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Clarification of the multistage carcinogenesis and basis of the innovative therapeutics for Renal Cell Carcinoma

Research Project

Project/Area Number 15H04975
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKumamoto University

Principal Investigator

Baba Masaya  熊本大学, 国際先端医学研究機構, 准教授 (10347304)

Co-Investigator(Kenkyū-buntansha) 江藤 正俊  九州大学, 大学病院, 教授 (90315078)
矢尾 正祐  横浜市立大学, 医学研究科, 教授 (00260787)
長嶋 洋治  東京女子医科大学, 医学部, 教授 (10217995)
古屋 充子  横浜市立大学, 医学部, 准教授 (10361445)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords腎細胞癌 / がん抑制遺伝子 / Birt-Hogg-Dube症候群 / 転座型腎細胞癌 / 発がん分子機構 / FLCN / 多段階発癌 / フォワードジェネティクス / マウスモデル / BHD症候群 / 転座腎細胞癌 / ドライバー遺伝子 / 腎がん / 転座腎がん
Outline of Final Research Achievements

In this study, we focused on two kinds of renal cell carcinoma (RCC), BHD associated RCC whose responsible gene is a tumor suppressor FLCN, and Xp11.2 translocation RCC (tRCC) that expresses chimeric TFE3 produced by Xp11.2 translocation. We utilized genetically engineered mice, human RCC tissues and cell lines to study molecular mechanisms for RCC development, identify driver gene mutations, and develop new diagnostic markers or therapeutics for RCC. We clarified that FLCN altered intracellular signaling through the regulation of cellular metabolism. We then demonstrated that chromatin remodeling genes were frequently mutated in BHD associated RCC. We also demonstrated that chimeric TFE3 proteins worked as oncogenic transcription factors by acquiring altered functions. Finally, we identified a diagnostic marker for tRCC and confirmed its efficacy using human tRCC samples.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (55 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (8 results) Journal Article (10 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 10 results,  Open Access: 9 results,  Acknowledgement Compliant: 4 results) Presentation (31 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results) Book (4 results) Remarks (2 results)

  • [Int'l Joint Research] National Cancer Institute(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] National University of Singapore(Singapore)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] National Cancer Institute(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] National University of Singapore(シンガポール)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 米国国立癌研究所(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] マギル大学(カナダ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] シンガポール国立大学(シンガポール)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Folliculin regulates osteoclastogenesis through metabolic regulation2018

    • Author(s)
      Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M ,Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, Suda T
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes2018

    • Author(s)
      Hasumi H., Furuya M, Tatsuno K, Yamamoto S, Baba M, Hasumi Yukiko, Isono Yasuhiro, Suzuki K, Jikuya R, Otake S, Muraoka K, Osaka K, Hayashi N, Makiyama K, Miyoshi Y, Kondo K, Nakaigawa N, Kawahara T, Izumi K, Teranishi J, Yumura Y, Uemura H, Nagashima Y, Metwalli A.R., Schmidt L.S., Aburatani H, Linehan W.M., Yao M.
    • Journal Title

      Human Molecular Genetics

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Splice-site mutation causing partial retention of intron in the FLCN gene in Birt- Hogg-Dube syndrome: a case report2018

    • Author(s)
      Furuya M, Kobayashi H, Baba M, Ito T, Tanaka R, Nakatani Y
    • Journal Title

      BMC Medical Genomics

      Volume: 42 Issue: 1 Pages: 42-42

    • DOI

      10.1186/s12920-018-0359-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Review of hereditary leiomyomatosis renal cell carcinoma with focus on clinical and pathobiological aspects of renal tumor2017

    • Author(s)
      Kuroda N, Ohe C, Kato I, Furuya M, Baba M, Nagashima Y, Nakatani Y, Murakami I, Zhou M, Michal M, He O, Amin MB
    • Journal Title

      Pol J Pathol

      Volume: 68 Issue: 4 Pages: 284-290

    • DOI

      10.5114/pjp.2017.73920

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt-Hogg-Dube syndrome2017

    • Author(s)
      Furuya M, Hasumi H, Baba M, Tanaka R, Iribe Y, Onishi T, Nagashima Y, Nakatani Y, Isono Y, Yao M.
    • Journal Title

      Laboratory Investigation

      Volume: 97 Issue: 3 Pages: 343-351

    • DOI

      10.1038/labinvest.2016.137

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.2017

    • Author(s)
      Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Lang M, Irie N, Esumi C, Merino MJ, Kawahara T, Isono Y, Makiyama K, Warner AC, Haines DC, Wei MH, Zbar B, Hagenau H, Feigenbaum L, Kondo K, Nakaigawa N, Yao M, Metwalli AR, Marston Linehan W, Schmidt LS
    • Journal Title

      Human Molecular Genetics

      Volume: 26 Pages: 354-366

    • DOI

      10.1093/hmg/ddw392

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genetic, epidemiologic and clinicopathologic studies of Japanese Asian patients with Birt-Hogg-Dube syndrome.2016

    • Author(s)
      Furuya M, Yao M, Tanaka R, Nagashima Y, Kuroda N, Hasumi H, Baba M, Matsushima J, Nomura F, Nakatani Y
    • Journal Title

      Clinical Genetics

      Volume: 90 Issue: 5 Pages: 403-412

    • DOI

      10.1111/cge.12807

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα2016

    • Author(s)
      Yan M, Audet-Walsh E, Manteghi S, Rosa Dufour C, Walker B, Baba M, St-Pierre J, Giguere V, Pause A.
    • Journal Title

      Genes & Development

      Volume: 30 Issue: 9 Pages: 1034-1046

    • DOI

      10.1101/gad.281410.116

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure2016

    • Author(s)
      Baba M, Toyama H, Sun L, Takubo K, Suh HC, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Nakagata N, Schmidt LS, Linehan WM, Suda T, Keller JR
    • Journal Title

      Stem Cells

      Volume: 34 Issue: 4 Pages: 1068-1082

    • DOI

      10.1002/stem.2293

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Birt-Hogg-Dubé syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome.2015

    • Author(s)
      Hasumi H, Baba M, Hasumi Y, Furuya M, Yao M.
    • Journal Title

      Int J Urol

      Volume: 23 Issue: 3 Pages: 204-210

    • DOI

      10.1111/iju.13015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Xp11.2転座型腎細胞癌で認めるキメラTFE3転写因子の機能解析2018

    • Author(s)
      馬場理也、元島崇信、馬文娟、蓮見壽史 黄瑩、佐藤賢文、宮里パオラ、倉橋竜馬、 長嶋洋治、古屋充子、矢尾正祐 尾池雄一、神波大己
    • Organizer
      第106回日本泌尿器科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of mutations in chromatin remodeling genes2018

    • Author(s)
      Jikuya R, Furuya M, Baba M, Aburatani H, Metwalli AR, Schmidt LS, Linehan M, Yao M, Hasumi H
    • Organizer
      American Association for Cancer Research Annual Meeting 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of chimeric TFE3 transcription factors found in Xp11.2 translocation renal cell carcinoma2018

    • Author(s)
      Motoshima T, Satou Y, Miyazato P, Hasumin H, Huang Y, Kadomatsu T, Yao M, Nagashima Y, Furuya M, Oike Y, Schmidt L.S., Kamba T, Linehan W.M., Baba M
    • Organizer
      American Urological Association Annual Meeting 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of hypoxia pathway in TFE3 translocation Renal Cell Carcinoma (RCC)2018

    • Author(s)
      Ma W, Motoshima T, Satou Y, Miyazato P, Hasumi H, Huang Y, Kadomatsu T, Kurahashi R, Nakagata N, Oike Y, Schmidt L.S., Kamba T, Linehan W.M., Baba M
    • Organizer
      2nd Kumamoto IRCMS Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Essential role of tumor suppressor Flcn in the regulation of cell proliferation and differentiation through metabolism2018

    • Author(s)
      Masaya Baba
    • Organizer
      2nd Kumamoto IRCMS Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 遺伝性腎癌症候群~その歴史と医学への貢献~2017

    • Author(s)
      馬場理也
    • Organizer
      日本生理人類学会第76 回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Characterization of chimeric TFE3 transcription factors found in Xp11.2 translocation renal cell carcinoma2017

    • Author(s)
      Takanobu Motoshima, Hisashi Hasumi, Huang Ying, Yorifumi Sato, Paola Miyazato, Masahiro Yao, Yoji Nagashima, Mitsuko Furuya, Yuchi Oike, Tomomi Kamba, S Schmidt Laura, Lineha W Marston, Masaya Baba
    • Organizer
      The 76th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular Characteristics of Renal Cell Carcinomas in Patients with Birt-Hogg-Dube Syndrome2017

    • Author(s)
      Mitsuko Furuya, Hasumi Hisashi, Ikuma Kato, Masaya Baba, Yoji Nagashima, Yasuhiro Iribe, Yukio Nakatani, Masahiro Yao
    • Organizer
      The 76th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2017 Annual Research Report
  • [Presentation] BHD関連腎癌の発癌機構解析2017

    • Author(s)
      蓮見壽史、古屋充子、馬場理也、近藤慶一、中井川昇、山本尚吾、辰野健一、油谷浩幸、矢尾正祐
    • Organizer
      第48回腎癌研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sleeping Beauty transposon mutagenesisによるマウス腎癌関連ゲノム変異の解析2017

    • Author(s)
      馬場理也、元島崇信、入江信子、江角千晴、中潟直己、神波大己
    • Organizer
      第48回腎癌研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Xp11転座型腎癌と診断された2症例のレトロスペクティブな解析2017

    • Author(s)
      元島崇信、西澤秀和、馬場理也、古屋充子、加藤生真、神波大己
    • Organizer
      第48回腎癌研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Xp11.2転座腎細胞癌における発癌分子機構の解明2017

    • Author(s)
      馬場理也、元島崇信、蓮見壽史、黄瑩、Laura S. Schmidt、矢尾正祐、長嶋洋治、古屋充子、尾池雄一、江藤正俊、神波大己、W. Marston Linehan
    • Organizer
      第105回日本泌尿器科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TFE3活性化腎細胞癌の診断補助マーカーの探索と評価2017

    • Author(s)
      元島宗信、馬場理也、蓮見壽史、加藤生真、長嶋洋治、黒田直人、高橋 渡、河野吉昭、矢尾正祐、江藤正俊、神波大己、古屋充子
    • Organizer
      第105回日本泌尿器科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Clarification of the molecular mechanism for cancer development in Xp11.2 translocation renal cell carcinoma2017

    • Author(s)
      Masaya Baba, Ying Huang, Takanobu Motoshima, Hisashi Hasumi, Mitsuko Furuya, Yukiko Hasumi, Masahiro Yao, Yuichi Oike, Tomomi Kamba, Laura S. Schmidt, W. Marston Linehan
    • Organizer
      American Association for Cancer Research Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GPNMBはTFE3活性化腎細胞癌の診断マーカーとして有用である2016

    • Author(s)
      馬場理也、古屋充子、蓮見壽史、加藤生真、長嶋洋治、黒田直人、高橋 渡、河野吉昭、元島宗信、矢尾正祐、江藤正俊
    • Organizer
      第68回西日本泌尿器科学会総会
    • Place of Presentation
      小倉
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Birt-Hogg-Dube症候群における腎癌の分子病理学的検討2016

    • Author(s)
      古屋 充子、入部 康弘、蓮見 壽史、馬場 理也、長嶋 洋治、加 藤 生真、中谷 行雄、矢尾 正祐
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Birt-Hogg-Dube症候群患者腎癌における mTOR シグナル分子の 局在と発現レベルの解析2016

    • Author(s)
      川上 兼堂、入部 康弘、矢尾 正祐、蓮見 壽史、馬場 理也、長 嶋 洋治、中谷 行雄、古屋 充子
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Birt-Hogg-Dube症候群患者における腎がん以外の諸臓器腫瘍に関する病理学的検討2016

    • Author(s)
      中谷 行雄、矢尾 正祐、蓮見 壽史、長嶋 洋治、馬場 理也、野 村 文夫、加藤 生真、古屋 充子
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] GPNMBはTFE3活性化腎細胞癌の診断マーカーとして有用である2016

    • Author(s)
      馬場理也、古屋充子、蓮見壽史、黄 瑩、加藤生真、Martin Lang、長嶋洋治、黒田直人、入江信子、江角千晴、羽野博之、高橋渡、河野吉昭、杉山豊、田上憲一郎、山口隆大、Laura S. Schmidt、江藤正俊、中谷行雄、矢尾正祐、W. Marston Linehan
    • Organizer
      第47回腎癌研究会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腎癌抑制遺伝子FLCNにおけるミスセンス変異の病原性についての検討2016

    • Author(s)
      蓮見壽史、馬場理也、古谷充子、矢尾正祐
    • Organizer
      第47回腎癌研究会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] Clarification of the molecular mechanism for cancer development in Xp11.2 translocation renal cell carcinoma.2015

    • Author(s)
      馬場理也, 黄 瑩, 蓮見壽史, 矢尾正祐, 長嶋洋治, 古屋充子, 尾池雄一, 江藤正俊, Laura S Schmidt, W Marston Linehan
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腎癌の代謝径路におけるFLCN/FNIP1/FNIP2遺伝子群の重要性2015

    • Author(s)
      蓮見壽史, 馬場理也,古屋充子, 矢尾正祐
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Birt-Hogg-Dube症候群における肺腫瘍発生の病理学的検討2015

    • Author(s)
      中谷行雄, 奥寺康司, 入部康弘, 矢尾正祐, 蓮見壽史, 長嶋洋治, 馬場理也, 野村文夫, 古屋充子
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Birt-Hogg-Dube症候群100家系における臨床病理像の特徴と腎癌およびその他の悪性腫瘍発症率の検討2015

    • Author(s)
      古屋充子, 入部康弘, 矢尾正祐, 蓮見壽史, 長嶋洋治, 馬場理也, 野村文夫, 中谷行雄
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Birt-Hogg-Dube症候群に発症する腎癌の臨床病理像, 遺伝子変異および網羅的染色体解析2015

    • Author(s)
      入部康弘, 矢尾正祐, 蓮見壽史, 長嶋洋治, 馬場理也, 野村文夫, 中谷行雄, 古屋充子
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Folliculin-interacting protein, FNIP1および2の腎臓における役割2015

    • Author(s)
      蓮見壽史, 馬場理也,古屋充子, 矢尾正祐
    • Organizer
      第80回日本泌尿器科学会東部総会
    • Place of Presentation
      東京都
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Xp11.2 translocation RCC mouse model.2015

    • Author(s)
      Baba M, Huang Y, Hasumi H, Furuya M, Hasumi Y, Yao M, Schmidt LS, Linehan WM.
    • Organizer
      6th BHD Symposium
    • Place of Presentation
      Syracuse, U.S.A.
    • Year and Date
      2015-09-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FLCN結合蛋白FNIP1およびFNIP2の腎臓における役割2015

    • Author(s)
      蓮見壽史,馬場理也,古屋充子,矢尾正祐
    • Organizer
      第46回腎癌研究会
    • Place of Presentation
      東京都
    • Year and Date
      2015-07-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Xp11.2転座腎細胞癌発癌機構の解明2015

    • Author(s)
      馬場 理也,蓮見 壽史,黄 瑩,入江 信子,長嶋 洋治,矢尾 正祐,江藤 正俊,尾池 雄一,須田 年生,W. Marston Linehan
    • Organizer
      第46回腎癌研究会
    • Place of Presentation
      東京都
    • Year and Date
      2015-07-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 癌抑制遺伝子産物FLCNの生体における多様な働き2015

    • Author(s)
      馬場 理也
    • Organizer
      第10回 Biomedical Frontier TOKAI
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] BHD 症候群関連腎癌の発生メカニズムの解析2015

    • Author(s)
      蓮見壽史,馬場理也,古屋充子,矢尾正祐
    • Organizer
      第21回日本家族性腫瘍学会学術集会
    • Place of Presentation
      埼玉市
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Book] Renal Cell Carcinoma Molecular Features and Treatment Updates, Chapter: Hereditary Renal Cell Carcinoma2017

    • Author(s)
      Masaya Baba, Laura S. Schmidt, W. Marston Linehan
    • Total Pages
      381
    • Publisher
      Springer
    • ISBN
      9784431555308
    • Related Report
      2017 Annual Research Report
  • [Book] Renal Cell Carcinoma - Molecular Features and Treatment Updates(分担執筆, Chapter 2; Hereditary Renal Cell Carcinoma)2017

    • Author(s)
      Baba M, Schmidt LS, Linehan WM
    • Total Pages
      64
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] Year Book of RCC 2016 (分担執筆,がんの不均一性と進化・進展)2017

    • Author(s)
      馬場理也、江藤正俊
    • Total Pages
      11
    • Publisher
      メディカルビュー社
    • Related Report
      2016 Annual Research Report
  • [Book] 実験医学 (分担執筆, 腎がん発生の分子メカニズムー腎がん研究からわかってきたがんの病態基盤ー)2016

    • Author(s)
      馬場理也
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2016 Annual Research Report
  • [Remarks]

    • URL

      http://ircms.kumamoto-u.ac.jp/publications/2016/06/loss-of-folliculin-disrupts-hematopoietic-stem-cell-quiescence-and-homeostasis-resulting-in-bone-mar-1.html

    • Related Report
      2016 Annual Research Report
  • [Remarks]

    • URL

      http://researchmap.jp/7000016636/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-10-07  

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