Pathogenesis and new treatment for eye deformity due to pathologic myopia

• Project/Area Number: 15H04993
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OHNO-MATSUI Kyoko 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30262174)
• Co-Investigator(Kenkyū-buntansha): 吉田 武史 東京医科歯科大学, 医学部附属病院, 助教 (30451941) ; 森田 育男 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (60100129) ; 諸星 計 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60598415)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 眼細胞生物学 / 病的近視

Outline of Final Research Achievements

In the eyes with pathologic myopia, the deformity of posterior segment of the globe mechanically damages the retina and the optic nerve. In the present study, we have established novel models of experimental myopia by visual deprivation in rats. To prevent the scleral thinning and myopia progression, human skin-derived fibroblasts were transplanted along the outer surface of rat sclera before inducing myopia. In 1 week, the transplanted cells produced collagen in situ, and the recipient sclera had an increased thickness. In transplanted animals, the degree of induced myopia was less. The results showed that autologous fibroblast transplantation can be a novel, less-invasive therapy to prevent eye deformity in pathologic myopia.

Research Products

• [Int'l Joint Research] シンガポール国立眼研究所(シンガポール)
• [Journal Article] SURGICAL OUTCOMES AFTER INVERTED INTERNAL LIMITING MEMBRANE FLAP VERSUS CONVENTIONAL PEELING FOR VERY LARGE MACULAR HOLES (2018)
  • Author(s): Narayanan Raja、Singh Sumit R.、Taylor Stanford、Berrocal Maria H.、Chhablani Jay、Tyagi Mudit、Ohno-Matsui Kyoko、Pappuru Rajeev R.、Apte Rajendra S.
  • Journal Title: Retina Volume: - Issue: 8 Pages: 1-1
  • DOI: 10.1097/iae.0000000000002186
• [Journal Article] Progression of Myopic Maculopathy during 18-Year Follow-up (2018)
  • Author(s): Fang Yuxin、Yokoi Tae、Nagaoka Natsuko、Shinohara Kosei、Onishi Yuka、Ishida Tomoka、Yoshida Takeshi、Xu Xian、Jonas Jost B.、Ohno-Matsui Kyoko
  • Journal Title: Ophthalmology Volume: - Issue: 6 Pages: 863-877
  • DOI: 10.1016/j.ophtha.2017.12.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ten-Year Progression of Myopic Maculopathy (2018)
  • Author(s): Yan Yan Ni、Wang Ya Xing、Yang Yan、Xu Liang、Xu Jie、Wang Qian、Yang Jing Yan、Yang Xuan、Zhou Wen Jia、Ohno-Matsui Kyoko、Wei Wen Bin、Jonas Jost B.
  • Journal Title: Ophthalmology Volume: -- Issue: 8 Pages: 1253-1263
  • DOI: 10.1016/j.ophtha.2018.01.035
• [Journal Article] Diagnosis and treatment guideline for myopic choroidal neovascularization due to pathologic myopia (2018)
  • Author(s): Ohno-Matsui Kyoko、Ikuno Yasushi、Lai Timothy Y.Y.、Gemmy Cheung Chui Ming
  • Journal Title: Progress in Retinal and Eye Research Volume: 63 Pages: 92-106
  • DOI: 10.1016/j.preteyeres.2017.10.005
• [Journal Article] Peri-dome Choroidal Deepening in Highly Myopic Eyes With Dome-Shaped Maculas (2017)
  • Author(s): Ohno-Matsui Kyoko、Fang Yuxin、Uramoto Kengo、Shinohara Kosei、Yokoi Tae、Ishida Tomoka、Jonas Jost B.
  • Journal Title: American Journal of Ophthalmology Volume: 183 Pages: 134-140
  • DOI: 10.1016/j.ajo.2017.09.009
• [Journal Article] Posterior Staphylomas in Pathologic Myopia Imaged by Widefield Optical Coherence Tomography (2017)
  • Author(s): Shinohara Kosei、Shimada Noriaki、Moriyama Muka、Yoshida Takeshi、Jonas Jost B.、Yoshimura Nagahisa、Ohno-Matsui Kyoko
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 58 Issue: 9 Pages: 3750-3750
  • DOI: 10.1167/iovs.17-22319
• [Journal Article] Macular Bruch’s membrane defect and dome-shaped macula in high myopia (2017)
  • Author(s): Fang Yuxin、Jonas Jost B.、Yokoi Tae、Cao Kejia、Shinohara Kosei、Ohno-Matsui Kyoko
  • Journal Title: PLOS ONE Volume: 12 Issue: 6 Pages: e0178998-e0178998
  • DOI: 10.1371/journal.pone.0178998
• [Journal Article] Detection of posterior vortex veins in eyes with pathologic myopia by ultra-widefield indocyanine green angiography. (2017)
  • Author(s): Moriyama M, Cao K, Ogata S, Ohno-Matsui K.
  • Journal Title: British Journal of Ophthalmology Volume: 印刷中 Issue: 9 Pages: 1179-1184
  • DOI: 10.1136/bjophthalmol-2016-309877
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Features of posterior staphylomas analyzed in wide-field fundus images in patients with unilateral and bilateral pathologic myopia. (2017)
  • Author(s): Ohno-Matsui K, Alkabes M, Salinas C, Mateo C, Moriyama M, Cao K, Yoshida T.
  • Journal Title: Retina Volume: 37 Issue: 3 Pages: 477-486
  • DOI: 10.1097/iae.0000000000001327
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Parapapillary Diffuse Choroidal Atrophy in Children is Associated with Extreme Thinning of Parapapillary Choroid. (2017)
  • Author(s): Yokoi T, Zhu D, Bi HS, Jonas JB, Jonas RA, Nagaoka N, Moriyama M, Yoshida T, Ohno-Matsui K.
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 58 Issue: 2 Pages: 901-906
  • DOI: 10.1167/iovs.16-20652
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Retinal pigment epithelium cell density in relationship to axial length in human eyes. (2017)
  • Author(s): Jonas JB, Ohno-Matsui K, Holbach L, Panda-Jonas S.
  • Journal Title: Acta Ophthalmologica Volume: 95 Issue: 1
  • DOI: 10.1111/aos.13188
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Optic nerve head histopathology in high axial myopia. (2017)
  • Author(s): Jonas JB, Ohno-Matsui K, Panda-Jonas S.
  • Journal Title: Journal of Glaucoma Volume: 26 Issue: 2 Pages: 187-193
  • DOI: 10.1097/ijg.0000000000000574
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Association between axial length and horizontal and vertical globe diameters. (2017)
  • Author(s): Jonas JB, Ohno-Matsui K, Holbach L, Panda-Jonas S.
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology Volume: 255 Issue: 2 Pages: 237-242
  • DOI: 10.1007/s00417-016-3439-2
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Peripapillary arterial ring of Zinn-Haller in highly myopic eyes as detected by optical coherence tomography angiography. (2017)
  • Author(s): Ishida T, Jonas JB, Ishii M, Shinohara K, Ikegaya Y, Ohno-Matsui K.
  • Journal Title: Retina Volume: 37 Issue: 2 Pages: 299-304
  • DOI: 10.1097/iae.0000000000001165
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Establishment of novel therapy to reduce progression of myopia in rats with experimental myopia by fibroblast transplantation on sclera. (2017)
  • Author(s): Shinohara K, Yoshida T, Liu H, Ichinose S, Ishida T, Nakahama K, Nagaoka N, Moriyama M, Morita I, Ohno-Matsui K.
  • Journal Title: Journal of Tissue Engineering and Regenerative Medicine Volume: 印刷中 Issue: 1 Pages: e451-e461
  • DOI: 10.1002/term.2275
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Pathologic Myopia. (2016)
  • Author(s): Ohno-Matsui K.
  • Journal Title: Asia-Pacific Academy of Ophthalmology Volume: 5 Issue: 6 Pages: 415-423
  • DOI: 10.1097/apo.0000000000000230
  • NAID: 10017004953
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Corneal curvature radius in myopia of schoolchildren versus adult myopia. (2016)
  • Author(s): Jonas JB, Bi HS, Wu JF, Xu L, Wang YX, Wei WB, Nangia V, Sinha A, Guo Y, You QS, Ohno-Matsui K, Panda-Jonas S.
  • Journal Title: Cornea Volume: 35 Issue: 10 Pages: 1333-1337
  • DOI: 10.1097/ico.0000000000000854
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] What is the fundamental nature of pathologic myopia? (2016)
  • Author(s): Ohno-Matsui K.
  • Journal Title: Retina Volume: 印刷中 Issue: 6 Pages: 1043-1048
  • DOI: 10.1097/iae.0000000000001348
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Six-year outcomes of intravitreal bevacizumab for choroidal neovascularization in patients with pathologic myopia. (2016)
  • Author(s): Kasahara K, Moriyama M, Morohoshi K, Yoshida T, Simada N, Nagaoka N, Yokoi T, Shinohara K, Kaneko Y, Suga M, Ohno-Matsui K.
  • Journal Title: Retina Volume: 印刷中 Issue: 6 Pages: 1055-1064
  • DOI: 10.1097/iae.0000000000001313
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Peripheral pigmented streaks in eyes with pathologic myopia. (2016)
  • Author(s): Shinohara K, Moriyama M, Shimada N, Yoshida T, Ohno-Matsui K.
  • Journal Title: Retina Volume: 36 Pages: 1573-1578
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Peripapillary diffuse chorioretinal atrophy in children as a sign of eventual pathologic myopia in adults. (2016)
  • Author(s): Yokoi T, Jonas JB, Shimada N, Nagaoka N, Moriyama M, Yoshida T, Ohno-Matsui K.
  • Journal Title: Ophthalmology Volume: 123 Issue: 8 Pages: 1783-1787
  • DOI: 10.1016/j.ophtha.2016.04.029
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Characteristics of peripapillary staphylomas associated with high myopia determined by swept-source optical coherence tomography. (2016)
  • Author(s): Shinohara K, Moriyama M, Shimada N, Yoshida T, Ohno-Matsui K.
  • Journal Title: American Journal of Ophthalmology Volume: 169 Pages: 138-144
  • DOI: 10.1016/j.ajo.2016.06.033
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Education-related parameters in high myopia: Adults versus school children. (2016)
  • Author(s): Jonas JB, Xu L, Wang YX, Bi HS, Wu JF, Jiang WJ, Nangia V, Sinha A, Zhu D, Tao Y, Guo Y, You QS, Wu LJ, Tao LX, Guo XH, Ohno-Matsui K, Panda-Jonas S.
  • Journal Title: PLoS One Volume: 11 Issue: 5 Pages: e0154554-e0154554
  • DOI: 10.1371/journal.pone.0154554
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Macular Bruch's membrane holes in choroidal neovascularization-related myopic macular atrophy by swept-source optical coherence tomography. (2016)
  • Author(s): Ohno-Matsui K, Jonas JB, Spaide RF.
  • Journal Title: American Journal of Ophthalmology Volume: 162 Pages: 133-139
  • DOI: 10.1016/j.ajo.2016.03.019
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Myopic maculopathy and optic disc changes in highly-myopic young Asian eyes and impact on visual acuity. (2016)
  • Author(s): Koh V, Tan C, Tan PT, Tan M, Balla V, Nah G, Ching-Yu C, Ohno-Matsui K, Tan MM, Yang A, Zhao P, Wong TY, Seang-Mei S.
  • Journal Title: American Journal of Ophthalmology Volume: 164 Pages: 69-79
  • DOI: 10.1016/j.ajo.2016.01.005
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Macular Bruch's membrane holes in choroidal neovascularization-related myopic macular atrophy by swept-source optical coherence tomography. (2016)
  • Author(s): Ohno-Matsui K, Jonas JB, Spaide RF.
  • Journal Title: American Journal of Ophthalmology Volume: 162 Pages: 133-139
  • DOI: 10.1016/j.ajo.2015.11.014
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Features of posterior staphylomas analyzed in wide-field fundus images in patients with unilateral and bilateral pathologic myopia. (2016)
  • Author(s): Ohno-Matsui K, Alkabes M, Salinas C, Mateo C, Moriyama M, Cao K, Yoshida T.
  • Journal Title: Retina Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Peripapillary Arterial Ring of Zinn-Haller in Highly Myopic Eyes As Detected by Optical Coherence Tomography Angiography. (2016)
  • Author(s): Ishida T, Jonas JB, Ishii M, Shinohara K, Ikegaya Y, Ohno-Matsui K.
  • Journal Title: Retina Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Updates of pathologic myopia. (2016)
  • Author(s): Ohno-Matsui K, Lai TY, Lai CC, Cheung CM.
  • Journal Title: Progress in Retinal and Eye Research Volume: 52 Pages: 156-187
  • DOI: 10.1016/j.preteyeres.2015.12.001
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 強度近視眼における眼底自発蛍光の応用． (2016)
  • Author(s): 石田友香、大野京子．
  • Journal Title: Monthly Book OCULISTA Volume: 34 Pages: 27-31
• [Journal Article] 強膜． (2016)
  • Author(s): 島田典明、大野京子．
  • Journal Title: あたらしい眼科 Volume: 33 Pages: 229-232
• [Journal Article] 強度近視のぶどう腫の診断基準と分類． (2016)
  • Author(s): 森山無価、大野京子．
  • Journal Title: Monthly Book OCULISTA Volume: 36 Pages: 9-14
• [Journal Article] 眼の先制医療． (2016)
  • Author(s): 木下茂、大野京子．
  • Journal Title: あたらしい眼科 Volume: 33 Pages: 483-483
• [Journal Article] Extreme thinning or loss of inner neural retina along the staphyloma edge in eyes with pathologic myopia. (2015)
  • Author(s): Tanaka Y, Shimada N, Ohno-Matsui K.
  • Journal Title: American Journal of Ophthalmology Volume: 159 Issue: 4 Pages: 677-682
  • DOI: 10.1016/j.ajo.2015.01.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hemodynamics of focal choroidal excavations. (2015)
  • Author(s): Soma R, Moriyama M, Ohno-Matsui K.
  • Journal Title: International Ophthalmology Volume: 35 Issue: 2 Pages: 261-268
  • DOI: 10.1007/s10792-015-0042-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] International photographic classification and grading system for myopic maculopathy. (2015)
  • Author(s): Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CMG, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY, for the META-analysis for Pathologic Myopia (META-PM) Study Group.
  • Journal Title: American Journal of Ophthalmology Volume: 159 Issue: 5 Pages: 877-883
  • DOI: 10.1016/j.ajo.2015.01.022
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Intravitreal Aflibercept Injection in Patients with Myopic Choroidal Neovascularization: The MYRROR Study. (2015)
  • Author(s): Ikuno Y, Ohno-Matsui K, Wong TY, Korobelnik JF, Vitti R, Li T, Stemper B, Asmus F, Zeitz O, Ishibashi T; MYRROR Investigators.
  • Journal Title: Ophthalmology Volume: 122 Issue: 6 Pages: 1220-1227
  • DOI: 10.1016/j.ophtha.2015.01.025
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comparison of clinical features in highly myopic eyes with and without dome-shaped macula Ophthalmology. (2015)
  • Author(s): Liang IC, Shimada N, Tanaka Y, Nagaoka N, Moriyama M, Yoshida T, Ohno-Matsui K.
  • Journal Title: Ophthalmology Volume: 122 Issue: 8 Pages: 1591-1600
  • DOI: 10.1016/j.ophtha.2015.04.012
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Chorioretinal folds in eyes with myopic staphyloma. (2015)
  • Author(s): Ishida T, Shinohara K, Tanaka Y, Moriyama M, Morohoshi K, Shimada N, Yoshida T, Ohno-Matsui K.
  • Journal Title: Am J Ophthalmol. Volume: 160 Issue: 3 Pages: 608-613
  • DOI: 10.1016/j.ajo.2015.05.028
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Glaucomatous-Type Optic Discs in High Myopia. (2015)
  • Author(s): Nagaoka N, Jonas JB, Morohoshi K, Moriyama M, Shimada N, Yoshida T, Ohno-Matsui K.
  • Journal Title: PLoS One. Volume: 10 Issue: 10 Pages: 362-368
  • DOI: 10.1371/journal.pone.0138825
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 視線追跡装置による遮閉眼の位置測定と交代プリズム遮閉試験による眼位の比較． (2015)
  • Author(s): 内田亜梨沙、大野明子、柴田優子、深町雅子、西山友貴、宮後宏美、倉田あゆみ、大野京子．
  • Journal Title: 眼科臨床紀要 Volume: 8 Pages: 492-495
  • Peer Reviewed
• [Journal Article] 低濃度アトロピン点眼の副作用について． (2015)
  • Author(s): 西山友貴、森山無価、深町雅子、内田亜梨沙、宮後宏美、倉田あゆみ、所敬、大野京子．
  • Journal Title: 日本眼科学会雑誌 Volume: 119 Pages: 812-816
  • Peer Reviewed
• [Journal Article] 近視性CNVに対する抗VEGF療法． (2015)
  • Author(s): 笠原香織、大野京子．
  • Journal Title: 眼科グラフィック Volume: 4 Pages: 173-182
• [Journal Article] 増加する近視・強度近視． (2015)
  • Author(s): 川崎良、大野京子．
  • Journal Title: 医学のあゆみ Volume: 253 Pages: 159-161
• [Journal Article] 強度近視． (2015)
  • Author(s): 島田典明、大野京子．
  • Journal Title: 眼科 Volume: 57 Pages: 564-569
• [Journal Article] 病的近視． (2015)
  • Author(s): 大野京子、生野恭司．
  • Journal Title: あたらしい眼科 Volume: 32 Pages: 1373-1374
  • NAID: 10017004953
• [Journal Article] 強度近視の眼合併症． (2015)
  • Author(s): 横井多恵、大野京子．
  • Journal Title: 日本医師会雑誌 Volume: 144 Pages: 1819-1822
• [Journal Article] DRI OCT-1 Atlantis. (2015)
  • Author(s): 島田典明、大野京子．
  • Journal Title: 眼科 Volume: 57 Pages: 1583-1588
• [Presentation] The impact of pathologic myopia on visual impairment in asia and beyond. (2017)
  • Author(s): Ohno-Matsui K.
  • Organizer: 2017 Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2017-03-04
  • Int'l Joint Research / Invited
• [Presentation] Randomized trials on treatment of myopic CNV: MYRROR and RADIANCE. (2017)
  • Author(s): Ohno-Matsui K.
  • Organizer: 2017 Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2017-03-04
  • Int'l Joint Research / Invited
• [Presentation] Imaging in Myopic Maculopathy. (2017)
  • Author(s): Ohno-Matsui K.
  • Organizer: 2017 Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2017-03-04
  • Int'l Joint Research / Invited
• [Presentation] Myopic CNV. (2017)
  • Author(s): Ohno-Matsui K.
  • Organizer: 2017 Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2017-03-04
  • Int'l Joint Research / Invited
• [Presentation] Influence of Myopic Macular Degeneration Severity on Treatment Outcomes of Myopic Choroidal Neovascularization in the MYRROR Study. (2017)
  • Author(s): Ohno-Matsui K.
  • Organizer: 2017 Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2017-03-03
  • Int'l Joint Research / Invited
• [Presentation] Cutting edge of pathologic myopia (2017)
  • Author(s): Ohno-Matsui K, Cheung G, Lai T, Hirakata A
  • Organizer: American Academy of Ophthalmology
  • Int'l Joint Research
• [Presentation] New imaging findings in pathologic myopia (2017)
  • Author(s): Ohno-Matsui K
  • Organizer: American Academy of Ophthalmology
  • Invited
• [Presentation] Ultra-widefield OCT method to advance the visualization of posterior staphylomas and accompanying vitreoretinal changes in pathologic myopia (2017)
  • Author(s): Ohno-Matsui K, Shinohara K
  • Organizer: The Retina Society
  • Int'l Joint Research
• [Presentation] Staphyloma and dome-shaped maculopathy (2017)
  • Author(s): Ohno-Matsui K
  • Organizer: EURETINA congress
  • Int'l Joint Research
• [Presentation] Peripapillary diffuse atrophy is an indicator in children for eventual pathologic myopia in adults. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: 2016 Autumn Meeting of Ophthalmological Society of Taiwan
  • Place of Presentation: Kaohsiung (Taiwan)
  • Year and Date: 2016-11-13
  • Int'l Joint Research / Invited
• [Presentation] 病的近視における失明原因の解明． (2016)
  • Author(s): 須賀 洸希、森山 無価、 長岡 奈都子、大野京子．
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都（京都府京都市）
  • Year and Date: 2016-11-06
• [Presentation] 小児の病的近視患者における脈絡膜の解析． (2016)
  • Author(s): 横井 多恵、Jost Jonas、大西 由花、浦本 賢吾、須賀 洸希、金子 祐一郎、篠原 宏成、長岡 奈都子、森山 無価、島田 典明、吉田 武史、大野 京子．
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都（京都府京都市）
  • Year and Date: 2016-11-04
• [Presentation] 超広角OCTを用いた強度近視眼に生じる後部ぶどう腫の解析． (2016)
  • Author(s): 篠原宏成、大西由花、浦本賢吾、島田典明、大野京子．
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都（京都府京都市）
  • Year and Date: 2016-11-04
• [Presentation] 強度近視患者におけるLacquer crackの特徴． (2016)
  • Author(s): 浦本賢吾、島田典明、大野京子．
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都（京都府京都市）
  • Year and Date: 2016-11-04
• [Presentation] Fundus imaging of Pathologic Myopia. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都（京都府京都市）
  • Year and Date: 2016-11-03
  • Invited
• [Presentation] 病的近視診療の最前線． (2016)
  • Author(s): 大野京子．
  • Organizer: 第7回北海道眼科臨床セミナー
  • Place of Presentation: 京王プラザ札幌（北海道札幌市）
  • Year and Date: 2016-10-23
  • Invited
• [Presentation] 病的近視診療の最前線． (2016)
  • Author(s): 大野京子．
  • Organizer: 第22回網膜硝子体セミナー
  • Place of Presentation: 目黒雅叙園（東京都目黒区）
  • Year and Date: 2016-10-20
  • Invited
• [Presentation] Spectral Domain and Swept Source OCT in the Diagnosis and Management of Vitreoretinal and Uveitic Disorders. (2016)
  • Author(s): Stanga P, Moussa MS, Ohno-Matsui K, Sadda SR.
  • Organizer: American Academy of Ophthalmology 2016
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2016-10-18
  • Int'l Joint Research
• [Presentation] Diagnosis and Management of Complications due to Pathologic Myopia. (2016)
  • Author(s): Ohno-Matsui K, Cheung G, Lai T, Hirakata A.
  • Organizer: American Academy of Ophthalmology 2016
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2016-10-17
  • Int'l Joint Research / Invited
• [Presentation] New Approaches to the Prevention and Treatment of Myopia. (2016)
  • Author(s): Grzybowski A, Repka MX, Koffler BH, Ohno-Matsui K, Trier K, Morgan I, Tan D.
  • Organizer: American Academy of Ophthalmology 2016
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2016-10-17
  • Int'l Joint Research
• [Presentation] Imaging of Pathologic Myopia. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: 3rd International conference on Pathologic Myopia
  • Place of Presentation: ホテルニューオータニ（東京都千代田区）
  • Year and Date: 2016-10-01
  • Int'l Joint Research / Invited
• [Presentation] Pathologic Myopia-cutting edge of this blinding disease. (2016)
  • Author(s): 大野京子．
  • Organizer: YOKOHAMA RETINA NIGHT
  • Place of Presentation: 横浜グランドインターコンチネンタルホテル（神奈川県横浜市）
  • Year and Date: 2016-07-25
  • Invited
• [Presentation] 画像診断が解き明かす病的近視のサイエンス． (2016)
  • Author(s): 大野京子．
  • Organizer: 第33回日本循環学
  • Place of Presentation: アクロス福岡（福岡県福岡市）
  • Year and Date: 2016-07-22
  • Invited
• [Presentation] 近視性脈路膜新生血管に対するラニビズマブ硝子体内注射の4年成績． (2016)
  • Author(s): 大西由花、横井多恵、笠原香織、諸星計、吉田武史、大野京子．
  • Organizer: 第31回東京医科歯科大学眼科学教室同門会集談会
  • Place of Presentation: 東京医科歯科大学（東京都文京区）
  • Year and Date: 2016-07-18
• [Presentation] Features of posterior staphylomas analyzed by wide-field fundus imaging and 3DMRI in patients with pathologic myopia. (2016)
  • Author(s): Ohno-Matsui K, Alkabes M, Mateo C, Moriyama M.
  • Organizer: XXXth Meetinng of the Club Jules Gonin
  • Place of Presentation: Bordeaux (France)
  • Year and Date: 2016-07-07
  • Int'l Joint Research / Invited
• [Presentation] 小児の近視の増加とその対策． (2016)
  • Author(s): 大野京子．
  • Organizer: フォーサム2016 東京・第59回日本コンタクトレンズ学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-07-02
  • Invited
• [Presentation] 病的近視の診療トピックス． (2016)
  • Author(s): 大野京子．
  • Organizer: 取手医師会学術講演会
  • Place of Presentation: 取手北相馬保健医療センター医師会病院（茨城県取手市）
  • Year and Date: 2016-06-27
  • Invited
• [Presentation] Imaging of pathologic myopia. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: Samsung Medical Center Retina Symposium
  • Place of Presentation: Seoul (Korea)
  • Year and Date: 2016-06-25
  • Int'l Joint Research / Invited
• [Presentation] 病的近視の脈絡膜新生血管に対する診断と治療． (2016)
  • Author(s): 大野京子．
  • Organizer: 兵庫県眼科医会主催・第34回淑瞳会学術講演会
  • Place of Presentation: ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2016-06-18
  • Invited
• [Presentation] Optic disc size and visual field defects in high myopia. (2016)
  • Author(s): Nagaoka N, Morohoshi K, Jonas JB, Ohno-Matsui K.
  • Organizer: Association for Research in Vision and Ophthalmology 2016
  • Place of Presentation: Seattle (USA)
  • Year and Date: 2016-05-05
  • Int'l Joint Research
• [Presentation] Evaluation of En-face OCT images in diabetic macular edema with anti-VEGF treatment. (2016)
  • Author(s): Horie S, Ide M,Morohoshi K, Ohno-Matsui K.
  • Organizer: Association for Research in Vision and Ophthalmology 2016
  • Place of Presentation: Seattle (USA)
  • Year and Date: 2016-05-02
  • Int'l Joint Research
• [Presentation] 病的近視診療の最新トピックス． (2016)
  • Author(s): 大野京子．
  • Organizer: 三重県眼科医会総会・集団会プログラム
  • Place of Presentation: 三重県津市
  • Year and Date: 2016-04-17
  • Invited
• [Presentation] High myopia and myopia control forum. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: International Retinal Forum / Annual Meeting of Chinese Ocular Fundus Diseases Society
  • Place of Presentation: Xiamen (China)
  • Year and Date: 2016-04-14
  • Int'l Joint Research / Invited
• [Presentation] Swept-source OCT in pathologic myopia. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: Asia-Pacific Academy of Ophthalmology
  • Place of Presentation: Taiwan (China)
  • Year and Date: 2016-03-25
  • Int'l Joint Research / Invited
• [Presentation] Bruch’s membrane and pathologic myopia. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: Asia-Pacific Academy of Ophthalmology
  • Place of Presentation: Taiwan (China)
  • Year and Date: 2016-03-25
  • Int'l Joint Research / Invited
• [Presentation] Bruch membrane and myopic maculopathy. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: Asia-Pacific Academy of Ophthalmology
  • Place of Presentation: Taiwan (China)
  • Year and Date: 2016-03-24
  • Int'l Joint Research / Invited
• [Presentation] Pathologic Myopia and its complications. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: Asia-Pacific Academy of Ophthalmology
  • Place of Presentation: Taiwan (China)
  • Year and Date: 2016-03-24
  • Int'l Joint Research / Invited
• [Presentation] Analyses of the Presence and Types of Posterior Staphyloma Using Wide-Field Imaging. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: Fourth Annual International Retinal Imaging Symposium
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2016-03-19
  • Int'l Joint Research / Invited
• [Presentation] Examinations of intrasclerally located Zinn-Haller ring by OCT angiography. (2016)
  • Author(s): Ohno-Matsui K.
  • Organizer: 39th Annual Macula Society Meeting
  • Place of Presentation: Miami (USA)
  • Year and Date: 2016-02-24
  • Int'l Joint Research / Invited
• [Presentation] OCT angiography for choroidal neovascularization due to pathologic myopia. (2016)
  • Author(s): Ohno-Matsui K, Ishida T.
  • Organizer: 39th Annual Macula Society Meeting
  • Place of Presentation: Miami (USA)
  • Year and Date: 2016-02-23
  • Int'l Joint Research / Invited
• [Presentation] 病的近視による眼合併症の診断と治療． (2016)
  • Author(s): 大野京子．
  • Organizer: 第2回TMDU眼科診療連携の会
  • Place of Presentation: 東京
  • Year and Date: 2016-01-21
  • Invited
• [Presentation] 病的近視の重要性． (2016)
  • Author(s): 大野京子．
  • Organizer: 第1回近視研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-01-16
  • Invited
• [Presentation] 病的近視診療の最前線． (2015)
  • Author(s): 大野京子．
  • Organizer: 第19回奈良県黄斑疾患研究会
  • Place of Presentation: 奈良
  • Year and Date: 2015-11-19
  • Invited
• [Presentation] Swept-Source OCT. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: American Academy of Ophthalmology 2015
  • Place of Presentation: Las Vegas (USA)
  • Year and Date: 2015-11-14
  • Int'l Joint Research / Invited
• [Presentation] Clinician scientistを目指す後輩へのエール． (2015)
  • Author(s): 大野京子．
  • Organizer: 横浜市立大学大学院医学セミナー
  • Place of Presentation: 横浜
  • Year and Date: 2015-11-10
  • Invited
• [Presentation] 病的近視診療における最新の知見． (2015)
  • Author(s): 大野京子．
  • Organizer: 第3回中国四国レチナミーティング
  • Place of Presentation: 岡山
  • Year and Date: 2015-11-07
  • Invited
• [Presentation] 生涯より良くみえるためには？． (2015)
  • Author(s): 大野京子．
  • Organizer: 平成27年度第5回都医学研都民講座『目を老化から守るために』
  • Place of Presentation: 東京
  • Year and Date: 2015-11-06
  • Invited
• [Presentation] 病的近視診療の最前線． (2015)
  • Author(s): 大野京子．
  • Organizer: 第5回関西眼科フォーラム
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-01
  • Invited
• [Presentation] 病的近視診療の最前線． (2015)
  • Author(s): 大野京子．
  • Organizer: 第17回教育フォーラム
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-31
  • Invited
• [Presentation] 病的近視の目の神秘を探る旅へ． (2015)
  • Author(s): 大野京子．
  • Organizer: 第69回日本臨床眼科学会ランチョンセミナー、第11回強度近視眼底研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-23
  • Invited
• [Presentation] より深くより鮮明に：Swept Source OCTの新しい可能性を探る． (2015)
  • Author(s): 大野京子．
  • Organizer: 第69回日本臨床眼科学会モーニングセミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-23
  • Invited
• [Presentation] Pathology of high myopia. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: European Association for Vision and Eye Research(EVER)2015
  • Place of Presentation: Nice (France)
  • Year and Date: 2015-10-09
  • Int'l Joint Research / Invited
• [Presentation] Myopia-associated changes of the optic disc. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: European Association for Vision and Eye Research(EVER)2015
  • Place of Presentation: Nice (France)
  • Year and Date: 2015-10-08
  • Int'l Joint Research / Invited
• [Presentation] 病的近視診療の最前線． (2015)
  • Author(s): 大野京子．
  • Organizer: 第186回埼京眼科学術集会
  • Place of Presentation: 川越
  • Year and Date: 2015-10-03
  • Invited
• [Presentation] 病的近視による脈絡膜新生血管（近視性CNV）の診断と治療． (2015)
  • Author(s): 大野京子．
  • Organizer: 第51回日本眼光学学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2015-09-27
  • Invited
• [Presentation] 病的近視診療の最新トピックス． (2015)
  • Author(s): 大野京子．
  • Organizer: 平成27年度近畿ブロック夏期講習会
  • Place of Presentation: 奈良
  • Year and Date: 2015-08-30
  • Invited
• [Presentation] Imaging of pathologic myopia. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: The 9th Congress of Asia-Pacific Vitreo-retina Society(APVRS).
  • Place of Presentation: Sydney (Austlaria)
  • Year and Date: 2015-08-01
  • Int'l Joint Research / Invited
• [Presentation] Identifying prognostic factors for visual outcomes in patients with choroidal neovascularization secondary to pathological myopia: findings from the MIRROR study. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: The 9th Congress of Asia-Pacific Vitreo-retina Society
  • Place of Presentation: Sydney (Austlaria)
  • Year and Date: 2015-08-01
  • Int'l Joint Research / Invited
• [Presentation] 病的近視の脈絡膜新生血管に対する診断と治療． (2015)
  • Author(s): 大野京子．
  • Organizer: 千葉臨床眼科フォーラム
  • Place of Presentation: 幕張
  • Year and Date: 2015-07-18
  • Invited
• [Presentation] 病的近視の今昔：治らない変性疾患から治療、そして予防できる疾患へ． (2015)
  • Author(s): 大野京子．
  • Organizer: 第6回千代田眼科夏のフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2015-07-10
  • Invited
• [Presentation] 病的近視診療の進歩． (2015)
  • Author(s): 大野京子．
  • Organizer: 第30回とやま眼科学術講演会
  • Place of Presentation: 富山
  • Year and Date: 2015-06-27
  • Invited
• [Presentation] Scleral and Choroidal Imaging. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: 2nd international conference of pathologic myopia (iPM)
  • Place of Presentation: Kyoto (Japan)
  • Year and Date: 2015-06-20
  • Int'l Joint Research / Invited
• [Presentation] Definition of PM - followed by consensus discussion. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: 2nd international conference of pathologic myopia (iPM)
  • Place of Presentation: Kyoto (Japan)
  • Year and Date: 2015-06-19
  • Int'l Joint Research / Invited
• [Presentation] Key Note Speech - What is the fundamental nature of PM? - a short excursion into histology, morphology and 3D anatomy. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: 2nd international conference of pathologic myopia (iPM)
  • Place of Presentation: Kyoto (Japan)
  • Year and Date: 2015-06-19
  • Int'l Joint Research / Invited
• [Presentation] Myopic maculopathy-update on its understanding and management. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: Update on high myopia and its associated disease.
  • Place of Presentation: Taipei (Taiwan)
  • Year and Date: 2015-06-13
  • Int'l Joint Research / Invited
• [Presentation] Optic Disc Shape and Visual Field Defects in Eyes with Pathologic Myopia. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: World Glaucoma Congress 2015
  • Place of Presentation: Hong Kong (China)
  • Year and Date: 2015-06-09
  • Int'l Joint Research / Invited
• [Presentation] Updates on Myopic CNV. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: SNEC(Singapore National Eye Centre) 25th ANNIVERSARY INTERNATIONAL MEETING.
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2015-05-22
  • Int'l Joint Research / Invited
• [Presentation] Imaging & Management Decisions in Complications Associated with Pathological Myopia. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: SNEC(Singapore National Eye Centre) 25th ANNIVERSARY INTERNATIONAL MEETING.
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2015-05-22
  • Int'l Joint Research / Invited
• [Presentation] Wide-field fundus imaging for pathologic myopia. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: SNEC(Singapore National Eye Centre) 25th ANNIVERSARY INTERNATIONAL MEETING.
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2015-05-22
  • Int'l Joint Research / Invited
• [Presentation] 後部ぶどう腫と近視性網膜脈絡膜萎縮． (2015)
  • Author(s): 大野京子．
  • Organizer: 第119回日本眼科学会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-19
  • Invited
• [Presentation] 病的近視のOCTと病理所見の対比． (2015)
  • Author(s): 大野京子．
  • Organizer: 第119回日本眼科学会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-18
  • Invited
• [Presentation] 病的近視の眼底病変． (2015)
  • Author(s): 大野京子．
  • Organizer: 第119回日本眼科学会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-17
  • Invited
• [Presentation] Lamina Cribrosa Changes in Myopia: Implications in Glaucoma Diagnosis and Monitoring. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: 30th APAO(Asia-Pacific Academy of Ophthalmology)
  • Place of Presentation: Guangzhou (China)
  • Year and Date: 2015-04-04
  • Int'l Joint Research / Invited
• [Presentation] Visual Outcomes in Patients with Myopic Choroidal Neovascularisation Receiving Intravitreal Aflibercept Injection. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: 30th APAO(Asia-Pacific Academy of Ophthalmology)
  • Place of Presentation: Guangzhou (China)
  • Year and Date: 2015-04-02
  • Int'l Joint Research / Invited
• [Presentation] Pathological Consequences of High Myopia. (2015)
  • Author(s): Ohno-Matsui K.
  • Organizer: 30th APAO(Asia-Pacific Academy of Ophthalmology)
  • Place of Presentation: Guangzhou (China)
  • Year and Date: 2015-04-01
  • Int'l Joint Research / Invited
• [Book] 専門医のための眼科診療クオリファイ28 近視の病態とマネジメント． (2016)
  • Author(s): 大野京子（編集）
  • Total Pages: 300
  • Publisher: 中山書店
• [Book] 今日の治療指針 私はこう治療している 2016 (2016)
  • Author(s): 大野京子
  • Total Pages: 2092
  • Publisher: 医学書院
• [Book] アンチエイジング医学の基礎と臨床 (2015)
  • Author(s): 吉田武史、大野京子．
  • Total Pages: 447
  • Publisher: メジカルビュー社
• [Book] Fundus Autofluorenscence. (2015)
  • Author(s): Ohno-Matsui K.
  • Total Pages: 463
  • Publisher: Wolters Kluwer
• [Book] Myopia and Glaucoma. (2015)
  • Author(s): Ohno-Matsui K.
  • Total Pages: 113
  • Publisher: Springer