US
  • Year and Date: 2015-10-06
  • Int'l Joint Research
• [Presentation] Comprehensive analyses of Oncogenic Driver Fusions Using the NanoString nCounter in Lung Adenocarcinoma from Japanese Never- and Light-Smokers. (2015)
  • Author(s): Takamochi K, Suehara Y, Mogushi K, Kohsaka S, Mano H, Takeuchi K, Saito T, Suzuki K, Ladanyi M, Takahashi K, Takahashi F.
  • Organizer: European Society For Medical Oncology
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] Clinicopathological impacts of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors. (2015)
  • Author(s): Ishii M, Suehara Y, Akaike K, Mukaihara K, Kubota D, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
  • Organizer: American Society of Clinical Oncology Annual Meeting,
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-05-29
  • Int'l Joint Research