| Budget Amount *help |
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
In this study, we investigated the mechanism on invasion and metastasis of oral squamous cell caricinomas (OSCC).
EGFR status may affect the patient response to cetuximab treatment. The analysis of the immunomarker for EGFR, it was revealed that 58.3% of the total cases, and furthermore, that invasiveness was inversely correlated with EGFR expression. Loss of EGFR expression in OSCC was associated with epithelial mesenchymal transition (EMT).
OSCC is highly immunosuppressive, and PD-L1 expression has been proposed as a potential mechanism responsible for this phenotype. Thus, it is important to understand the mechanisms underlying regulation of PD-L1 expression in the OSCC microenvironment. PD-L1 expression in high-grade invasive OSCC was lower than that in a low-grade invasive OSCC and found a close correlation between PD-L1 expression and the EMT. PD-L1 expression was upregulated in macrophages and dendritic cells in high grade invasive human OSCC tissues or co-cultured.
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