Mechanism of sublingual immune tolerance induction by cross-talking with gut mucosal immunity
| Project/Area Number |
15H05011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
黒石 智誠 東北大学, 歯学研究科, 講師 (30400261)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHII Naoto 東北大学, 大学院医学系研究科, 教授 (60291267)
TANAKA Yukinori , JSPS特別研究員(PD) (60637958)
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| Research Collaborator |
NAGASHIMA Hiroyuki
LU Lu
SHISHIDO Kaori
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 粘膜免疫 / 免疫寛容 / 舌下免疫 / 腸管免疫 |
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| Outline of Final Research Achievements |
Sublingual immunotherapy (SLIT) is an allergen-specific treatment for allergy. SLIT operates by acting on the sublingual mucosa and increases allergen tolerance with safety and effective effect. However, the underlying immunological mechanism remain unclear. This study aimed at providing evidence that sublingual immune tolerance is induced by cross-talking with gut mucosal immunity. This study showed that after sublingual application of antigen, antigen was captured by macrophages, transferred to migratory dendritic cells, and antigen-specific regulatory T cells were induced in the draining (submandibular) lymph modes. This study also showed that Langerhans cells in sublingual mucosa were not responsible for the induction of sublingual immune tolerance, and that sublingual immune tolerance was related to intestinal immune tolerance.
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Report
(4 results)
Research Products
(12 results)
