| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
In this research project, experiments were carried out to analyze the effect of newly developed water-soluble glycolipid (WSG) on bacterial pneumonia and its mechanism. As a result, the following three things were revealed.1) WSG induced the extracellular release of a net structure containing nucleic acid as a main component in macrophages or neutrophils. Especially in macrophages, it was found that mitochondria-derived nucleic acid was released with little cell death and trapped Streptococcus pneumoniae and Pseudomonas aeruginosa.2) Analysis using inhibitors and knockdown cells suggested that the WSG act on the mincle receptor other than TLR4 receptor.
3) Pneumonia and mortality caused by S. pneumoniae were suppressed by nasal administration of WSG.
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