| Project/Area Number |
15H04993
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHNO-MATSUI Kyoko 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30262174)
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| Co-Investigator(Kenkyū-buntansha) |
吉田 武史 東京医科歯科大学, 医学部附属病院, 助教 (30451941)
森田 育男 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (60100129)
諸星 計 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60598415)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 眼細胞生物学 / 病的近視 |
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| Outline of Final Research Achievements |
In the eyes with pathologic myopia, the deformity of posterior segment of the globe mechanically damages the retina and the optic nerve. In the present study, we have established novel models of experimental myopia by visual deprivation in rats. To prevent the scleral thinning and myopia progression, human skin-derived fibroblasts were transplanted along the outer surface of rat sclera before inducing myopia. In 1 week, the transplanted cells produced collagen in situ, and the recipient sclera had an increased thickness. In transplanted animals, the degree of induced myopia was less. The results showed that autologous fibroblast transplantation can be a novel, less-invasive therapy to prevent eye deformity in pathologic myopia.
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