| Project/Area Number |
15H04972
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小泉 修一 山梨大学, 大学院総合研究部, 教授 (10280752)
富永 真琴 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (90260041)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIYAMA Mitsuharu 山梨大学, 大学院総合研究部, 医学研究員 (20422694)
SAWADA Norifumi 山梨大学, 大学院総合研究部, 講師 (70402055)
KIRA Satoru 山梨大学, 大学院総合研究部, 助教 (10530115)
IHARA Tatsuya 山梨大学, 大学院総合研究部, 助教 (90622407)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | Lower urinary tract / Clock genes / Mechanosensor / Metabolomics / Biomarker / nocturia / clock gene / noctrunal polyuria / metabolomics / 下部尿路機能障害 / 複雑系ネットワーク / 動的恒常性破綻 / 発症機序 / P2Y6受容体欠損マウス / 時計遺伝子異常 / 夜間頻尿 / ＴＲＰチャネル / 排尿機能学 / 下部尿路機能 / 動的恒常性 / 時計遺伝子 / 機械センサー |
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| Outline of Final Research Achievements |
We demonstrated that ClockD19/D19 mice showed the phenotype of NOC/NP. The ClockD19/D19 mouse may be used as an animal model of NOC and NP.The gene expression of mechanosensor, Cx26 and VNUT was maintained at a higher level in spite of the sleep phase.We demonstrated that the time-dependent gene expressions, including clock genes, mechano-sensors, and ARMM, were reproducible in UCs. These findings demonstrated that UCs have the potential to progress research into the circadian functions of the lower urinary tract regulated by clock genes.The expressions of Cxs and TRP channels on urothelial cells in voided urine could be related to LUTS. Male lower urinary tract symptoms may develop due to abnormalmetabolic processes in some pathways. Potential new treatments for lower urinary tract symptoms can be developed by identifying changes in the amino acid profiles.
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