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Identification of hormonal active compounds found in coral reef seawater in Mauritius

Research Project

Project/Area Number 15H05269
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Natural medicines
Research InstitutionShizuoka University

Principal Investigator

Tokumoto Toshinobu  静岡大学, 理学部, 教授 (30273163)

Co-Investigator(Kenkyū-buntansha) 小谷 真也  静岡大学, 農学部, 准教授 (20510621)
鈴木 款  静岡大学, 創造科学技術大学院, 特任教授 (30252159)
CASARETO Beatriz  静岡大学, グリーン科学技術研究所, 教授 (60402244)
Research Collaborator Theeshan Bahorun  モーリシャス大学, CBBR 研究所, 教授
Ranjeet Bagooli  モーリシャス大学, 海洋生物学部, 准教授
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords天然資源 / ホルモン活性物質 / ステロイド膜受容体 / 天然ホルモン活性物質 / モーリシャス / サンゴ礁
Outline of Final Research Achievements

The aim of this study is isolation and determination of chemical structure of hormonal active compounds found in coral seawater. For that, we concentrated hormonal compounds in the seawaters from shallow coral reef on the cartridge. To isolate and characterize the compounds, HPLC and molecular mass analysis were conducted. The active compounds were detected in only summer time. Amount of active compounds in coral seawater was estimated as 10-100 ng/1000L. Molecular masses of active compounds determined as 447 and 621 Da by molecular mass analysis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Book (1 results)

  • [Int'l Joint Research] モーリシャス大学/CBBR研究所(モーリシャス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] CBBR/University of Mauritius(Mauritius)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] CBBR/University of Mauritius(Mauritius)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Detecting membrane progestin receptor (mPR)-interacting compounds from coral seawater in Mauritius.2017

    • Author(s)
      T. Tokumoto, S. Kodani, T. Miyazaki, Y. Suzuki, B. Casareto, T. Bahorun, R. Bhagooli
    • Journal Title

      Western Indian Ocean Journal of Marine Science

      Volume: 1 Pages: 77-84

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment of procedures for studying mPR-interacting agents and physiological roles of mPR2016

    • Author(s)
      Toshinobu Tokumoto, Md. Babul Hossain, Jun Wang
    • Journal Title

      Steroids

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Coral reefs stay on new frontiers of natural compounds.2018

    • Author(s)
      T. Tokumoto
    • Organizer
      State and conservation of our coral reefs
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identification of membrane progestin receptor (mPR) interacting compounds from coral seawater in Mauritius2016

    • Author(s)
      S. Kodani, T. Miyazaki, R. Bhagooli, T. Bahorun and T. Tokumoto
    • Organizer
      The University Research Week 2016
    • Place of Presentation
      University of Mauritius, Mauritius
    • Year and Date
      2016-09-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Membrane progestin receptor (mPR) a possible target for new drugs2015

    • Author(s)
      Toshinobu Tokumoto, MD Babul Hossain, Jun Wang, Takehiro Miyazaki
    • Organizer
      9th SFRR-Africa
    • Place of Presentation
      Hennessy Park Hotel, (Mauritius)
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ESTABLISHMENT OF PROCEDURES FOR mPR INTERACTING AGENTS AND STUDY ON PHYSIOLOGICAL ROLES OF mPR2015

    • Author(s)
      Toshinobu Tokumoto
    • Organizer
      9th Rapid Responses to Steroid Hormones
    • Place of Presentation
      Taipei TAIWAN
    • Year and Date
      2015-06-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] ナノバイオ・テクノロジー 「ステロイドホルモンの新しい作用のしくみ」2016

    • Author(s)
      徳元俊伸 他
    • Total Pages
      267
    • Publisher
      静岡学術出版
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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