Investigation into etiology and pathology of eating disorder caused by neurotransmitter disorders and its treatment strategy
| Project/Area Number |
15H05050
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
YOSHIDA Noriaki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (40230750)
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| Co-Investigator(Kenkyū-buntansha) |
古賀 義之 長崎大学, 病院(歯学系), 講師 (50175329)
藤下 あゆみ 長崎大学, 病院(歯学系), 医員 (30755723)
吉見 知子 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (20805973)
井上 富雄 昭和大学, 歯学部, 教授 (70184760)
中村 文 長崎大学, 病院(歯学系), 医員 (50711959)
内海 大 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (80622604)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOU Kousei 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00332726)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 咀嚼 / 摂食障害 / 神経伝達物質 / 顎運動 / 筋活動 / 筋電図 / ６自由度 / 嚥下 / 舌運動 / 顎口腔機能解析 / 摂食機能 / 顎口腔機能 |
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| Outline of Final Research Achievements |
The control mechanism of oral motor behavior associated with implication of neurotransmitters during mastication was invesitigated.When bicuculline - GABAA receptor antagonist was administrated,jaw movement paremeters such as gape size, lateral excursion and late-closing excursion during the occlusal phase were increased. Activities of the masseter and digastric muscles were enhanced. On the other hand, When muscimol - GABAA receptor agonist was administrated,all the jaw movement paremeters were decreased, and activities of the masseter and digastric muscles were also decreased. In the present study, It was suggested that The ordinary control mechanism of neurotransmitter plays an important role in regulating the motor coordination between opening and closing and muscles.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Distinctive features of Phox2b-expressing neurons in the reticular formation dorsal to the trigeminal motor nucleus.2017
Author(s)
Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Satoh F, Kawakami H, Takahashi K, Inoue T.
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Journal Title
Neuroscience
Volume: 358
Pages: 211-226
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice.2016
Author(s)
Ikawa Y, Mochizuki A, Katayama K, Kato T, Ikeda M, Abe Y, Nakamura S, Nakayama K, Wakabayashi N, Baba K, Inoue T
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Journal Title
Neurosci Res.
Volume: 113
Pages: 48-55
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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