| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
We hypothesized that gene polymorphisms such as beta-3 adrenergic receptor, PRR gamma and VDR TaqI might have gene-environmental and gene-gene interactions in periodontal disease. These studies were conducted by 1055 participants aged 55-79 years old. These results showed that chronic kidney disease (CKD) and periodontal disease can have reciprocal effect. In addition, beta-3 adrenergic receptor and PPAR gamma gene polymorphism were not independent risk factor for periodontal disease. However, the interaction between beta-3 adrenergic receptor and PPAR gamma gene poly morphism was associated significantly with periodontal disease in obese elderly females. There might be a correlation between the VDR TaqI genotype and CKD when severe levels of periodontal disease are present, Our studies suggest that there might be a gene-gene or gene-environmental interaction among periodontal disease and each gene polymorphism.
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