| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
From the result of this study, we revealed the optimal conditions for effective and efficient supplemental vibration for accelerating tooth movement. Optimum-magnitude high-frequency vibration applied with static continuous force does not affect root resorption and induces NF-κB activation in osteoclasts, osteoblasts and osteocytes and increases periodontal ligament volume via osteoclastic bone resorption and promotes bone resorption in deep alveolar bone during tooth movement. These findings contribute to a better understanding of the mechanism by which optimum-magnitude high-frequency vibration accelerates tooth movement, and may lead to novel approaches for the safe and effective treatment of malocclusion.
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