| Project/Area Number |
15H05276
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 海外学術 |
|---|
| Research Field |
Parasitology (including sanitary zoology)
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
Tsuboi Takafumi 愛媛大学, プロテオサイエンスセンター, 教授 (00188616)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
高島 英造 愛媛大学, プロテオサイエンスセンター, 准教授 (50366762)
|
|---|
| Research Collaborator |
SATTABONGKOT Jetsumon マヒドン大学, 熱帯医学部, 教授
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
|---|
| Keywords | 原虫 / マラリア / サーベイランス / プロテインアレイ / タイ |
|---|
| Outline of Final Research Achievements |
We have recently identified and validated a panel of serological markers able to detect recent exposure to P. vivax infection, thereby indirectly identifying malaria hot-spots. We screened 307 P. vivax proteins for their ability to induce IgG responses in P. vivax-exposed individuals in Thailand, Brazil, and Papua New Guines determined the kinetic profile of these responses over 9-months in the absence of any recurrent infections. Candidate markers were down-selected based on high immunogenicity at the time of infection, comparable antibody longevity between the three sites and low levels of individual variation in IgG responses. Finally, 55 down-selected proteins are the sero-marker candidates for the malaria hot-spot surveillance.
|
