Pathophysiology of diebetes-associated periodontitis and establishment of novel diagnosis system of diabetes-associated periodontitis
| Project/Area Number |
15H05054
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAGATA Toshihiko 徳島大学, 大学院医歯薬学研究部(歯学系), 名誉教授 (10127847)
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| Co-Investigator(Kenkyū-buntansha) |
成石 浩司 徳島大学, 病院, 講師 (00346446)
吉田 賀弥 徳島大学, 大学院医歯薬学研究部(歯学系), 講師 (60363157)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 糖尿病関連歯周炎 / AGE / 歯肉線維芽細胞 / マクロファージ / 糖尿病性関連歯周炎 / 歯周病 / 糖尿病 |
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| Outline of Final Research Achievements |
By a cross-sectional study, statistical differences of several parameters in periodontitis patients with or without diabetes were examined. Both levels of casual blood sugar (BS) and Hemoglobin A1c (HbA1c) of patients with diabetes were significantly higher than in patients without diabetes. Whereas, there was no significant difference between periodontitis patients with and without diabetes in the skin AF levels. In oral condition, there were no statistical difference between periodontitis patients with and without diabetes in the periodontal conditions. GCF sIL-6R levels in periodontitis patients with PPD over than 6mm were higher significantly than in periodontitis patients without PPD over than 6mm.
In in vitro study, high glucose (HG) induced significantly Pg LPS induced IL-6 production in THP-1. Glucose increased significantly sIL-6R production in THP-1 macrophages in a dose dependent manner. Both IL-1 and IL-6/sIL-6R dramatically enhanced the MMP-1 production in HG condition.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Association between Periodontal Condition and Kidney Dysfunction in Japanese Adults: A Cross-Sectional Study2016
Author(s)
1.Naruishi K, Oishi K, Inagaki Y, Horibe M, Bando M, Ninomiya M, Kawahara K, Minakuchi J, Kawashima S, Shima K, Kido J, Nagata T.
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Journal Title
Clin Exp Dent Res.
Volume: 2
Issue: 3
Pages: 1-8
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] YKL-40 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes2015
Author(s)
Kido J, Bando Y, Bando M, Kajiura Y, Hiroshima Y, Inagaki Y, Murata H, Ikuta T, Kido R, Naruishi K, Funaki M, Nagata T.
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Journal Title
Oral Diseases
Volume: 21
Issue: 5
Pages: 667-673
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Advanced Glycation End-Products Increase Calprotectin in Human Gingival Epithelial Cells2017
Author(s)
1.Hiroshima Y, Sakamoto E, Abe K, Yoshida K, Naruishi K, Nagata T, Shinohara Y, Geczy CL, Kido J
Organizer
95th International Association for Dental Research, General Session & Exhibition
Place of Presentation
San Francisco, USA
Year and Date
2017-03-22
Related Report
Int'l Joint Research
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