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Exploration of the role of environmental chemical (arsenic) in the development of diabetes and the related metabolic disorders for South Asian Countries

Research Project

Project/Area Number 15H05294
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Metabolomics
Research InstitutionUniversity of Tsukuba

Principal Investigator

Kawano Satoru  筑波大学, 医学医療系, 講師 (90323295)

Co-Investigator(Kenkyū-buntansha) 下條 信威  筑波大学, 医学医療系, 講師 (20462210)
Jesmin Subrina  筑波大学, 人間総合科学研究科, 研究員 (60374261)
岡崎 修  国立研究開発法人国立国際医療研究センター, 循環器内科, 医長 (30203970)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords南アジア / 糖尿病 / メタボリック症候群 / ヒ素 / メカニズム
Outline of Final Research Achievements

We conducted a cross sectional study (sample size=3351) in rural Bangladesh. We did in depth analysis of non-communicable disease (NCD) risk factors in this study. Diabetes mellitus (DM), the world greatest epidemic, is highly prevalent in arsenic affected population and is increasing over-time (1998: 4.4% vs. current study 13.2% in 2017) in Bangladesh. DM prevalence in arsenic areas is highly dependent on drinking water arsenic concentration. Numbers of arsenic cases were higher in the people whose drinking water has more than 50microgram/L arsenic concentration. DM prevalence in arsenic areas does not depend on the duration of arsenic exposure time or the presence of arsenic skin lesion. Among, 18.2% of the DM participants reported a family history of type 2 DM. Only 45.5% of the participants with T2DM were already diagnosed, with the remaining 54.5% being diagnosed on blood tests during the study.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (35 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (14 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 13 results,  Open Access: 12 results,  Acknowledgement Compliant: 3 results) Presentation (18 results) (of which Int'l Joint Research: 14 results,  Invited: 3 results)

  • [Int'l Joint Research] HDRCRP/ボグラ医科大学/Shuvo Diagnostic Center Dhunat(バングラデシュ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 農村地域住民のための健康と疾病研究センター/ボグラ医科大学/Shuvo Diagnostic Center Dhunat(バングラデシュ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] HDRCRP/Bogra Medical College/Shuvo Diagnostic Center Dhunat(Bangladesh)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Hyper-hippocampal glycogen induced by glycogen loading with exhaustive exercise2018

    • Author(s)
      Soya Mariko、Matsui Takashi、Shima Takeru、Jesmin Subrina、Omi Naomi、Soya Hideaki
    • Journal Title

      Scientific Reports

      Volume: - Issue: 1 Pages: 1285-1285

    • DOI

      10.1038/s41598-018-19445-4

    • NAID

      120007134504

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cerebral Tissue Oxygenation Index Using Near-infrared Spectroscopy during Extracorporeal Cardio-pulmonary Resuscitation Predicted Good Neurological Recovery in a Patient with Acute Severe Anemia2017

    • Author(s)
      Koyama Y, Mizutani T, Marushima A, Sonobe A, Shimojo N, Kawano S
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 18 Pages: 2451-2453

    • DOI

      10.2169/internalmedicine.7826-16

    • NAID

      130006078614

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of the Japanese version of the Preschool Confusion Assessment Method for the ICU.2017

    • Author(s)
      Matsuishi Y, Hoshino H, Shimojo N, Enomoto Y, Kido T, Jesmin S, Sumitani M, Inoue Y.
    • Journal Title

      Acute Med Surg.

      Volume: 15;5(1) Issue: 1 Pages: 102-105

    • DOI

      10.1002/ams2.306

    • NAID

      120007134140

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differences in coagulofibrinolytic changes between post-cardiac arrest syndrome of cardiac causes and hypoxic insults: a pilot study.2017

    • Author(s)
      Wada T, Gando S, Mizugaki A, Kodate A, Sadamoto Y, Murakami H, Maekawa K, Katabami K, Ono Y, Hayakawa M, Sawamura A, Jesmin S, Ieko M.
    • Journal Title

      Acute Med Surg.

      Volume: 27;4(3) Issue: 3 Pages: 371-372

    • DOI

      10.1002/ams2.270

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Daily exercise program can improve low HDL level in apparently healthy rural women in Bangladesh.2017

    • Author(s)
      Jesmin, S.; Rahman, M.A.; Islam, M.M.; Kawano, S.; Habib, A.K.M.A.
    • Journal Title

      Journal of Shaheed Ziaur Rahman Medical College

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] l Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes.2017

    • Author(s)
      Shima, T.; Matsui, T.; Jesmin, S.; Okamoto, M.; Soya, M.; Inoue, K.; Liu, Y.F.; Torres-Aleman, T.; McEwen, B.S.; Soya, H.
    • Journal Title

      Diabetologia

      Volume: 60(3) Pages: 597-606

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Warning message for arsenic-induced diabetes prevention in rural Bangladesh2017

    • Author(s)
      Jesmin S, Kawano S, Rahman A, Zaedi S, Habib, AKMA
    • Journal Title

      Published in sponsored with Bogra Medical College and HDRCRP

      Volume: - Pages: 1-3

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes.2017

    • Author(s)
      Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, Liu YF, Torres-Aleman I, McEwen BS and Soya H
    • Journal Title

      Diabetologia

      Volume: 60 Issue: 3 Pages: 597-606

    • DOI

      10.1007/s00125-016-4164-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] revalence of metabolic syndrome components among early age onset acute in coronary syndrome patients in Bangladesh.2016

    • Author(s)
      Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Shimojo N, Sultana SN, Sohael F, Okazaki O, Moroi M, Kawano S.
    • Journal Title

      Endocrine Practice

      Volume: 別冊 Pages: 121-121

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] National burden on non-communicable disease risk factors in Bangladesh.2016

    • Author(s)
      Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Sohael F, Shimojo N, Okazaki O, Kawano S.
    • Journal Title

      Endocrine Practice

      Volume: 別冊 Pages: 182-182

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gestational diabetes mellitus (GDM) in Bangladesh.2016

    • Author(s)
      Mamun AA, Jesmin S, Rahman MA, Islam MM, Sohael F, Sultana SN, Yamaguchi N, Okazaki O, Kawano S.
    • Journal Title

      Endocrine Practice

      Volume: 別冊 Pages: 233-233

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Differential effects of type 2 diabetes on brain glycometabolism in rats: focus on glycogen and monocarboxylate transporter 22016

    • Author(s)
      Shima T, Jesmin S, Matsui T, Soya M, Soya H
    • Journal Title

      The Journal of Physiological Sciences

      Volume: - Issue: 1 Pages: 1-7

    • DOI

      10.1007/s12576-016-0508-6

    • NAID

      40021443633

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh.2015

    • Author(s)
      S. Jesmin, Y. Iwashima, M.A. Rahman, A.K.M.A. Habib, N. Shimojo, M. Moroi, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Kawano.
    • Journal Title

      European Heart Journal

      Volume: 36(1) Pages: 897-897

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nationwide Non-Communicable Disease Risk Factors Profile in Bangladesh.2015

    • Author(s)
      S. Jesmin, M.A. Rahman, A.K.M.A. Habib, M.M. Islam, S.N. Sultana, S. Zaedi, T. Khatun, F. Sohael, N. Yamaguchi, O. Okazaki, Y. Iwashima, S. Kawano.
    • Journal Title

      Journal of Hypertension

      Volume: 33 Issue: Supplement 2 Pages: 2-2

    • DOI

      10.1097/01.hjh.0000469776.89393.2e

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Prevention of type 2 diabetes mellitus-induced hippocampal cognitive dysfunction from pre-diabetic stage through a 4 months mild exercise regimen.2018

    • Author(s)
      Jesmin, S.; Shima, T.; Takahashi, K.; Omura, K.; Khatun, A.; Matsuishi, Y.; Koizumi, H.; Soya, M1.; Sato, R.; Jangsoo, Y.; Kasane, O.; Matsui, T.; Iwashima, Y.; Yamaguchi, N.; Kawano, S.; Shimojo, N.; Soya, H.
    • Organizer
      2nd General Meeting on Creation and Promotion of WILLDYNAMICS
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevention of type 2 diabetes mellitus-induced hippocampal cognitive dysfunction from pre-diabetic stage through a 4 months mild exercise regimen.2018

    • Author(s)
      Jesmin, S.; Shima, T.; Takahashi, K.; Omura, K.; Khatun, A.; Matsuishi, Y.; Koizumi, H.; Soya, M1.; Sato, R.; Jangsoo, Y.; Kasane, O.; Matsui, T.; Iwashima, Y.; Yamaguchi, N.; Kawano, S.; Shimojo, N.; Soya, H.
    • Organizer
      International ARIHHP Forum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 発症前期からの4か月に渡る低強度運動トレーニングは2型糖尿病に伴う海馬機能低下を予防するか?2018

    • Author(s)
      荒井サブリナ、島孟留、高橋佳那子、大村航希、アデュリ・ハトゥン、松石雄二郎、小泉光、征矢茉莉子、佐藤崚太、陸暲洙、小倉かさね、松井崇、岩嶋義雄、山口直人、河野了、下條信威、征矢英昭
    • Organizer
      2nd ARIHHP Science week Forum
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Six weeks moderate exercise is effective in ameliorating spatial memory impairment in estrogen-depleted female rat2017

    • Author(s)
      Jesmin, S.; Takahashi, K.; Shima, T.; Matsuishi, Y.; Soya, M.; Yook, J.S.; Ogura, K.; Shimojo, N.; Kawano, S.; Iwashima, Y.; Yamaguchi, N.; Soya, H.
    • Organizer
      International ARIHHP Forum Science week
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A relatively longer duration of exercise regimen from pre-diabetes prevents spatial memory impairment with improvement of diabetic symptoms in a type 2 diabetic rat model2017

    • Author(s)
      Jesmin, S.; Shima, T.; Takahashi, K.; Matsuishi, Y.; Soya, M.; Yook, J.S.; Koizumi, H.; Soto, R.; Ogura, K.; Shomojo, N.; Kawano, S.; Iwashima, Y.; Yamaguchi, N.; Soya, H.
    • Organizer
      Global Initiative for Sports Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exercise from pre-diabetes prevents cognitive impairment with improvement of diabetic symptoms in a type 2 diabetic rat model2017

    • Author(s)
      Jesmin, S.; Shima, T.; Takahashi, K.; Omura, K.; Khatun, A.; Matsuishi, Y.; Koizumi, H.; Soya, M.;Sato, R.; Jangsoo, Y.; Kasane, O.; Matsui, T.; Iwashima, Y.; Yamaguchi, N.; Kawano, S.; Shimojo, N.; Soya, H.
    • Organizer
      Annual meeting of Japanese Society of Physical Fitness and Sports Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] Six weeks moderate exercise is effective in ameliorating spatial memory impairment in estrogen-depleted female rat2017

    • Author(s)
      Jesmin S, Shima T, Takahashi K, Omura K, Khatun A, Matsuishi Y, Koizumi H, Soya M, Sato R, Jangsoo Y, Kasane O, Matsui T, Iwashima Y, Yamaguchi N, Soya H
    • Organizer
      International ARIHHP Forum Science week
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Are we ready to prevent arsenic-induced diabetes in rural Bangladesh?2017

    • Author(s)
      Subrina Jesmin, Saturo Kawano
    • Organizer
      Specially arranged symposium at Bogra Medical college
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Age-independent mediation of arsenic in diabetes development in rural Bangladesh2017

    • Author(s)
      Subrina Jesmin, Saturo Kawano
    • Organizer
      Specially arranged symposium at HDRCRP
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Effects of endothelin receptor antagonism on VEGF signaling in diabetic penis: A possible clinical implication for diabetes erectile dysfunction.2016

    • Author(s)
      Mamun AA, Jesmin S, Rahman MA, Islam MM, Shimojo N, Sultana SN, Okazaki O, Kawano S.
    • Organizer
      The 25th AACE Annual Scientific & Clinical Congress
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diabetes induced cardiac VEGF system in estrogen/estrogen receptor manipulated animal model.2016

    • Author(s)
      Mamun AA, Jesmin S, Rahman MA, Islam MM, Shimojo N, Sultana SN, Yamaguchi N, Okazaki O, Kawano S.
    • Organizer
      The 25th AACE Annual Scientific & Clinical Congress
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence of metabolic syndrome components among early age onset acute in coronary syndrome patients in Bangladesh.2016

    • Author(s)
      Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Shimojo N, Sultana SN, Sohael F, Okazaki O, Moroi M, Kawano S.
    • Organizer
      The 25th AACE Annual Scientific & Clinical Congress
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] National burden on non-communicable disease risk factors in Bangladesh.2016

    • Author(s)
      Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Sohael F, Shimojo N, Okazaki O, Kawano S.
    • Organizer
      The 25th AACE Annual Scientific & Clinical Congress
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gestational diabetes mellitus (GDM) in Bangladesh.2016

    • Author(s)
      Mamun AA, Jesmin S, Rahman MA, Islam MM, Sohael F, Sultana SN, Yamaguchi N, Okazaki O, Kawano S.
    • Organizer
      The 25th AACE Annual Scientific & Clinical Congress
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh2015

    • Author(s)
      S. Jesmin, Y. Iwashima, M.A. Rahman, A.K.M.A. Habib, N. Shimojo, M. Moroi, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Kawano.
    • Organizer
      ESC Congress 2015
    • Place of Presentation
      London ( United Kingdom)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nationwide Assessment of Hypertension Among the Adult Population in Bangladesh2015

    • Author(s)
      M.A. Rahman, S. Jesmin, M.M. Islam, S. Zaedi, A.S.H. Hasan, A.K.M.A. Habib, T. Khatun, S.N. Sultana, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Iwashima. A
    • Organizer
      11th Asia Pacific Congress of Hypertension (APCH 2015)
    • Place of Presentation
      Bali (Indonesia)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nationwide Non-Communicable Disease Risk Factors Profile in Bangladesh2015

    • Author(s)
      M.A. Rahman, S. Jesmin, A.K.M.A. Habib, M.M. Islam, S.N. Sultana, S. Zaedi, T. Khatun, F. Sohael, N. Yamaguchi, O. Okazaki, Y. Iwashima, S. Kawano.
    • Organizer
      11th Asia Pacific Congress of Hypertension (APCH 2015)
    • Place of Presentation
      Bali (Indonesia)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence of Metabolic syndrome and its components among rural Bangladeshi women2015

    • Author(s)
      M.A. Rahman, S. Jesmin, A.A. Mamun, M.M. Islam, T. Khatun, S.N. Sultana, F. Sohael, S.N. Sultana, A.K.M.A. Habib
    • Organizer
      The 2nd SAFES (South Asian Federation of Endocrine Societies) Summit
    • Place of Presentation
      Dhaka (Bangladesh)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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