| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
To identify oral cancer-associated microRNAs (miRNA), samples (tumor and normal tissue) were analyzed with microRNA microarray. Candidate miRNAs with expression levels that were significantly altered in oral cancer samples or selected from a literature review were identified as Onco-miRNA or Tumor-suppressor miRNA. We found that miR-205-5p functions as a tumor suppressor in oral squamous cell carcinoma (OSCC), that miR-205-5p directly regulates TIMP-2 expression, and that miR-205-5p suppresses pro-MMP-2’s activation by regulating the TIMP-2 expression in OSCC cells. Thus, it may be possible to use miR-205-5p to regulate specific tumor-progressive genes as a novel therapeutic approach to treating OSCC.
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