| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Outline of Final Research Achievements |
We have found that massage-like mechanical interventions modulate immobilization-induced pro-inflammatory responses of macrophages in situ and alleviate muscle atrophy. Local cyclical compression (LCC) on mouse calves, which generates intramuscular pressure waves with amplitude of 50 mmHg, partially restores the thickness of calf muscle fibers, which is decreased by hindlimb immobilization using spiral wiring. LCC tempers the increases in the number of macrophage and the expressions of pro-inflammatory proteins in situ. The reversing effect of LCC on immobilization-induced thinning of muscle fibers is almost completely nullified when phagocytic macrophages are depleted. These results suggest that mechanical modulation of macrophage function is involved in physical inactivity-induced muscle atrophy and inflammation. Our findings may open a new path to develop a novel therapeutic or preventative strategy against disuse muscle atrophy, utilizing mechanical interventions.
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