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Investigation into etiology and pathology of eating disorder caused by neurotransmitter disorders and its treatment strategy

Research Project

Project/Area Number 15H05050
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

YOSHIDA Noriaki  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (40230750)

Co-Investigator(Kenkyū-buntansha) 古賀 義之  長崎大学, 病院(歯学系), 講師 (50175329)
藤下 あゆみ  長崎大学, 病院(歯学系), 医員 (30755723)
吉見 知子  長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (20805973)
井上 富雄  昭和大学, 歯学部, 教授 (70184760)
中村 文  長崎大学, 病院(歯学系), 医員 (50711959)
内海 大  長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (80622604)
Co-Investigator(Renkei-kenkyūsha) ITOU Kousei  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00332726)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords咀嚼 / 摂食障害 / 神経伝達物質 / 顎運動 / 筋活動 / 筋電図 / 6自由度 / 嚥下 / 舌運動 / 顎口腔機能解析 / 摂食機能 / 顎口腔機能
Outline of Final Research Achievements

The control mechanism of oral motor behavior associated with implication of neurotransmitters during mastication was invesitigated.When bicuculline - GABAA receptor antagonist was administrated,jaw movement paremeters such as gape size, lateral excursion and late-closing excursion during the occlusal phase were increased. Activities of the masseter and digastric muscles were enhanced. On the other hand, When muscimol - GABAA receptor agonist was administrated,all the jaw movement paremeters were decreased, and activities of the masseter and digastric muscles were also decreased. In the present study, It was suggested that The ordinary control mechanism of neurotransmitter plays an important role in regulating the motor coordination between opening and closing and muscles.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (27 results)

All 2018 2017 2016 2015

All Journal Article (15 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 15 results,  Open Access: 10 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Confocal calcium imaging analysis of respiratory-related burst activity in the parafacial region.2018

    • Author(s)
      Onimaru H, Nakamura S, Ikeda K, Kawakami K, Inoue T.
    • Journal Title

      Brain Res Bull.

      Volume: 139 Pages: 16-20

    • DOI

      10.1016/j.brainresbull.2018.01.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats2018

    • Author(s)
      Ino-Kondo Airi、Hotokezaka Hitoshi、Kondo Takanobu、Arizono Keira、Hashimoto Megumi、Hotokezaka Yuka、Kurohama Takeshi、Morita Yukiko、Yoshida Noriaki
    • Journal Title

      The Angle Orthodontist

      Volume: - Issue: 4 Pages: 474-482

    • DOI

      10.2319/112017-801.1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism of motor coordination of masseter and temporalis muscles for increased masticatory efficiency in mice2017

    • Author(s)
      Yoshimi T.、Koga Y.、Nakamura A.、Fujishita A.、Kohara H.、Moriuchi E.、Yoshimi K.、Tsai C.Y.、Yoshida N.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 44 Issue: 5 Pages: 363-374

    • DOI

      10.1111/joor.12491

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus2017

    • Author(s)
      Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Satoh F, Kawakami H, Takahashi K, Inoue T.
    • Journal Title

      Neuroscience

      Volume: 358 Pages: 211-226

    • DOI

      10.1016/j.neuroscience.2017.06.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Numeric simulation model for long-term orthodontic tooth movement with contact boundary conditions using the finite element method2017

    • Author(s)
      Hamanaka Ryo、Yamaoka Satoshi、Anh Tuan Nguyen、Tominaga Jun-ya、Koga Yoshiyuki、Yoshida Noriaki
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics

      Volume: 152 Issue: 5 Pages: 601-612

    • DOI

      10.1016/j.ajodo.2017.03.021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats2016

    • Author(s)
      Kurohama T, Hotokezaka H, Hashimoto M, Tajima T, Arita K, Kondo T, Ino A, Yoshida N
    • Journal Title

      Eur J Orthod

      Volume: 38 Issue: 4 Pages: 563-569

    • DOI

      10.2319/110416-794.1

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats2016

    • Author(s)
      Kurohama T, Hotokezaka H, Hashimoto M, Tajima T, Arita K, Kondo T, Ino A, Yoshida N
    • Journal Title

      Eur J Orthod

      Volume: 38 Pages: 277-286

    • DOI

      10.1093/ejo/cjw038

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of diabetes on tooth movement and root resorption after orthodontic force application in rats.2016

    • Author(s)
      Arita K, Hotokezaka H, Hashimoto M, Nakano-Tajima T, Kurohama T, Kondo T, Darendeliler MA, Yoshida N.
    • Journal Title

      Orthodontics and Craniofacial Research

      Volume: 19 Issue: 2 Pages: 83-92

    • DOI

      10.1111/ocr.12117

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Coordinated Respiratory Motor Activity in Nerves Innervating the Upper Airway Muscles in Rats2016

    • Author(s)
      Tachikawa S, Nakayama K, Nakamura S, Mochizuki A, Iijima T, Inoue T
    • Journal Title

      PLoS One

      Volume: 11 Issue: 11 Pages: e0166436-e0166436

    • DOI

      10.1371/journal.pone.0166436

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Postnatal changes in glutamatergic inputs of jaw-closing motoneuron dendrites2016

    • Author(s)
      Nagata S, Nakamura S, Nakayama K, Mochizuki A, Yamamoto M, Inoue T
    • Journal Title

      Brain Res Bull

      Volume: 127 Pages: 47-55

    • DOI

      10.1016/j.brainresbull.2016.08.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice2016

    • Author(s)
      Ikawa Y, Mochizuki A, Katayama K, Kato T, Ikeda M, Abe Y, Nakamura S, Nakayama K, Wakabayashi N, Baba K, Inoue T
    • Journal Title

      Neurosci Res

      Volume: 113 Pages: 48-55

    • DOI

      10.1016/j.neures.2016.07.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts.2016

    • Author(s)
      Shimada-Sugawara M, Sakai E, Okamoto K, Fukuda M, Izumi T, Yoshida N, Tsukuba T
    • Journal Title

      Sci Rep

      Volume: 印刷中 Issue: 6 Pages: 1321-1333

    • DOI

      10.1002/jcp.25235

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of feeding a soft diet and subsequent rehabilitation on the development of the masticatory function2015

    • Author(s)
      A. Fujishita, Y. Koga, D. Utsumi, A. Nakamura, T. Yoshimi, N. Yoshida
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 42 (4) Issue: 4 Pages: 266-274

    • DOI

      10.1111/joor.12248

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oral rehabilitation with orthognathic surgery after dental implant placement for class III malocclusion with skeletal asymmetry and posterior bite collapse2015

    • Author(s)
      Ohba S, Nakatani Y, Kawasaki T, Tajima N, Tobita T, Yoshida N, Sawase T, Asahina I
    • Journal Title

      Implant Dent

      Volume: 24 Pages: 487-90

    • DOI

      10.1097/id.0000000000000279

    • NAID

      120006986974

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dark/light transition and vigilance states modulate jaw-closing muscle activity level in mice.2015

    • Author(s)
      Katayama K, Mochizuki A, Kato T, Ikeda M, Nogawa Y, Nakamura S, Nakayama K, Wakabayashi N, Baba K, Inoue T.
    • Journal Title

      Neuroscience Research

      Volume: 101 Pages: 24-31

    • DOI

      10.1016/j.neures.2015.07.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Coordination of masticatory muscles and jaw movement in six-degrees of freedom depending on food texture during mastication2018

    • Author(s)
      Yoshimi T, Yasuda G, Moriuchi E, Fujishita A, Kohara H, Hamanaka R, Koga Y, Yoshida Y
    • Organizer
      The 11th Asian Pacific Orthodontic Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Postnatal change of glutamatergic synaptic transmission in the jaw-closing and jaw-opening motoneurons.2018

    • Author(s)
      Shimono S, Teshima R, Nakamura S, Nakayama K, Mochizuki A, Ikeda M, Inoue T.
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] モーションキャプチャーを用いた6自由度顎運動計測システムの改良と測定精度2017

    • Author(s)
      安田豪、森内絵美、吉見知子、藤下あゆみ、小原悠、濱中僚、古賀義之、吉田教明
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The effects of Citalopram on the masseter muscle activity during non-REM sleep in mice.2017

    • Author(s)
      Mochizuki A, Ikawa Y, Kato T, Ikeda M, Nakamura S, Nakayama K, Baba K, Inoue T.
    • Organizer
      The 6th Annual International Institute for Integrative Sleep Medicine (IIIS) Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ラット三叉神経運動核の背側網様体に存在するPhox2b陽性ニューロンの電気生理学的および形態学的特性は Phox2b陰性ニューロンと異なる2017

    • Author(s)
      那小屋公太,中村史朗,中山希世美,望月文子,佐藤文彦,吉田 篤,井上 誠,井上富雄
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] モーションキャプチャーを応用した6自由度顎運動計測システムを用いた多点同時解析2016

    • Author(s)
      森内絵美,吉見知子,藤下あゆみ,中村文,小原悠,濱中僚,古賀義之,吉田教明
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティ徳島(徳島県徳島市)
    • Year and Date
      2016-11-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 咬筋運動ニューロンのシナプス入力のセロトニンによる調節2016

    • Author(s)
      永田愛、中山希世美、山口徹太郎、槇宏太郎、井上富雄
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティ徳島(徳島県徳島市)
    • Year and Date
      2016-11-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 三叉神経運動ニューロンへのグルタミン酸性シナプス伝達機構の生後変化2016

    • Author(s)
      中村史朗、望月文子、中山希世美、井上富雄
    • Organizer
      日本顎口腔機能学会第57回学術大会
    • Place of Presentation
      東北大学星陵オーディトリアム(宮城県仙台市)
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] モーションキャプチャーを用いた小動物6 自由度顎運動解析システムの開発2016

    • Author(s)
      森内 絵美,吉見 知子,藤下 あゆみ,中村 文,濱中 僚,古賀 義之,吉田 教明
    • Organizer
      日本顎口腔機能学会第56 回学術大会
    • Place of Presentation
      東洋大学川越キャンパス7号館(埼玉県川越市)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウスにおける閉口相での咬筋および側頭筋の協調運動のメカニズムについて2015

    • Author(s)
      吉見知子,森内絵美,藤下あゆみ,中村 文,内海 大,吉見圭子,古賀義之,蔡 吉陽,吉田教明
    • Organizer
      第74回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ(福岡県・福岡市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ハイスピードカメラと3DマイクロX線CTを用いた小動物6自由度顎運動解析システムの構築2015

    • Author(s)
      森内絵美,吉見知子,藤下あゆみ,中村 文,内海 大,古賀義之,吉田教明
    • Organizer
      第74回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ(福岡県・福岡市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ボツリヌストキシン注入後の咀嚼筋機能低下によるマウス咀嚼運動の変化2015

    • Author(s)
      吉見知子,森内絵美,藤下あゆみ,中村 文,内海 大,吉見圭子,古賀義之,蔡 吉陽,吉田教明
    • Organizer
      日本顎口腔機能学会第54回学術大会
    • Place of Presentation
      鹿児島大学(鹿児島県・鹿児島市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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