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Establishment of peri-implantitis treatment based on radical disinfection technique

Research Project

Project/Area Number 15H05033
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

Sasaki Keiichi  東北大学, 歯学研究科, 教授 (30178644)

Co-Investigator(Kenkyū-buntansha) 庭野 吉己  東北大学, 歯学研究科, 教授 (40375184)
菅野 太郎  東北大学, 歯学研究科, 教授 (30302160)
中村 圭祐  東北大学, 歯学研究科, 講師 (30431589)
天雲 太一  東北大学, 歯学研究科, 助教 (80451425)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords水酸化ラジカル / インプラント周囲炎 / ラジカル殺菌 / 医療機器
Outline of Final Research Achievements

In this project, in vitro and in vivo tests were performed with an aim of application of radical disinfection technique to treatment for peri-implantitis. In vivo test, where peri-implantitis caused around implants installed in dogs were treated with radical disinfection technique. However, there was no significant difference between the test and control groups. Thus, to find more suitable treatment conditions, in vitro test was additionally performed. The results demonstrated that the radical disinfection technique could recondition the titanium surface that had been previously contaminated by bacteria for subsequent osteoblastic cells. Therefore, future study should focus more on the establishment of treatment condition that enables to acquire re-osseointegration around the implants suffering from peri-implantitis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (2 results)

All 2018 Other

All Int'l Joint Research (1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] イエテボリ大学(スウェーデン)

    • Related Report
      2017 Annual Research Report
  • [Presentation] Reconditioning of biofilm-contaminated titanium surface for osteoblast proliferation by hydroxyl radicals generated via H2O2 photolysis2018

    • Author(s)
      Nakamura K, Shirato M, Tenkumo T, Kanno T, Westerlund A, Ortengren U, Sasaki K, Niwano Y
    • Organizer
      International Symposium for Multimodal Research and Education in IOHS-Liaison 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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