| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
We developed a postoperative persistent pain model, and analyzed the variation of cytokines according to the time course. The expression patterns in KO mice with diminished pain related behavior were remarkably different from those of WT.
Changes in the brain activity evaluated using Manganese-Enhanced MRI(MEMRI) in the pain model showed no significant difference in the enhanced level at each region between naïve, acute and chronic stages. However, their patterns of co-enhanced level were significantly different from those before the surgery in both acute and chronic stages.
We evaluated the brain activity by MEMRI using animals that showed significant higher thresholds of mechanical stimulation after administration of analgesics. Brain activity patterns showed that buprenorphine-administered animals displayed resemble pattern of pre-surgery animals. We also confirmed dose dependent patterns when comparing to naïve, low-dose and high-dose gabapentin-administered animals.
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