Development of new regeneration therapy using strong osteoplasty protein BMP-9 and cells derived from adipose tissue
Project/Area Number |
15H05036
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Kagoshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
白方 良典 鹿児島大学, 医歯学域歯学系, 准教授 (60359982)
中村 利明 鹿児島大学, 医歯学域附属病院, 講師 (60381183)
瀬名 浩太郎 鹿児島大学, 医歯学域歯学系, 助教 (60701117)
迫田 賢二 鹿児島大学, 医歯学域歯学系, 助教 (70419654)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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Keywords | DFAT / BMP-9 / 歯周病 / 骨組織再生 / 歯周組織再生 / 細胞移植 / 培養上清 / 再生療法 / FK-506 / ADSC |
Outline of Final Research Achievements |
The purpose of this study was development of new regenerative therapy for lost bone tissues due to periodontal and oral disease by using FK506 together with BMP-9 for signal molecules and stem cells (ADSC) and dedifferentiated fat cells(DFAT) which derived from adipose tissue as a source of cell transplant. In vitro study demonstrated that BMP-9 and FK506 costimulation induces promotion of osteoblasts-like differentiation in both rat ADSC and rat DFAT. Furthermore , we demonstrated that rDFAT cells culture supernatant of BMP-9 and FK506 costimulation have bone regenerative potential in rat calvarial defects model.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Prevalence and risk factors for peri-implant diseases in Japanese adult dental patients2017
Author(s)
Ogata Y, Nakayama Y, Tatsumi J, Kubota T, Sato S, Nishida T, Takeuchi Y, Onitsuka T, Sakagami R, Nozaki T, Murakami S, Matsubara N, Tanaka M, Yoshino T, Ota J, Nakagawa T, Ishihara Y, Ito T, Saito A, Yamaki K, Matsuzaki E, Hidaka T, Sasaki D, Yaegashi T, Yasuda T, Shibutani T, Noguchi K他
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Journal Title
Journal of Oral Science
Volume: 59
Issue: 1
Pages: 1-11
DOI
NAID
ISSN
1343-4934, 1880-4926
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Randomized placebo-controlled and controlled non-inferiority phase III trials comparing trafermin, a recombinant human fibroblast growth factor 2, and enamel matrix derivative in periodontal regeneration in intrabony defects.2016
Author(s)
Kitamura M, Akamatsu M, Kawanami M, Furuichi Y, Fujii T, Mori M, Kunimatsu K, Shimauchi H, Ogata Y (他27名)
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Journal Title
J Bone Miner Res
Volume: 31
Issue: 4
Pages: 806-814
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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