Regulatory mechanism of microenvironment at fetomaternal interface by lipid mediators and progesterone
| Project/Area Number |
15H04979
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Fujii Tomoyuki 東京大学, 医学部附属病院, 教授 (40209010)
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| Co-Investigator(Kenkyū-buntansha) |
廣田 泰 東京大学, 医学部附属病院, 講師 (40598653)
永松 健 東京大学, 医学部附属病院, 准教授 (60463858)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 脂質メディエーター / 胎盤 / 妊娠高血圧症候群 / リゾホスファチジン酸 / 子宮内膜 / プロゲステロン / 着床 / 微小環境 / 絨毛細胞 / 妊娠 / リゾリン脂質 / 周産期 / 脂質 / 胎盤形成 |
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| Outline of Final Research Achievements |
The involvement of lysophosphatidic acid (LPA) signaling pathway in the regulation of trophoblast cell activities and placental function was investigated. We found that the serum level of autotaxin (ATX), a secretory enzyme essential for LPA production was remarkably elevated in pregnant women and that the placenta was a major source of ATX. In-vitro study revealed that LPA signaling induced the expression of the genes related to angiogenesis, immune modulation and cell differentiation in trophoblast cells. Abnormal expression pattern of the molecules associated with LPA signaling was observed in the placentas complicated with preeclampsia and fetal growth restriction, suggesting the relevance of deranged LPA signaling to pathoetiology of those diseases. Our findings propose that LPA signaling pathway can be a therapeutic target for preeclampsia and recurrent pregnancy loss.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro2017
Author(s)
Kenichiro Motomura, Naoko Okada, Hideaki Morita, Mariko Hara, Masato Tamari, Keisuke Orimo, Go Matsuda, Ken-Ichi Imadome, Akio Matsuda, Takeshi Nagamatsu, Mikiya Fujieda, Haruhiko Sago, Hirohisa Saito, and Kenji Matsumoto
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Journal Title
PLOS ONE
Volume: in press
Issue: 5
Pages: e0177994-e0177994
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition.2017
Author(s)
Hashimoto A, Iriyama T, Sayama S, Nakayama T, Komatsu A, Miyauchi A, Nishii O, Nagamatsu T, Osuga Y, Fujii T1
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Journal Title
J Mater Fetal Neonata Med
Volume: 印刷中
Issue: 3
Pages: 364-369
DOI
Related Report
Peer Reviewed
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