| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Outline of Final Research Achievements |
In this study, we aim to develop a novel diagnostic and therapeutic method targeting cancer stem cells in human oral squamous cell carcinoma (OSCC), and developed a specific carbohydrate structure expressed on the cell surface of undifferentiated pluripotent stem cells We analyzed the cell and molecular biological characteristics of rBC2 LCN-recognizing carbohydrate positive cell group isolated from human oral squamous-cell carcinoma-derived cell line using rBC2LCN which recognizes lectin. Furthermore, we clarified a niche mechanism controlling self-renewal ability and differentiation ability, clarify its cell / molecular biological characteristics through identification of cytokine network molecule / signal group necessary for maintaining niche function, We aim to establish diagnostic and therapeutic methods for new cancer targeting stem cells.
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