| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Perioperative change in serum double-strand DNA (dsDNA) as a marker reflecting neutrophil extracellular trap concentration was studied. Serum samples were collected at baseline, immediately after surgery, and the day after surgery (POD-1). In patients undergoing elective cardiac surgery, serum dsDNA concentration was significantly increased from baseline to immediately after surgery, and they were reduced by POD-1. The difference in serum creatinine concentration between baseline and POD-1 was correlated with dsDNA concentration on POD-1. We also investigated the relationship between serum dsDNA levels and renal function in patients undergoing lung surgery. Although serum dsDNA levels are significantly elevated on POD-1 in these patients, there were no patients diagnosed as acute kidney injury in this cohort. Further studies are needed to determine the relationship between serum dsDNA levels and renal dysfunction.
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