| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We examined two approaches that introduced interconnected macro pores into carbonate apatite (CO3Ap) bone replacement. First, CO3Ap granules were connected using interlocking of brushite crystals precipitated on the granular surface through the reaction with acidic calcium phosphate solution in order to fabricate granular connected porous body. Second, α-tricalcium phosphate granules were connected using interlocking of calcium deficient apatite crystals precipitated on the granular surface through the reaction with water vapor followed by the heating at 1300℃ for 6 hours in order to fabricate granular connected porous body. Both porous bodies were used as precursor for the fabrication of interconnected porous CO3Ap using carbonation based on the dissolution-precipitation reaction. In vivo study using bone defect model of rabbit tibia indicated that the interconnected porous CO3Ap showed higher bone replacement ability than the CO3Ap disk without macro pores.
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