Functional characterization of oral cancer related microRNA and identification of novel therapeutics
| Project/Area Number |
15H05038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Bukawa Hiroki 筑波大学, 医学医療系, 教授 (80173558)
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| Co-Investigator(Kenkyū-buntansha) |
柳川 徹 筑波大学, 医学医療系, 准教授 (10312852)
正田 純一 筑波大学, 医学医療系, 教授 (90241827)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 口腔がん / microRNA / miR-205-5p / Tumor-suppressor miRNA / microRNA (miRNA) / 転移 / 予後 / microRNA-205-5p / リンパ節転移 / 浸潤能 / TIMP-2 / 網羅的発現解析 |
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| Outline of Final Research Achievements |
To identify oral cancer-associated microRNAs (miRNA), samples (tumor and normal tissue) were analyzed with microRNA microarray. Candidate miRNAs with expression levels that were significantly altered in oral cancer samples or selected from a literature review were identified as Onco-miRNA or Tumor-suppressor miRNA. We found that miR-205-5p functions as a tumor suppressor in oral squamous cell carcinoma (OSCC), that miR-205-5p directly regulates TIMP-2 expression, and that miR-205-5p suppresses pro-MMP-2’s activation by regulating the TIMP-2 expression in OSCC cells. Thus, it may be possible to use miR-205-5p to regulate specific tumor-progressive genes as a novel therapeutic approach to treating OSCC.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] MicroRNA-205-5p suppresses the invasiveness of oral squamous cell carcinoma by inhibiting TIMP-2 expression.2018
Author(s)
Nagai H, Hasegawa S, Uchida F, Terabe T, Ishibashi Kanno N, Kato K, Yamagata K, Sakai S, Kawashiri S, Sato H, Yanagawa T, Bukawa H.
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Journal Title
International Journal of Oncology
Volume: 52
Pages: 841-850
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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