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Comprehensive Registry of Intensive Cares for OHCA Survival (CRITICAL) Study in Osaka, Japan

Research Project

Project/Area Number 15H05006
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionKyoto University

Principal Investigator

Iwami Taku  京都大学, 環境安全保健機構, 教授 (60437291)

Co-Investigator(Kenkyū-buntansha) 川村 孝  京都大学, 環境安全保健機構, 教授 (10252230)
嶋津 岳士  大阪大学, 医学系研究科, 教授 (50196474)
早川 航一  関西医科大学, 医学部, 講師 (60403086)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords院外心停止 / 救急蘇生学 / 心臓突然死 / 集中治療 / 心肺蘇生 / 病院前救急医療 / 心停止後症候群 / 治療体制
Outline of Final Research Achievements

In this study, we built a database to collect clinical factors including quality of cardiopulmonary resuscitation and treatment at medical facilities to improve treatments and outcomes of out-of-hospital cardiac arrest patients. We have established a database including 12,594 cases by December 2017. In addition, collaborating with 3 fire departments in Osaka Prefecture, the quality of resuscitation by emergency medical service personnel in 2,222 cases have been registered by March 2020. As a result of this study, the optimal treatment strategy for out-of-hospital cardiac arrest patients and clinical factors associated with prognosis are well investigated, and several reports were published in the top international journal such as “Circulation” and “Resuscitation” in the field of resuscitation and cardiology. We believe that these results have led to improved treatment and prevention of out-of-hospital cardiac arrest patients.

Academic Significance and Societal Importance of the Research Achievements

病院の外で突然心停止となった方々に対する救命処置、病院到着後の状態や治療実態、救命・社会復帰に繋がる治療方法や予後予測方法について明らかにした。研究成果はCirculation誌などの蘇生循環器領域のトップジャーナルに掲載されたほか、米国心臓学会や日本救急医学会などの救急領域の学会で報告し、広く情報提供を行った。これらの研究成果は、院外心停止患者に対する最適な治療戦略の構築や予防につながり、院外心停止患者の社会復帰に寄与するものである。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (30 results)

All 2020 2019 2018 2017 2016 2015

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (21 results) (of which Int'l Joint Research: 9 results)

  • [Journal Article] Poor Long-Term Survival of Out-of-Hospital Cardiac Arrest in Children2020

    • Author(s)
      Matsui Satoshi、Sobue Tomotaka、Irisawa Taro、et al, Kitamura Tetsuhisa.
    • Journal Title

      International Heart Journal

      Volume: 61 Issue: 2 Pages: 254-262

    • DOI

      10.1536/ihj.19-574

    • NAID

      130007821518

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2020-03-28
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Low-Flow Duration on Favorable Neurological Outcomes of Extracorporeal Cardiopulmonary Resuscitation After Out-of-Hospital Cardiac Arrest2020

    • Author(s)
      Matsuyama Tasuku、Irisawa Taro、et al、Kitamura Tetsuhisa
    • Journal Title

      Circulation

      Volume: 141 Issue: 12 Pages: 1031-1033

    • DOI

      10.1161/circulationaha.119.044285

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum potassium level on hospital arrival and survival after out-of-hospital cardiac arrest: The CRITICAL study in Osaka, Japan2019

    • Author(s)
      Shida Haruka、Matsuyama Tasuku、et al、Kitamura Tetsuhisa、Kawamura Takashi
    • Journal Title

      European Heart Journal: Acute Cardiovascular Care

      Volume: E-pub ahead of print Issue: 4_suppl Pages: S175-S183

    • DOI

      10.1177/2048872619848883

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra-aortic balloon pump and survival with favorable neurological outcome after out-of-hospital cardiac arrest: A multicenter, prospective propensity score-matched study2019

    • Author(s)
      Kishimori Takefumi、Matsuyama Tasuku、et al、Kitamura Tetsuhisa
    • Journal Title

      Resuscitation

      Volume: 143 Pages: 165-172

    • DOI

      10.1016/j.resuscitation.2019.07.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of age on survival of patients with out‐of‐hospital cardiac arrest transported to tertiary emergency medical institutions in Osaka, Japan2019

    • Author(s)
      Nakamura Fumiko、Kajino Kentaro、Kitamura Tetsuhisa、Daya Mohamud R、Ong Marcus EH、Matsuyama Tasuku、et al.
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 19 Issue: 11 Pages: 1088-1095

    • DOI

      10.1111/ggi.13779

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prognostic impact of serum albumin concentration for neurologically favorable outcome in patients treated with target temperature management after out-of-hospital cardiac arrest: a multicenter prospective study2018

    • Author(s)
      Matsuyama T, Iwami T, Yamada T, Hayakawa K, Yoshiya K, Irisawa T, Abe Y, Nishimura T, Uejima T, Ohishi Y, Kiguchi T, Kishi M, Kishimoto M, Nakao S, Hayashi Y, Sogabe T, Morooka T, Izawa J, Shimamoto T, Hatakeyama T, Fujii T, Sado J, Kawamura T, Shimazu T, Kitamura T
    • Journal Title

      Therapeutic Hypothermia and Temperature Management

      Volume: E-pub ahead of print Issue: 3 Pages: 1-6

    • DOI

      10.1089/ther.2017.0053

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of different target temperatures in targeted temperature management on neurologically favorable outcome after out-of-hospital cardiac arrest: A nationwide multicenter observational study in Japan (the JAAM-OHCA registry)2018

    • Author(s)
      Irisawa Taro、Matsuyama Tasuku、Iwami Taku、Yamada Tomoki、Hayakawa Koichi、Yoshiya Kazuhisa、Noguchi Kazuo、Nishimura Tetsuro、Uejima Toshifumi、Yagi Yoshiki、Kiguchi Takeyuki、Kishimoto Masafumi、Matsuura Makoto、Hayashi Yasuyuki、Sogabe Taku、Morooka Takaya、Kitamura Tetsuhisa、Shimazu Takeshi
    • Journal Title

      Resuscitation

      Volume: 133 Pages: 82-87

    • DOI

      10.1016/j.resuscitation.2018.10.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of serum albumin concentration on favorable neurological outcome after out-of-hospital cardiac arrest (From the CRITICAL Study in Osaka, Japan)2018

    • Author(s)
      Matsuyama T, Iwami T, Yamada T, Hayakawa K, Yoshiya K, Irisawa T, Abe Y, Nishimura T, Uejima T, Ohishi Y, Kiguchi T, Kishi M, Kishimoto M, Nakao S, Hayashi Y, Sogabe T, Morooka T, Izawa J, Shimamoto T, Hatakeyama T, Fujii T, Sado J, Shimazu T, Kawamura T, Kitamura T
    • Journal Title

      The American Journal of Cardiology

      Volume: 121(2) Issue: 2 Pages: 156-161

    • DOI

      10.1016/j.amjcard.2017.10.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cohort profile of Comprehensive Registry of In- Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osama, Japan.2016

    • Author(s)
      1.Yamada T, Kitamura T, Hayakawa K, Yoshiya K, Irisawa T, Abe Y, Ishiro M, Uejima T, Ohishi Y, Kaneda K, Kiguchi T, Kishi M, Kishimoto M, Nakao S, Nishimura T, Hayashi Y, Morooka T, Izawa J, Shimamoto T, Hatakeyama T, Matsuyama T, Kawamura T, Shimazu T, Iwami T.
    • Journal Title

      Journal of Intensive Care.

      Volume: 4(10) Issue: 1 Pages: 1-10

    • DOI

      10.1186/s40560-016-0128-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Examination of Cases of Out-Of-Hospital Cardiac Arrest in Older People Transported to Tertiary Emergency Medical Institutions In Osaka.2019

    • Author(s)
      Nakamura F, Kajino K, Hayakawa K, Kitamura T, Iwami T, Kuwagata Y
    • Organizer
      International Conference on Emergency Medicine
    • Related Report
      2019 Annual Research Report
  • [Presentation] 院外心停止の患者において ECPR 開始前のアシデミアは神経学的予後と関連する.2019

    • Author(s)
      岡田遥平、木口雄之、小池 薫、川村 孝、北村哲久、石見 拓
    • Organizer
      第47回日本救急医学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Association Between Serum Lactate During Cardiopulmonary Resuscitation and Survival in Adult Out-Of-Hospital Cardiac Arrest: A Multicenter Cohort Study (The Critical Study in Osaka, Japan).2019

    • Author(s)
      Norihiro Nishioka, Daisuke Kobayashi, Junichi Izawa, Takeyuki Kiguchi, Tetsuhisa Kitamura, Takashi Kawamura, Taku Iwami
    • Organizer
      American Heart Association Resuscitation Science Symposium 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Association of Academia With Neurological Outcome Among Out-Of-Cardiac Arrest Patients Who Undergo Extracorporeal Cardio-Pulmonary Resuscitation.2019

    • Author(s)
      Yohei Okada, Takeyuki Kiguchi, Tetsuhisa Kitamura, Takashi Kawamura, Taku Iwami
    • Organizer
      American Heart Association Resuscitation Science Symposium 2018
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 院外心停止患者における血清カリウム値と神経学的予後の関係.2018

    • Author(s)
      志田瑶、松山匡、清原康介、岡林里枝、川村孝、北村哲久、石見拓
    • Organizer
      第46回 日本救急医学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Association of serum potassium levels with survival from out-of-hospital.2018

    • Author(s)
      Shida H., Kitamura T., Kawamura T., Iwami T..
    • Organizer
      American Heart Association Resuscitation Science Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Arterial hyperoxia exposure and survival among resuscitated patients with out-of-hospital cardiac arrest. JAAM-OHCA Registry in Japan.2018

    • Author(s)
      Kiguchi T., Kitamura T., Fujimi S., Kawamura T., Iwami T..
    • Organizer
      American Heart Association Resuscitation Science Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大阪府下の3次救急医療機関に搬送された高齢者院外心肺停止例の検討.2018

    • Author(s)
      中村文子、梶野健太郎、早川航一、北村哲久、石見拓、鍬方安行
    • Organizer
      第21回日本臨床救急医学会総会・学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 院外心停止における心拍再開後のPaCO2値と生存転帰に関する検討.2018

    • Author(s)
      梶野健太郎、北村哲久、石見拓、早川航一、中村文子、鍬方安行
    • Organizer
      第21回日本臨床救急医学会総会・学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心拍再開後のPaCO2値の推移と生存転帰に関する検討.2018

    • Author(s)
      梶野健太郎、北村哲久、石見拓、早川航一、中村文子、鍬方安行
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 第1回JAAM多施設共同院外心停止レジストリ成果報告会 The effect of different target temperatures in targeted temperature management on neurologically favorable outcome after OHCA: A nationwide multicenter observational studyy in Japan (the JAAM-OHCA registry).2018

    • Author(s)
      入澤太郎
    • Organizer
      第46回日本救急医学会学術総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 治療的体温管理療法での導入速度についての検討 多施設研究Critical Studyを通じて2017

    • Author(s)
      西村哲郎
    • Organizer
      第45回日本救急医学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 病院外心停止に対する治療目標体温管理療法における目標体温別の予後に関する検討(大阪CRITICAL Study 研究班からの報告)2017

    • Author(s)
      入澤太郎
    • Organizer
      第45回日本救急医学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The Relationship Between the Targeted Temperature of TTM2017

    • Author(s)
      Taro Irisawa
    • Organizer
      Resuscitation Science Symposium, American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Arterial hyperoxia exposure time and survival among resuscitated patients with out-of-hospital cardiac arrest;The CRITICAL study in Osaka, Japan2017

    • Author(s)
      Takeyuki Kiguchi, Tetsuhisa Kitamura, The Osaka CRITICAL Study Investigators, Satoshi Fujimi, Takashi Kawamura, Taku Iwami
    • Organizer
      AHA Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prognistic indicators and outcome prediction model for patients with return of spontaneous circulation from cardiopulmonary arrest: Comprehensive Registry of In Hospital Intensive Care on OHCA Survival(CRITICAL) Study in Osaka, Japan2016

    • Author(s)
      Koichi Hayakawa
    • Organizer
      36th International Symposium on Intensive Care and Emergency Medcine.
    • Place of Presentation
      BrusselsSquare Meeting
    • Year and Date
      2016-03-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Arterial hyperoxia associated with better survival among resuscitated patients with out-of-hospital cardiac arrest.2016

    • Author(s)
      Kiguchi T., Kitamura T., Fujimi S., CRITICAL Study; Kawamura T., Iwami T..
    • Organizer
      American Heart Association Resuscitation Science Symposium
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Survival after Out-of-hospital Cardiac Arrests and Arterial Oxygen Partial Pressure during Cardiopulmonary Resuscitation: The CRITICAL Study in Osaka, Japan.2016

    • Author(s)
      Izawa J., Kitamura T., Hayakawa K., Yamada T., Yoshiya K., Abe Y., Uejima T., Ohishi O., Kiguchi T., Kishi K., Kishimoto M., Nakao S., Nishimura T., Hayashi Y., Morooka T., Sokabe T., Matsuyama T., Shimazu T., Kawamura T, Iwami T..
    • Organizer
      Resuscitation Symposium, American Heart Association Scientific Sessions 2016
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 院外心停止例救命のための効果的救急医療体制・治療ストラテジの構築2015

    • Author(s)
      石見拓
    • Organizer
      第43回日本救急医学会総会 学術集会 OHCA特別委員会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] JAAM OHCAレジストリ プロトコール1:血液ガスデータを中心とした研究プロトコール2015

    • Author(s)
      木口雄之
    • Organizer
      第43回日本救急医学会総会 学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] OHCAレジストリの展望と課題2015

    • Author(s)
      石見拓
    • Organizer
      第18回日本臨床救急医学会総会学術集会 OHCA特別委員会企画 オープンミーティング
    • Place of Presentation
      富山県民会館
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2022-11-04  

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