| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
Cancers that occur frequently in the oral cavity are in a state of low oxygen / low glucose stress because there is not sufficient angiogenesis, and the cancer cells are in a very high metabolic requirement. Under such stress, autophagy is thought to contribute to cell proliferation. In addition, malnutrition leads to accumulation of bad proteins and ER stress-induced survival / proliferation signals are transmitted. One way to overcome oral cancers in a stress tolerant state is to suppress the survival signal transmitted from autophagy or the endoplasmic reticulum and to induce a cell death signal due to strong endoplasmic reticulum stress. In this study, the metabolic stress signal in cancer cells was elucidated.
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