Devlopment of novel oral cancer treatment with non-coding RNA by targetting metastatic organ and cancer stem cells.
| Project/Area Number |
15H05045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浜田 倫史 鹿児島大学, 医歯学域附属病院, 講師 (00444894)
熊丸 渉 九州大学, 大学病院, 講師 (90432947)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | 口腔癌 / microRNA / 血清マーカー / 癌幹細胞 / 上皮間葉移行 / BRACHYURY / SOX2 / 癌 / マイクロRNA / Brachyury / 機能性RNA / 腫瘍マーカー / 口腔癌幹細胞 |
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| Outline of Final Research Achievements |
Cancer cells produce short non-coding RNA and release to the body fluid. We discovered oral cancer specific microRNAs by comparing serum from normal and oral cancer indibiduals. These oral cancer specific microRNAs are the candidates for oral cancer biomarkers and we next analyzed quantitatively these microRNAs for each 40 normal and oral cancer serum samples. The oral cancer specific microRNA could diagnose oral cancer (sensitivity 67.5%) and normal individual (specificity 87.5%). This fact suggests the microRNA could be the serum marker for oral cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究結果より血清microRNAにより口腔癌が診断できることが明らかとなった。口腔癌には腫瘍マーカーがなく、がん検診のような多数の住民を対象とした場合の第一段検査が無かったが、血液検査陽性個人にのみ第2段の精密検査を行うことを可能とする技術となる。さらに、口腔癌を治療した後の再発や転移についても血液検査により検出が可能である。口腔癌特異的microRNAは遺伝子発現を阻害する機能を持つため、将来的に治療に応用することも可能と考えられる。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Expression levels of SOX2, KLF4 and brachyury transcription factors are associated with metastasis and poor prognosis in oral squamous cell carcinoma2016
Author(s)
Yoshihama R, Yamaguchi K, Imajyo I, Mine M, Hiyake N, Akimoto N, Kobayashi Y, Chigita S, Kumamaru W, Kiyoshima T, Mori Y, Sugiura T
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Journal Title
Oncology letters
Volume: 11
Issue: 2
Pages: 1435-1446
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas2016
Author(s)
Yokoyama, S. Higashi, M. Kitamoto, S. Oeldorf, M. Knippschild, U. Kornmann, M. Maemura, K. Kurahara, H. Wiest, E. Hamada, T. Kitazono, I. Goto, Y. Tasaki, T. Hiraki, T. Hatanaka, K. Mataki, Y. Taguchi, H. Hashimoto, S. Batra, S. K. Tanimoto, A. Yonezawa, S. Hollingsworth, M. A.
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Journal Title
Oncotarget
Volume: -
Issue: 27
Pages: 42553-42565
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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