| Project/Area Number |
15H05291
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Yasuda Yoshinari 名古屋大学, 医学系研究科, 寄附講座准教授 (60432259)
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| Co-Investigator(Kenkyū-buntansha) |
丸山 彰一 名古屋大学, 医学系研究科, 教授 (10362253)
堀尾 勝 大阪大学, 医学系研究科, 准教授 (20273633)
石井 秀樹 名古屋大学, 医学部附属病院, 講師 (90456674)
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| Research Collaborator |
ISEKI kunitoshi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | 腎代替アウトカム指標 / GFR / 尿タンパク / IgA腎症 / GFR推算式 / 腎アウトカム指標 / 血清クレアチニン / 血清シスタチンC / GFR低下速度 / 内科 / 臨床 / 循環器・高血圧 / 血清クレアチニン値 / 血清シスタチンC値 / 尿蛋白 / 糖尿病 |
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| Outline of Final Research Achievements |
In Asian collaborative study, we analyzed suitable surrogate renal outcomes for clinical research. First, we established accurate renal function evaluation methods for Korean, Taiwan ,Thai and Indian CKD patients. Second, we analyzed utility of various renal outcomes in Asia. In health-check subject and CKD cohort studies, 30% decrease in eGFR could be surrogate renal outcome instead of hard end point including end stage kidney disease. Among IgA nephropathy patients, 50% increase in serum creatinine was good renal outcome to assess treatment effect and prognosis in renal biopsy. By surveillance of Asian renal outcome studies, GFR decline rate was sensitive and reliable renal outcome.
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| Academic Significance and Societal Importance of the Research Achievements |
アジア人種に適した腎機能評価法に基づく腎代替アウトカム指標を用いることで、腎領域における臨床研究が推進できると期待される。本研究を通じたアジア各国との国際共同体制は、日本を中心とした腎領域国際共同研究の基盤となる。
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