Relationship between perioperative neutrophil extracellular trap formation and organ dysfunction
| Project/Area Number |
15H05004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
UCHIDA Tokujiro 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40262183)
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| Co-Investigator(Kenkyū-buntansha) |
槇田 浩史 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20199657)
三高 千恵子 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師 (20126254)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 細胞外トラップ / 周術期腎障害 / 臓器障害 / 急性腎障害 / 血液凝固 / 好中球 / cell free DNA |
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| Outline of Final Research Achievements |
Perioperative change in serum double-strand DNA (dsDNA) as a marker reflecting neutrophil extracellular trap concentration was studied. Serum samples were collected at baseline, immediately after surgery, and the day after surgery (POD-1). In patients undergoing elective cardiac surgery, serum dsDNA concentration was significantly increased from baseline to immediately after surgery, and they were reduced by POD-1. The difference in serum creatinine concentration between baseline and POD-1 was correlated with dsDNA concentration on POD-1. We also investigated the relationship between serum dsDNA levels and renal function in patients undergoing lung surgery. Although serum dsDNA levels are significantly elevated on POD-1 in these patients, there were no patients diagnosed as acute kidney injury in this cohort. Further studies are needed to determine the relationship between serum dsDNA levels and renal dysfunction.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction.2016
Author(s)
Qi Y, Uchida T, Yamamoto M, Yamamoto Y, Kido K, Ito H, Ohno N, Asahara M, Yamada Y, Yamaguchi O, Mitaka C, Tomita M, Makita K.
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Journal Title
Anesthesiol Res Pract
Volume: 2016
Pages: 2794364-2794364
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Perioperative Elevation in Cell Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction: A Multicenter Observational Study.2015
Author(s)
5.Yamamoto Y, Uchida T, Ito H, Kido K, Yamamoto Y, Yamada Y, Ohno N, Asahara M, Yamaguchi O, Makita K.
Organizer
Anesthesiology 2015
Place of Presentation
San Diego, USA
Year and Date
2015-10-24
Related Report
Int'l Joint Research
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