| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
By a cross-sectional study, statistical differences of several parameters in periodontitis patients with or without diabetes were examined. Both levels of casual blood sugar (BS) and Hemoglobin A1c (HbA1c) of patients with diabetes were significantly higher than in patients without diabetes. Whereas, there was no significant difference between periodontitis patients with and without diabetes in the skin AF levels. In oral condition, there were no statistical difference between periodontitis patients with and without diabetes in the periodontal conditions. GCF sIL-6R levels in periodontitis patients with PPD over than 6mm were higher significantly than in periodontitis patients without PPD over than 6mm.
In in vitro study, high glucose (HG) induced significantly Pg LPS induced IL-6 production in THP-1. Glucose increased significantly sIL-6R production in THP-1 macrophages in a dose dependent manner. Both IL-1 and IL-6/sIL-6R dramatically enhanced the MMP-1 production in HG condition.
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