• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

International research project on physical growth and long-term prognosis in Twins and multiple births

Research Project

Project/Area Number 15H05105
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Community health nursing
Research InstitutionOsaka City University

Principal Investigator

Yokoyama Yoshie  大阪市立大学, 大学院看護学研究科, 教授 (50197688)

Co-Investigator(Kenkyū-buntansha) 福田 早苗  関西福祉科学大学, 健康福祉学部, 教授 (50423885)
大木 秀一  石川県立看護大学, 看護学部, 教授 (00303404)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords多胎児 / 双子 / 発育 / 出生体重 / BMI / 身長 / 学歴 / 双生児研究 / 発達 / 出生身長 / ponderal index / CODATwins project / 遺伝 / 環境 / 体格 / 三つ子 / 国際共同研究 / 体重
Outline of Final Research Achievements

Genetic and environmental variations of birth size were estimated using genetic structural equation modeling. The variance of birth weight and length was predominantly explained by shared environmental factors, whereas genetic variance contributing to birth size was small. Related to environmental factors, parental education showed a generally positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. We also analyzed the association between birthweight and BMI from infancy to adulthood within twin pairs. At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P<0.001).

Academic Significance and Societal Importance of the Research Achievements

本研究では,多胎児の発育過程の特徴を国際共同研究から明らかにすることを目的とした。出生時の体格は,遺伝と環境双方の影響を受けており,双生児研究法を用いた分析では,出生体重や出生身長の遺伝要因による影響は小さく,大部分が環境要因(母胎)の影響を受けていることが判明した。環境要因の1つとして,親の学歴が子どもの身長の発育に影響していることも明らかとなった。このような出生時の体格は、幼少期から思春期以降のBMIにも影響し,出生体重が1kg増加すれば,BMIが0.9 kg/m2増加することも示された。これらの結果から,妊娠期からの母胎環境は子どもの思春期以降の体格にも影響する重要な要因であると言える。

Report

(6 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (54 results)

All 2020 2018 2017 2016 2015 Other

All Int'l Joint Research (29 results) Journal Article (18 results) (of which Int'l Joint Research: 17 results,  Peer Reviewed: 18 results,  Open Access: 18 results,  Acknowledgement Compliant: 6 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Remarks (5 results)

  • [Int'l Joint Research] The University of Melbourne/The University of Queensland(オーストラリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Helsinki/University of Eastern Finland/Institute for Molecular Medicine Finland(フィンランド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] King's College/Keele University(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of California/University of Southern California/Wayne State University(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Seoul National University/Hallym University(韓国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Helsinki/University of Eastern Finland/Institute for Molecular Medicine(フィンランド)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of the Basque Country(スペイン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Colorado State University/University of Minnesota/University of Colorado(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] The University of Melbourne/Murdoch Childrens Research Institute(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University College London/Institute of Psychiatry(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Helsinki/University of Eastern Finland/Institute for Molecular Medicine Finland(フィンランド)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] The University of Melbourne/The University of Sydney/Murdoch Childrens Research Institute(オーストラリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Southern Denmark/University of Copenhagen/Odense University Hospital(デンマーク)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Vrije Universiteit(オランダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Boston University/University of California/Duke University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] niversity of Helsinki/Institute for Molecular Medicine(Finland)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Melbourne/Murdoch Childrens Research Institute/University of Melbourne(Australia)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Karolinska Institutet/Lund University(Sweden)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Boston University/Colorado State University/Duke University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University College London/University of Bristol/King's College London(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Helsinki/THL/Institute for Molecular Medicine FIMM(Finland)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] The University of Melbourne/Berghofer Medical Research Institute/Murdoch Childrens Research Institute(Australia)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Copenhagen/Odense University Hospital/Institute of Preventive Medicine(Denmark)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Boston University/Colorado State University/University of Washington(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University College London/University of Bristol/King's College London(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts2020

    • Author(s)
      Silventoinen K, Jelenkovic A, Sund R, Latvala A, 他75番目 Yokoyama Y, Boomsma DI, Kaprio J, et al.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 12681-12681

    • DOI

      10.1038/s41598-020-69526-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education2020

    • Author(s)
      Jelenkovic A, Sund R, Yokoyama Y, Latvala A, Sugawara M, et al.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 7974-7974

    • DOI

      10.1038/s41598-020-64883-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts2018

    • Author(s)
      Yokoyama Y, Jelenkovic A, Hur YM, Sund R, Fagnani C, et al.
    • Journal Title

      International Journal of Epidemiology

      Volume: 47 Issue: 4 Pages: 1195-1206

    • DOI

      10.1093/ije/dyy081

    • NAID

      120006716401

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019907

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between birth weight and educational attainment: an individual-based pooled analysis of nine twin cohorts2018

    • Author(s)
      Jelenkovic A, Mikkonen J, Martikainen P, Latvala A, Yokoyama Y, Sund R, Vuoksimaa E, et al.
    • Journal Title

      Journal of Epidemiology and Community Health

      Volume: 72(9) Issue: 9 Pages: 832-837

    • DOI

      10.1136/jech-2017-210403

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Triplets, birthweight, and handedness2018

    • Author(s)
      Heikkil&auml; K, Van Beijsterveldt CEM, Haukka J, Iivanainen M, Saari-Kemppainen A, Silventoinen K, Boomsma DI, Yokoyama Y, Vuoksimaa E
    • Journal Title

      Proceedings of the National Academy ofSciences of the United States of America

      Volume: 115(23) Issue: 23 Pages: 6076-6081

    • DOI

      10.1073/pnas.1719567115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts2018

    • Author(s)
      Jelenkovic A, Sund R, Yokoyama Y, Hur YM, Ullemar V, Almqvist C, Magnusson PK, Willemsen G,
    • Journal Title

      Scientific Reports

      Volume: 8(1) Issue: 1 Pages: 6300-6300

    • DOI

      10.1038/s41598-018-24634-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project2018

    • Author(s)
      Jelenkovic A, Yokoyama Y, Sund R, Hur YM, Harris JR, Brandt I, Nilsen TS, Ooki S, Ullemar V, et al.
    • Journal Title

      Early Human Development

      Volume: 120 Pages: 53-60

    • DOI

      10.1016/j.earlhumdev.2018.04.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts2017

    • Author(s)
      Silventoinen Karri、Jelenkovic Aline、et al.
    • Journal Title

      Twin Research and Human Genetics

      Volume: 20 Issue: 5 Pages: 395-405

    • DOI

      10.1017/thg.2017.49

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts2017

    • Author(s)
      Silventoinen Karri、Jelenkovic Aline、et al.
    • Journal Title

      The American Journal of Clinical Nutrition

      Volume: 106 Issue: 2 Pages: 457-466

    • DOI

      10.3945/ajcn.117.153643

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts2017

    • Author(s)
      ・Bogl LH, Jelenkovic A, Vuoksimaa E, Ahrenfeldt L, Pietil&auml;inen KH, et al.
    • Journal Title

      Biology of Sex Differences

      Volume: 8 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s13293-017-0134-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project2017

    • Author(s)
      Jelenkovic A, Yokoyama Y, Sund R, Pietil&auml;inen KH, Hur YM, Willemsen G, Bartels M, van Beijsterveldt TC, Ooki S, Saudino KJ, Stazi MA, Fagnani C, D'Ippolito C, Nelson TL, Whitfield KE, et al.
    • Journal Title

      Int J Epidemiol

      Volume: 19 Issue: 5 Pages: 1-11

    • DOI

      10.1093/ije/dyx031

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genetic and environmental influences on adult human height across birth cohorts from 1886 to 19942016

    • Author(s)
      Jelenkovic A, Hur YM, Sund R, Yokoyama Y, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Tan Q, Zhang D, Pang Z, Aaltonen S, Heikkil&auml; K, &Ouml;ncel SY, Aliev F, Rebato E, Tarnoki AD, Tarnoki DL, Christensen K, Skytthe A, Kyvik KO, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, et al.
    • Journal Title

      Elife

      Volume: 5 Pages: 1-14

    • DOI

      10.7554/elife.20320

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study2016

    • Author(s)
      Silventoinen K, Jelenkovic A, Sund R, Hur YM, Yokoyama Y, et al.
    • Journal Title

      Am J Clin Nutr

      Volume: 104(2) Issue: 2 Pages: 371-379

    • DOI

      10.3945/ajcn.116.130252

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts2016

    • Author(s)
      Jelenkovic A, Sund R, Hur YM, Yokoyama Y, Hjelmborg JV, M&ouml;ller S, et al.
    • Journal Title

      Scientific reports

      Volume: 6 Issue: 1 Pages: 1-12

    • DOI

      10.1038/srep28496

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Twin’s birth-order differences in height and body mass index from birth to old age: a pooled study of 26 twin cohorts participated in the CODATwins project2016

    • Author(s)
      Yokoyama Y, Jelenkovic A, Sund R, Sung J, Hopper J, et al.
    • Journal Title

      Twin research and human genetics

      Volume: 19(2) Issue: 2 Pages: 112-24

    • DOI

      10.1017/thg.2016.11

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 1.Child Maltreatment among singletons and multiple births in Japan: A population-based study2015

    • Author(s)
      Yokoyama Y, Oda T, Nagai N, Sugimoto M, and Mizukami K
    • Journal Title

      Twin research and human genetics

      Volume: 18 Issue: 6 Pages: 806-811

    • DOI

      10.1017/thg.2015.67

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.2015

    • Author(s)
      Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Chika Honda et al.
    • Journal Title

      Twin Research and Human Genetics

      Volume: 18 Issue: 5 Pages: 557-570

    • DOI

      10.1017/thg.2015.57

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits2015

    • Author(s)
      Karri Silventoinen, Aline Jelenkovic, Reijo Sund, et al.
    • Journal Title

      Twin Research and Human Genetics

      Volume: 18(4) Issue: 4 Pages: 348-360

    • DOI

      10.1017/thg.2015.29

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 双子の出生順位による出生後から高齢期における身長および体格への影響:CODA Twins プロジェクトにおける26のツインコホートスタディ2017

    • Author(s)
      Yokoyama Y, Jelenkovic A, Sund R, Sung J, Hopper J, Ooki S, Heikkil&auml; K, Aaltonen S, Tarnoki AD, Tarnoki DL, Willemsen G, Bartels M, van Beijsterveldt CEM, Saudino KJ, Nelson TL, Whitfield KE, Wardle J, Llewellyn CH, Fisher A, He M, Ding X, et al.
    • Organizer
      日本双生児学会学術集会
    • Place of Presentation
      埼玉、十文字学園女子大学
    • Year and Date
      2017-01-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] The West Japan Twins and Higher Order Multiple Birth Registry2015

    • Author(s)
      Yoshie Yokoyama
    • Organizer
      International Network of Twin Registries(INTR) Consortium Meeting
    • Place of Presentation
      Osaka University,  Osaka, Japan
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks]

    • URL

      http://www.nurs.osaka-cu.ac.jp/chiiki_kango/

    • Related Report
      2019 Annual Research Report
  • [Remarks] http://www.nurs.osaka-cu.ac.jp/chiiki_kango/

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      http://www.nurs.osaka-cu.ac.jp/chiiki_kango/

    • Related Report
      2017 Annual Research Report
  • [Remarks] http://www.nurs.osaka-cu.ac.jp/chiiki_kango/

    • Related Report
      2016 Annual Research Report
  • [Remarks] http://www.nurs.osaka-cu.ac.jp/chiiki_kango/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-11-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi