| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
We previously identified Epiprofin(Epfn) as a novel member of Sp transcription factor family that is expressed in certain ectodermal organs, such as teeth, hair follicles, nails and skin. During tooth development, Epfn regulates cell proliferation as well as cell migration at the early stages and cell differentiation in the later mature stage by controlling the phosphorylation of Epfn. We also identified a small molecule that strongly induced the expression of Epfn in dental epithelial cells. We are applying the Epfn -inducible small molecule in enamel biosynthesis of regenerative dentistry.
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