| Project/Area Number |
15H04997
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Ogura Yuichiro 名古屋市立大学, 大学院医学研究科, 教授 (70191963)
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| Co-Investigator(Kenkyū-buntansha) |
野崎 実穂 名古屋市立大学, 大学院医学研究科, 講師 (00295601)
安川 力 名古屋市立大学, 大学院医学研究科, 准教授 (00324632)
植村 明嘉 名古屋市立大学, 大学院医学研究科, 教授 (30373278)
平野 佳男 名古屋市立大学, 医学(系)研究科(研究院), 助教 (40405163)
吉田 宗徳 名古屋市立大学, 大学院医学研究科, 准教授 (60273447)
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| Research Collaborator |
Koh Gou Young
Kim Pilhan
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 糖尿病網膜症 / ペリサイト / 内皮細胞 / マクロファージ / VEGF-A / PlGF / Angiopoietin-2 / 炎症 / 線維化 / イメージング / VEGF |
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| Outline of Final Research Achievements |
In diabetic retinopathy (DR), dropout of pericytes from capillary walls is assumed to initiate various vascular dysfunctions, including blood-retina barrier breakdown. However, hyperglycemic mice fail to reproduce retinal pathology characteristic of DR. In this research project, we established a new mouse model of DR in adult mice, by transiently inhibiting pericyte recruitment to developing retinal vessels during neonatal periods following single intraperitoneal injections of an anti-PDGFRβ antibody. Furthermore, we uncovered that endothelial cells and macrophages formed a cycle of vessel damage via VEGF-A, PlGF, and angiopoietin-2 in pericyte-deficient retinal vessels.
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