| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
In this study, we investigated the possibility of enhancing periodontal regeneration effect in the cell therapy using mesenchymal stem cells and the cytokine therapy. As a result, it was revealed that fibrin gel and β-3 calcium phosphate (β-TCP) whose granule size was 500-1000 mm were useful as a scaffold for adipose tissue-derived stem cells (ADSC). The proteomic analysis of culture supernatants of ADSC and bone marrow- derived mesenchymal stem cells suggested that Periostin might be involved in periodontal tissue regeneration. In addition, the bone regeneration was observed by application of FGF-2 in the fenestration model of beagle dogs. These results suggested that the combination of cell therapy using stem cells and cytokine therapy might enhance the periodontal tissue regeneration effect.
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