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On the regulatory mechanism of hard tissue metabolism by 8-nitro-cGMP

Research Project

Project/Area Number 15H05016
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

Kamijo Ryutaro  昭和大学, 歯学部, 教授 (70233939)

Co-Investigator(Kenkyū-buntansha) 赤池 孝章  東北大学, 医学系研究科, 教授 (20231798)
宮本 洋一  昭和大学, 歯学部, 准教授 (20295132)
山田 篤  昭和大学, 歯学部, 講師 (50407558)
片桐 岳信  埼玉医科大学, 医学部, 教授 (80245802)
Co-Investigator(Renkei-kenkyūsha) TANAKA Sakae  東京大学, 医学系研究科, 教授 (50282661)
Research Collaborator SUZUKI Dai  昭和大学, 歯学部, 講師 (00585797)
YOSHIMURA Kentaro  昭和大学, 歯学部, 助教 (10585699)
FUNATO Sakie  昭和大学, 歯学部, 助教 (20783252)
IZUMIDA Eri  昭和大学, 歯学部, 助教 (70783497)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords軟骨細胞 / 骨芽細胞 / 破骨細胞 / 一酸化窒素 / 活性酸素種 / 8-nitro-cGMP / 骨細胞 / 骨代謝 / 8-NO2-cGMP / S-グアニル化 / 硬組織疾患 / 疾患モデルマウス / 硬組織 / 活性酸素 / はタンパク質S-グアニル / 細胞分化 / 細胞増殖
Outline of Final Research Achievements

We investigated the production and functions of 8-nitro-cGMP, a novel second messenger of nitric oxide and reactive oxygen species, in the cartilage and bone tissues. It had been accepted that cGMP is a mediator of bone growth. In this study, we found that not only cGMP but also 8-nitro-cGMP was produced in chondrocytes in the growth plate cartilage. In addition, 8-nitro-cGMP promoted the proliferation of chondrocytes in the growth plates, which caused enhancement in bone growth. Secondly, we found that production of 8-nitro-cGMP in osteoclast precursor cells after exposure to inflammatory cytokines. Since 8-nitro-cGMP was found to promote osteoclast differentiation, it is suggested that inflammatory bone resorption is explained, at least in part, by increased production of 8-nitro-cGMP under inflammatory conditions.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (102 results)

All 2018 2017 2016 2015 2013 Other

All Journal Article (31 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 27 results,  Open Access: 22 results,  Acknowledgement Compliant: 15 results) Presentation (69 results) (of which Int'l Joint Research: 18 results,  Invited: 3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL2018

    • Author(s)
      Kaneko K.、Miyamoto Y.、Tsukuura R.、Sasa K.、Akaike T.、Fujii S.、Yoshimura K.、Nagayama K.、Hoshino M.、Inoue S.、Maki K.、Baba K.、Chikazu D.、Kamijo R.
    • Journal Title

      Nitric Oxide

      Volume: 72 Pages: 46-51

    • DOI

      10.1016/j.niox.2017.11.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 骨粗鬆症の酸化ストレス病態2018

    • Author(s)
      宮本洋一、金子児太郎、上條竜太郎
    • Journal Title

      実験医学

      Volume: 36 Pages: 837-847

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles2017

    • Author(s)
      Urano-Morisawa Eri、Takami Masamichi、Suzawa Tetsuo、Matsumoto Akifumi、Osumi Noriko、Baba Kazuyoshi、Kamijo Ryutaro
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 4 Pages: e0174940-e0174940

    • DOI

      10.1371/journal.pone.0174940

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] LPS administration increases CD11b+ c-Fms+ CD14+ cell population that possesses osteoclast differentiation potential in mice2017

    • Author(s)
      Enomoto Takuya、Takami Masamichi、Yamamoto Matsuo、Kamijo Ryutaro
    • Journal Title

      Cytotechnology

      Volume: 69 Issue: 3 Pages: 529-537

    • DOI

      10.1007/s10616-017-0094-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage2017

    • Author(s)
      Hoshino Marie、Kaneko Kotaro、Miyamoto Yoichi、Yoshimura Kentaro、Suzuki Dai、Akaike Takaaki、Sawa Tomohiro、Ida Tomoaki、Fujii Shigemoto、Ihara Hideshi、Tanaka Junichi、Tsukuura Risa、Chikazu Daichi、Mishima Kenji、Baba Kazuyoshi、Kamijo Ryutaro
    • Journal Title

      Free Radic Biol Med

      Volume: 110 Pages: 63-71

    • DOI

      10.1016/j.freeradbiomed.2017.05.022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nanoindentation time-dependent deformation/recovery suggestive of methylglyoxal induced glycation in calcified nodules2017

    • Author(s)
      Rodriguez Reena、Yoshimura Kentaro、Shibata Yo、Miyamoto Yoichi、Tanaka Reina、Uyama Risa、Sasa Kiyohito、Suzuki Dai、Miyazaki Takashi、Kamijo Ryutaro
    • Journal Title

      Nanomedicine

      Volume: 13 Issue: 8 Pages: 2545-2553

    • DOI

      10.1016/j.nano.2017.07.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-1β suppresses nephronectin expression in osteoblasts via ERK1/2 and JNK2017

    • Author(s)
      Iezumi Yuka、Yamada Atsushi、Minami Erika、Ikehata Mikiko、Yoshida Yuko、Kato Tadashi、Morimura Naoko、Ogata Hiroaki、Sakashita Akiko、Iijima Takehiko、Chikazu Daichi、Kamijo Ryutaro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 493 Issue: 1 Pages: 773-775

    • DOI

      10.1016/j.bbrc.2017.08.104

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rac1 Dosage Is Crucial for Normal Endochondral Bone Growth2017

    • Author(s)
      Suzuki Dai、Bush Jason R、Bryce Dawn-Marie、Kamijo Ryutaro、Beier Frank
    • Journal Title

      Endocrinology

      Volume: 158 Issue: 10 Pages: 3386-3398

    • DOI

      10.1210/en.2016-1691

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 一酸化窒素の新規シグナル分子8-nitro-cGMP:その骨伸長における役割2017

    • Author(s)
      金子児太郎、宮本洋一、近津大地、上條竜太郎
    • Journal Title

      口腔組織培養学会誌

      Volume: 26 Pages: 1-9

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 細菌性プロテアーゼと歯周病性骨破壊2017

    • Author(s)
      鈴木大、上條竜太郎、宮本洋一
    • Journal Title

      細胞

      Volume: 49 Pages: 559-562

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Extracellular matrix loss in chondrocytes after exposure to interleukin-1β in NADPH oxidase-dependent manner.2017

    • Author(s)
      Funato S, Yasuhara R, Yoshimura K, Miyamoto Y, Kaneko K, Suzawa T, Chikazu D, Mishima K, Baba K, Kamijo R
    • Journal Title

      Cell Tissue Res

      Volume: 368 Issue: 1 Pages: 135-144

    • DOI

      10.1007/s00441-016-2551-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing2017

    • Author(s)
      Yamaguchi T, Hosomichi K, Yano K, Kim Y, Nakaoka H, Kimura R, Otsuka H, Nonaka N, Haga S, Takahashi M, Shirota T, Kikkawa Y, Yamada A, Kamijo R, Park SB, Nakamura M, Maki K, Inoue I
    • Journal Title

      Hum Genome Variation

      Volume: 印刷中 Issue: 1 Pages: 17005-17005

    • DOI

      10.1038/hgv.2017.5

    • NAID

      120006891152

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Wnt/β-catenin signaling activates nephronectin expression in osteoblasts.2017

    • Author(s)
      Ikehata M, Yamada A, Morimura N, Itose M, Suzawa T, Shirota T, Chikazu D, Kamijo R
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 484 Issue: 2 Pages: 231-234

    • DOI

      10.1016/j.bbrc.2017.01.053

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhanced and suppressed mineralization by acetoacetate andβ-hydroxybutyrate in osteoblast cultures.2016

    • Author(s)
      Saito A, Yoshimura K, Miyamoto Y, Yamamoto M, Kamijo R
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 473 Issue: 2 Pages: 537-544

    • DOI

      10.1016/j.bbrc.2016.03.109

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nephronectin Expression Is Up-Regulated by BMP-22016

    • Author(s)
      Kurosawa T, Yamada A, Suzuki D, Morimura N, Sasagane Y, Itabe H, Kamijo R
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 7 Pages: 1211-1215

    • DOI

      10.1248/bpb.b15-00941

    • NAID

      130005160772

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Continuous monitoring of caspase-3 activation induced by propofol in developing mouse brain.2016

    • Author(s)
      Konno A, Nishimura A, Nakayama S, Mochizuki A, Yamada A, Kamijo R, Inoue T, Iijima T
    • Journal Title

      Int J Dev Neurosci

      Volume: 51 Issue: 1 Pages: 42-49

    • DOI

      10.1016/j.ijdevneu.2016.04.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of nephronectin is enhanced by α,25-dihydroxyvitamin D3.2016

    • Author(s)
      Hiranuma K, Yamada A, Kurosawa T, Aizawa R, Suzuki D, Saito Y, Nagahama R, Ikehata M, Tsukasaki M, Morimura N, Chikazu D, Maki K, Shirota T, Takami M, Yamamoto M, Iijima T, Kamijo R
    • Journal Title

      FEBS Open Bio

      Volume: 6 Issue: 9 Pages: 914-918

    • DOI

      10.1002/2211-5463.12085

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Degradation of bradykinin by a metalloendopeptidase from Streptococcus pyogenes.2016

    • Author(s)
      Miyamoto, T., Akaike, T., Kawabata, S., Akuta, T., Taruki, C., Yoshitake, J., Hamada, S., Ota, F., Ikarashi, H., Yoshimura, K., Kamijo, R., Maeda, H.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 58 Issue: 4 Pages: 167-172

    • DOI

      10.1016/j.job.2016.07.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cdc42 is crucial for facial and palatal formation during craniofacial development.2016

    • Author(s)
      Oshima-Nakayama M
    • Journal Title

      Bone Reports

      Volume: 5 Pages: 1-6

    • DOI

      10.1016/j.bonr.2016.01.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rho GTPase protein Cdc42 is critical for postnatal cartilage development.2016

    • Author(s)
      Nagahama R, Yamada A, Tanaka J, Aizawa R, Suzuki D, Kassai H, Yamamoto M, Mishima K, Aiba A, Maki K, Kamijo R.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 470 Issue: 4 Pages: 813-817

    • DOI

      10.1016/j.bbrc.2016.01.111

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bone micro-fragility caused by the mimetic aging processes in α-klotho deficient mice: in situ nanoindentation assessment of dilatational bands2015

    • Author(s)
      Maruyama N., Shibata Y., Mochizuki A., Yamada A., Maki K., Inoue T., Kamijo R., Miyazaki T.
    • Journal Title

      Biomaterials

      Volume: 47 Pages: 62-71

    • DOI

      10.1016/j.biomaterials.2015.01.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways2015

    • Author(s)
      Kurosawa T, Yamada A, Takami M, Suzuki D, Saito Y, Hiranuma K, Enomoto T, Morimura N, Yamamoto M, Iijima T, Shirota T, Itabe H, Kamijo R.
    • Journal Title

      FEBS Open Bio

      Volume: 5 Issue: 1 Pages: 303-307

    • DOI

      10.1016/j.fob.2015.04.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhanced in vitro biological activity generated by surface characteristics of anodically oxidized titanium ― the contribution of the oxidation effect.2015

    • Author(s)
      Wurihan, Yamada A, Suzuki D, Shibata Y, Kamijo R, Miyazaki T
    • Journal Title

      European Cells & Materials

      Volume: 29 Pages: 290-302

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of aging with gene expression profiling in mouse submandibular glands.2015

    • Author(s)
      Saito Y
    • Journal Title

      Genomics Data

      Volume: 5 Pages: 115-119

    • DOI

      10.1016/j.gdata.2015.05.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Localization and osteoblastic differentiation potential of neural crest-derived cells in oral tissues of adult mice.2015

    • Author(s)
      Ono M
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 464 Issue: 4 Pages: 1209-1214

    • DOI

      10.1016/j.bbrc.2015.07.106

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Bone Response to Static Compressive Stress at Bone-Implant Interface: The Pilot Study of Critical Static Compressive stress.2015

    • Author(s)
      Ikumi N, Suzawa T, Yoshimura K, Kamijo R.
    • Journal Title

      Int J Oral Maxillofac Implants

      Volume: - Issue: 4 Pages: 827-833

    • DOI

      10.11607/jomi.3715

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oxygenated Static Preservation of Donation after Cardiac Death Liver Grafts Improves Hepatocyte Viability and Function.2015

    • Author(s)
      Yu, J., Murakami, M., Aoki, T., Jiang, B., Jin Z, Koizumi, T., Kusano, M., Kamijo, R., Miyamoto, Y., Enami, Y., Watanabe, M., Otsuka, K
    • Journal Title

      European Surgical Research

      Volume: 56 Issue: 1-2 Pages: 1-18

    • DOI

      10.1159/000441058

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bropirimine inhibits osteoclast differentiation through production of interferon-β.2015

    • Author(s)
      Suzuki H, Mochizuki A, Yoshimura K, Miyamoto Y, Kaneko K, Inoue T, Chikazu D, Takami M, Kamijo R
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 467 Issue: 1 Pages: 146-151

    • DOI

      10.1016/j.bbrc.2015.09.092

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 口腔顎顔面領域に存在する神経堤由来細胞の成体における分布と細胞分化能 ;新しい骨再生療法の提案2015

    • Author(s)
      高橋正皓、小野美樹、須澤徹夫、吉田寛、宇山理紗、槇宏太郎、上條竜太郎
    • Journal Title

      口腔組織培養学会誌

      Volume: 24 Pages: 1-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨代謝とH2S・RSSシグナル2015

    • Author(s)
      宮本洋一、上條竜太郎
    • Journal Title

      細胞工学

      Volume: 34 Pages: 379-383

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Synthetic Octacalcium Phosphate Enhanced Reparative Dentin Formation via Induction of Odontoblast Differentiation.2013

    • Author(s)
      X Wang, T Suzawa, T Miyauchi, B Zhao, R Yasuhara, T Anada, N Nakamura, O Suzuki, R Kamijo.
    • Journal Title

      J Tissue Eng Regen Med,

      Volume: in press Issue: 11 Pages: 1310-1320

    • DOI

      10.1002/term.1669

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 種々のリン酸カルシウム系骨補填材料が骨細胞分化に与える影響2017

    • Author(s)
      蔡 優広、塩飽由香利、穴田 貴久、宮本洋一、上條竜太郎、高橋 哲、鈴木 治
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 免疫組織学的に解析した骨巨細胞腫における破骨細胞関連因子発現の特徴2017

    • Author(s)
      渋谷 勲, 高見 正道, 中村 茂, 上條 竜太郎
    • Organizer
      第35回日本骨代謝学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TLR7リガンドのR848は悪性黒色腫細胞B16F10の骨浸潤を抑制する2017

    • Author(s)
      馬目 瑶子, 岡本 志奈, 鈴木 裕美子, 二川 美弥, 栗谷 未来, 嘉手納 未季, 上條 竜太郎, 船津 敬弘
    • Organizer
      日本障害者歯科学会. 第34回 総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 鼻甲介に含まれる神経堤由来細胞の骨誘導を応用した口唇口蓋裂に対するバイオリサイクル医療の確立2017

    • Author(s)
      吉田 寛, 須澤 徹夫, 高橋 正皓, 大隅 典子, 山口 徹太郎, 上條 竜太郎, 槇 宏太郎
    • Organizer
      第76回日本矯正歯科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス鼻甲介に含まれる神経堤由来細胞を用いた骨誘導法の確立2017

    • Author(s)
      吉田 寛, 須澤 徹夫, 槇 宏太郎, 上條 竜太郎, 大隅 典子
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 低分子量Gタンパク質Rac1は骨芽細胞分化の負の制御因子である2017

    • Author(s)
      鈴木 大, 山田 篤, 笹 清人, 上條 竜太郎
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] モノカルボン酸トランスポーター1は骨芽細分化の新規制御因子である2017

    • Author(s)
      笹 清人, 吉村 健太郎, 宮本 洋一, 上條 竜太郎
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] モノカルボン酸トランスポーター1(MCT1)の骨芽細胞分化における役割2017

    • Author(s)
      笹 清人, 吉村 健太郎, 宮本 洋一, 上條 竜太郎
    • Organizer
      第 338 回昭和大学学士会例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト歯根膜由来細胞株の確立 Down症候群歯根膜由来細胞とのSDF-1発現解析2017

    • Author(s)
      浅川 剛吉, 宮本 洋一, 吉村 健太郎, 笹 清人, 長谷川 智一, 馬目 瑶子, 上條 竜太郎, 杉山 智美, 帖佐 直幸, 石崎 明, 島田 幸恵
    • Organizer
      日本歯科保存学会 2017 年度春季学術大会(第 146 回)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗ウイルス薬R848は悪性黒色腫細胞B16F10の骨浸潤を抑制する2017

    • Author(s)
      馬目 瑶子, 高見 正道, 船津 敬弘, 上條 竜太郎
    • Organizer
      第54回日本口腔組織培養学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インターロイキン-1β刺激後の軟骨細胞様ATDC5細胞におけるNADPHオキシダーゼに依存した細胞外基質の減少2017

    • Author(s)
      船登 咲映, 馬場 一美, 上條 竜太郎, 安原 理佳, 宮本 洋一, 吉村 健太郎, 美島 健二
    • Organizer
      第54回日本口腔組織培養学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 一生涯噛み続けるために歯周組織を科学する 歯周病原菌・宿主由来プロテアーゼによる骨代謝制御2017

    • Author(s)
      上條 竜太郎
    • Organizer
      第17回日本抗加齢医学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 8-Nitro-cGMP, a downstream signaling molecule of nitric oxide, is a novel regulator of bone metabolism that suppresses mineralization by osteoblasts and enhances differentiation of osteoclasts2017

    • Author(s)
      Kaneko K, Miyamoto Y, Yoshimura K, Akaike T, Ida T, Chikazu D, Kamijo R
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular mechanisms of palatal development controlled by Cdc422017

    • Author(s)
      Minami E, Yamada A, Kamijo R
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establish of expression on differentiation performed periodontal ligament cells derived from human teeth - Comparative analysis that SDF-1alpha regulation of expression on periodontal ligament cells derived from Down syndrome teeth -2017

    • Author(s)
      Asakawa T, Miyamoto Y, Yoshimura K, Sasa K, Manome Y, Kamijo R, Hasegawa T, Chosa N, Ishizaki A, Oikawa M, Sugiyama T, Shiga M, Shimada Y
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Persulfides promote osteoclast differentiation in vitro2017

    • Author(s)
      Tsukuura R, Miyamoto Y, Kaneko K, Oshio A, Iizumi M, Takenaka M, Shirakura K, Chikazu D, Kamijo R
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fragmented hyaluronan plays important roles in loss of extracellular matrix and cell death in chondrocytes in vitro2017

    • Author(s)
      Nagayama K, Yasuhara R, Miyamoto Y, Yoshimura K, Mishima K, Maki K, Kamijo R
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genomic analysis of selective tooth agenesis of mandibular incisors2017

    • Author(s)
      Yamaguchi T, Takahashi M, Kimura R, Otsuka H, Nonaka N, Haga S, Shirota T, Yamada A, Kamijo R, Nakamura M, Maki K, Inoue I
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] R848, a TLR7 ligand, inhibits invasions of B16F10 malignant melanoma in bone2017

    • Author(s)
      Manome Y, Suzuki D, Mochizuki A, Saito E, Sasa K, Yoshimura K, Inoue T, Takami M, Inagaki K, Funatsu T, Kamijo R
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study for cell source of bone of bone regeneration using neural crest-derived cells in nasal conches of adult mice2017

    • Author(s)
      Yoshida H, Suzawa T, Osumi N, Maki K, Kamijo R
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cdc42はPTHシグナルを介し骨軟骨形成を制御している2016

    • Author(s)
      長濱 諒、山田 篤、上條竜太郎、槇 宏太郎
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 疾患特異的iPS細胞を用いた原発性萌出不全発症機序の解析2016

    • Author(s)
      泉田恵理、宮本洋一、山口徹太郎、須澤徹夫、上條竜太郎、槇 宏太郎
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Lyz2-Cre/loxPを用いたIrf8遺伝子欠損は細胞培養系でのみ破骨細胞分化を促進する2016

    • Author(s)
      齋藤愛美、鈴木 大、黒滝大翼、望月文子、須澤徹夫、高見正道、井上富雄、田村智彦、上條竜太郎、稲垣克記
    • Organizer
      第31回 日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 8-NO2-cGMPは骨の伸長を促進する内因性シグナル分子である2016

    • Author(s)
      金子児太郎、星野真理江、宮本洋一、赤池孝章、井田智章、藤井重元、近津大地、馬場一美、上條竜太郎
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-08-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 8-nitro-cGMPは成長板軟骨で産生される骨伸長因子である2016

    • Author(s)
      宮本洋一、金子児太郎、星野真理江、赤池孝章、井田智章、藤井重元、馬場一美、近津大地、上條竜太郎
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-08-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 低分子量Gタンパク質Cdc42はPTHシグナルを介し胎生期および生後成長期の軟骨形成を制御している2016

    • Author(s)
      長濱 諒、山田 篤、槇 宏太郎、上條竜太郎
    • Organizer
      第58回歯科基礎医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] インターロイキン-1βで刺激した軟骨細胞によるNADPH-オキシダーゼに依存した細胞外マトリクスの分解2016

    • Author(s)
      船登咲映、安原理佳、宮本洋一、吉村健太郎、美島健二、馬場一美、上條竜太郎
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] LysM-Cre/loxPによるIrf8欠損は細胞培養系でのみ破骨細胞分化を促進する2016

    • Author(s)
      齋藤愛美、鈴木 大、黒滝大翼、望月文子、須澤徹夫、高見正道、田村智彦、稲垣克記、上條竜太郎
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低分子量Gタンパク質Cdc42は生後成長期の軟骨形成において重要である2016

    • Author(s)
      長濱諒、山田 篤、鈴木 大、槇 宏太郎、上條竜太郎
    • Organizer
      第34回日本骨代謝学会学術集
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Nephronectin は活性型ビタミンD3により発現が誘導される2016

    • Author(s)
      平沼克洋、山田 篤、鈴木 大、長濱 諒、高見正道、上條竜太郎
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Bropirimineはinterferon-βの産生を介して破骨細胞分化を抑制する2016

    • Author(s)
      鈴木啓明, 望月文子, 吉村健太郎, 宮本洋一, 金子児太郎, 近津大地, 高見正道, 上條竜太郎
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Methylglyoxal promotes formation of calcified nodules by mouse osteoblastic MC3T3-E1 cells2016

    • Author(s)
      Rodriguez R, Yoshimura K, Miyamoto Y, Shibata Y, Miyazaki T, Kamijo R
    • Organizer
      第3回アジア太平洋骨代謝学会議
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨巨細胞腫における自然免疫機構を介した破骨細胞形成抑制の解析2016

    • Author(s)
      渋谷 勲、高見正道、安井哲郎、日高 亮、上條竜太郎、中村 茂
    • Organizer
      第2回日本骨免疫学会
    • Place of Presentation
      沖縄県国頭郡恩納村
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] FUNCTIONAL ANALYSIS OF PARATHYROID HORMONE 1 RECEPTOR MUTANTS FOUND IN PRIMARY FAILURE OF TOOTH ERUPTION2016

    • Author(s)
      Izumida E, Miyamoto Y, Yamaguchi T, Kamijo R, Maki K
    • Organizer
      92:nd Congress of the European Orthodontic Society
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 8-Nitro-cGMP promotes elongation of long bones in mice2016

    • Author(s)
      Hoshino M, Kaneko K, Miyamoto Y, Akaike T, Yoshimura K, Suzuki D, Nagayama K, Maki K, Chikazu D, Baba K, Kamijo R
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reactive sulfur species promotes bone elongation2016

    • Author(s)
      Kaneko K, Hoshino M, Miyamoto Y, Yoshimura K, Suzuki D, Tsukuura R, Akaike T, Chikazu D, Baba K, Kamijo R
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immediate expression of NOS2 and monocarboxylate transporter-1-dependent delayed expression of NOX2 are required for interleukin-1β-induced cell death in mouse chondrocytes2016

    • Author(s)
      Yoshimura K, Miyamoto Y, Yamada A, Suzawa T, Kamijo R
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 活性型ビタミンD3によるNephronectinの発現制御機構の解析2016

    • Author(s)
      平沼克洋、上條竜太郎、飯島毅彦
    • Organizer
      第70回日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 顎下腺の加齢に伴う遺伝子変化の解析2016

    • Author(s)
      齊藤芳郎、上條竜太郎、代田達夫
    • Organizer
      第70回日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] TLR7リガンドのR848は悪性黒色腫の骨浸潤を抑制する2016

    • Author(s)
      馬目瑶子、望月文子、高見正道、上條竜太郎
    • Organizer
      第53回 日本口腔組織培養学会学術大会
    • Place of Presentation
      金沢
    • Related Report
      2016 Annual Research Report
  • [Presentation] Lyz2-Cre/loxPによるIrf8遺伝子欠損は細胞培養系でのみ破骨細胞分化を促進する2016

    • Author(s)
      齋藤愛美、鈴木 大、黒滝大翼、望月文子、須澤徹夫、高見正道、井上富雄、Keiko Ozato、田村智彦、上條竜太郎、稲垣克記
    • Organizer
      第328回昭和大学学士会例会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規内因性シグナル分子8-ニトロ-cGMPは骨の伸長を促進する2016

    • Author(s)
      金子児太郎、星野真理江、宮本洋一、宇山理沙、近津大地、上條竜太郎
    • Organizer
      第53回口腔組織培養学会学術大会・総会
    • Place of Presentation
      金沢
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脂肪組織由来再生細胞を応用した膝関節半月板の再生2016

    • Author(s)
      糸瀬昌克、須澤徹夫、鎌谷宇明、嶋根俊和、稲垣克記、上條竜太郎、代田達夫
    • Organizer
      昭和大学学士会例会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cdc42 is critical for cartilage development during endochondral ossification at postnatal stage.2015

    • Author(s)
      Nagahama R, Yamada A, Suzuki D, Maki K, kamijo R
    • Organizer
      2015 ASCB Annual Meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of nephronectin gene expression by 1α, 25-Dyhydroxyvitamin D3.2015

    • Author(s)
      Hiranuma K,Yamada A, Suzuki D, Iijima T, Kamijo R
    • Organizer
      2015 ASCB Annual Meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Missense mutations in parathyroid hormone 1 receptor found in patients having primary failure of tooth eruption cause decreased response to parathyroid hormone.2015

    • Author(s)
      Izumida E, Miyamoto Y, Yamada A, Saito T, Otsu M, Yamaguchi T, Maki K, Kamijo R
    • Organizer
      2015 ASCB Annual Meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phagocyte-type NADPH oxidase-derived reactive oxygen species is crucial for activation of hyaluronidase and degradation of extracellular matrix in chondrocytes stimulated by interleukin-1β.2015

    • Author(s)
      Funato S, Yasuhara R, Miyamoto Y, Yoshimura K, Mishima K, Baba K, Kamijo R
    • Organizer
      2015 ASCB Annual Meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 活性型ビタミンD3による細胞外マトリックスタンパク質Nephronectinの発現制御機構の解明.2015

    • Author(s)
      平沼克洋、山田篤、上條竜太郎、飯島毅彦
    • Organizer
      第62回昭和大学学士会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cdc42遺伝子の生後成長期の軟骨形成における機能解析.2015

    • Author(s)
      長濱諒、山田篤、上條竜太郎、槇宏太郎
    • Organizer
      第62回昭和大学学士会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 疾患特異的iPS細胞を用いた疾患発症機構の解明.2015

    • Author(s)
      泉田恵理、宮本洋一、山口徹太郎、山田 篤、大津 真、上條竜太郎、槇 宏太郎
    • Organizer
      第62回昭和大学学士会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 炎症性軟骨基質減少の分子メカニズムの解明.2015

    • Author(s)
      船登咲映、安原理佳、宮本洋一、吉村健太郎、美島健二、馬場一美、上條竜太郎
    • Organizer
      第62回昭和大学学士会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Nephronectinに対する活性型ビタミンD3の発現制御機構の解析2015

    • Author(s)
      平沼克洋、山田篤、鈴木大、飯島毅彦、上條竜太郎
    • Organizer
      第52回日本口腔組織培養学会学術大会
    • Place of Presentation
      徳島
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cdc42は生後成長期の軟骨形成に重要である.2015

    • Author(s)
      長濱諒、山田篤、鈴木大、上條竜太郎、槇宏太郎
    • Organizer
      第52回日本口腔組織培養学会学術大会
    • Place of Presentation
      徳島
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cdc42 in neural crest derived cells is essential for palatal development.2015

    • Author(s)
      Mutsuko Oshima, Atsushi Yamada, Dai Suzuki, Koutaro Maki, Ryutaro Kamijo
    • Organizer
      ANZBMS 25th Annual Scientific Meeting
    • Place of Presentation
      Tasmania, Australia
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cdc42 is critical for postnatal cartilage development.2015

    • Author(s)
      長濱諒、山田篤、槇宏太郎、上條竜太郎
    • Organizer
      第63回国際歯科研究学会日本部会総会
    • Place of Presentation
      福岡
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interleukin-1βinduces activation of hyaluronidase and degradation of extracellular matrix in murine chondrocytes in a phagocyte-type NADPH oxidase-derived reactive oxygen species-dependent manner.2015

    • Author(s)
      Funato S, Yasuhara R, Miyamoto Y, Yoshimura K, Mishima K, Baba K, Kamijo R
    • Organizer
      第63回国際歯科研究学会日本部会総会
    • Place of Presentation
      福岡
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Expression of nephronection is regulated by 1α, 25-Dyhydroxyvitamin D3.2015

    • Author(s)
      平沼克洋、山田篤、飯島毅彦、上條竜太郎
    • Organizer
      第63回国際歯科研究学会日本部会総会
    • Place of Presentation
      福岡
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 免疫組織学的観点からみた骨巨細胞腫におけるCD11b陽性細胞の意義.2015

    • Author(s)
      渋谷 勲、高見正道、榎本拓哉、松永朗裕、中村 茂、上條竜太郎
    • Organizer
      第30回 日本整形外科学会基礎学術集会
    • Place of Presentation
      富山
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経堤由来細胞に発現するRhoファミリー低分子量Gタンパク質Cdc42は口蓋形成に必須である.2015

    • Author(s)
      大島睦子、山田篤、鈴木大、槇宏太郎、上條竜太郎
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨/インプラント界面の静的圧縮応力に対する骨の反応 –静的圧縮の限界応力に関する研究− .2015

    • Author(s)
      井汲憲治、須澤徹夫、吉村健太郎、上條竜太郎
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生命科学の視点から見る口腔インプラント:骨代謝研究の立場から2015

    • Author(s)
      上條竜太郎
    • Organizer
      公益社団法人 日本口腔インプラント学会 関東・甲信越支部
    • Place of Presentation
      東京
    • Year and Date
      2015-08-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 低分子量Gタンパク質Cdc42は口蓋形成において重要な遺伝子である.2015

    • Author(s)
      大島睦子、山田篤、鈴木大、槙宏太郎、上條竜太郎
    • Organizer
      第33回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 内因性活性イオウ種はマウス軟骨細胞の増殖と骨の伸長を促進した.2015

    • Author(s)
      星野真理江,金子児太郎,宮本洋一,近津大地,馬場一美,上條竜太郎
    • Organizer
      第33回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨巨細胞腫細胞培養系におけるゾレドロン酸とデノスマブの作用機序の相違.2015

    • Author(s)
      渋谷 勲、高見正道、榎本拓哉、上條竜太郎、豊根知明
    • Organizer
      第48回 日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      高松
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 8-ニトロ-cGMPはマウス軟骨細胞の増殖と骨の伸長を促進する新規内因性シグナル分子である.2015

    • Author(s)
      星野真理江、宮本洋一、金子児太郎、赤池孝章、近津大地、馬場一美、上條竜太郎
    • Organizer
      第15回 東京骨関節フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Rhoファミリー低分子量Gタンパク質Rac1およびCdc42の骨・軟骨形成における機能解析.2015

    • Author(s)
      山田篤、鈴木大、上條竜太郎
    • Organizer
      第1回日本骨免疫学会
    • Place of Presentation
      宮古島
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 軟骨形成における恒常活性型Rac1の機能解析.2015

    • Author(s)
      鈴木大、Bush J、上條竜太郎、Beier F
    • Organizer
      第1回日本骨免疫学会
    • Place of Presentation
      宮古島
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 8-ニトロ-cGMPは骨伸長を促進する新規内因性シグナル分子である.2015

    • Author(s)
      星野真理江、宮本洋一、金子児太郎、赤池孝章、近津大地、馬場一美、上條竜太郎
    • Organizer
      第1回日本骨免疫学会
    • Place of Presentation
      宮古島
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cdc42遺伝子の口蓋形成過程における機能解析.2015

    • Author(s)
      大島睦子、山田篤、槇宏太郎、上條竜太郎
    • Organizer
      第69回日本口腔科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
  • [Remarks] 昭和大学歯学部口腔生化学講座

    • URL

      http://www10.showa-u.ac.jp/~oralbio/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 半月板再生用材料及び半月板再生用材料の作製方法2017

    • Inventor(s)
      稲垣克記、須澤徹夫、糸瀬昌克、上條竜太郎、代田達夫、嶋根俊和
    • Industrial Property Rights Holder
      学校法人昭和大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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