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Monitoring possible emergence of H5N1 influenza variants with higher pandemic potential in Egypt

Research Project

Project/Area Number 15H05295
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Infectious disease medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Watanabe Yohei  京都府立医科大学, 医学(系)研究科(研究院), 講師 (50452462)

Co-Investigator(Kenkyū-buntansha) 鈴木 康夫  中部大学, 生命健康科学部, 客員教授 (00046278)
高橋 和郎  国際医療福祉大学, 大学病院, 教授 (10171472)
中屋 隆明  京都府立医科大学, 医学(系)研究科(研究院), 教授 (80271633)
大道寺 智  京都府立医科大学, 医学(系)研究科(研究院), 講師 (80432433)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsウイルス学 / 感染症内科学 / インフルエンザウイルス / 国際感染症
Outline of Final Research Achievements

Egypt has had the highest numbers of human infection cases of H5N1 influenza viruses. In this study, we performed comprehensive surveillance for avian influenza in Egypt and also investigated evolution dynamics of the viruses disseminating in the country.
The results showed that not only the H5N1 viruses but also H9N2 viruses has now prevailed in Egypt with multiple human infection cases. Both viruses has accumulated mutations conferring an expanded host range including mammals. The two viruses also had high genetic compatibility, which may allow a reassortment event to create novel genotypic influenza viruses with pandemic potential.

Academic Significance and Societal Importance of the Research Achievements

鳥インフルエンザウイルスのヒト感染事例が際立って多い国の1つであるエジプトにおいて先駆的にウイルスの蔓延状況と進化動態を調査することで、現在までに様々な宿主適応変異を蓄積していることが明らかとなり、現地での継続的なモニタリングの必要性が明らかとなった。
本研究で明らかとなったウイルスの進化動態や宿主適応性に関する情報は、学会発表や論文を通じて世界にアラートしており、エジプトにおけるパンデミックのリスク評価において極めて有益な情報を提起したと考えられる。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (88 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (9 results) Journal Article (33 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 32 results,  Open Access: 21 results,  Acknowledgement Compliant: 5 results) Presentation (40 results) (of which Int'l Joint Research: 13 results,  Invited: 8 results) Book (1 results) Remarks (5 results)

  • [Int'l Joint Research] Alexandria University/Damanhour University(エジプト)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 長崎大学熱帯医学研究所ベトナム拠点/ベトナム国立衛生疫学研究所(ベトナム)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Alexandria University/Damanhour University(エジプト)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Thammasat University(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ベトナム国立衛生疫学研究所/長崎大学熱帯医学研究所ベトナム拠点(ベトナム)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Alexandria University/Damanhour University(エジプト)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Thammasat University(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Alexandria University/Damanhour University(エジプト)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Alexandria University/Damanhour University(エジプト)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Preparation and Detection of Glycan-Binding Activity of Influenza Virus2020

    • Author(s)
      Nakakita Shin-Ichi , Sriwilaijaroen Nongluk , Suzuki Yasuo , Hirabayashi Jun
    • Journal Title

      Methods in Molecular Biology

      Volume: 2132 Pages: 567-583

    • DOI

      10.1007/978-1-0716-0430-4_49

    • ISBN
      9781071604298, 9781071604304
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hemagglutinin Inhibitors Are Potential Future Anti-Influenza Drugs for Mono- And Combination Therapies2020

    • Author(s)
      Sriwilaijaroen Nongluk , Suzuki Yasuo
    • Journal Title

      Methods in Molecular Biology

      Volume: 2132 Pages: 547-565

    • DOI

      10.1007/978-1-0716-0430-4_48

    • ISBN
      9781071604298, 9781071604304
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] H3N2 Avian Influenza Viruses Detected in Live Poultry Markets in China Bind to Human-Type Receptors and Transmit in Guinea Pigs and Ferrets2020

    • Author(s)
      Guan Lizheng , Shi Jianzhong , Kong Xingtian , Ma Shujie , Zhang Yaping , Yin Xin , He Xijun , Liu Liling , Suzuki Yasuo , Li Chengjun , Deng Guohua , Chen Hualan
    • Journal Title

      Emerging Microbes & Infections

      Volume: 8 Issue: 1 Pages: 1280-1290

    • DOI

      10.1080/22221751.2019.1660590

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of Myxovirus resistance protein in birds showing different susceptibilities to highly pathogenic influenza virus2020

    • Author(s)
      Hagiwara Katsuro , Nakaya Takaaki , Onuma Manabu
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 82 Issue: 5 Pages: 619-625

    • DOI

      10.1292/jvms.19-0408

    • NAID

      130007844431

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Avian Influenza Virus Detection by Optimized Peptide Termination on a Boron-Doped Diamond Electrode2020

    • Author(s)
      Matsubara Teruhiko , Ujie Michiko , Yamamoto Takashi , Einaga Yasuaki , Daidoji Tomo , Nakaya Takaaki , Sato Toshinori
    • Journal Title

      ACS sensors

      Volume: 5 Issue: 2 Pages: 413-439

    • DOI

      10.1021/acssensors.9b02126

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of a Recombinant Avian Avulavirus Serotype 10 Vectored Vaccine by the Addition of Untranslated Regions2020

    • Author(s)
      Tsunekuni Ryota , Tanikawa Taichiro , Nakaya Takaaki , Saito Takehiko
    • Journal Title

      Vaccine

      Volume: 38 Issue: 4 Pages: 822-829

    • DOI

      10.1016/j.vaccine.2019.10.098

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals.2019

    • Author(s)
      Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Takagi T, Nakaya T, Matsumoto K, Watanabe Y.
    • Journal Title

      PLOS Pathogens

      Volume: 15(7) Issue: 7 Pages: e1007919-e1007919

    • DOI

      10.1371/journal.ppat.1007919

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Infection of human tracheal epithelial cells by H5 avian influenza virus is regulated by the acid stability of hemagglutinin and the pH of target cell endosomes.2019

    • Author(s)
      Daidoji, T., Kajikawa, J., Arai, Y., Watanabe, Y., Hirose, R., Nakaya, T.
    • Journal Title

      Viruses

      Volume: 12 Issue: 1 Pages: 82-82

    • DOI

      10.3390/v12010082

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor2019

    • Author(s)
      Takeuchi Toshifumi、Sriwilaijaroen Nongluk、Sakuraba Ayako、Hayashi Ei、Kamisuki Shinji、Suzuki Yasuo、Ohrui Hiroshi、Sugawara Fumio
    • Journal Title

      Molecules

      Volume: 24 Issue: 14 Pages: 2603-2603

    • DOI

      10.3390/molecules24142603

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Demethylation around the transcriptional start site of the IFN-β gene induces IFN-β production and protection against influenza virus infection2019

    • Author(s)
      Nishioka Keisuke、Daidoji Tomo、Nakaya Takaaki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 520 Issue: 2 Pages: 269-276

    • DOI

      10.1016/j.bbrc.2019.09.136

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Situations leading to reduced effectiveness of current hand hygiene against infectious mucus from influenza-infected patients.2019

    • Author(s)
      Hirose R, Nakaya T, Naito Y, Daidoji T, Bandou R, Inoue K, Dohi O, Yoshida N, Konishi H, Itoh Y.
    • Journal Title

      mSphere

      Volume: 4 Issue: 5

    • DOI

      10.1128/msphere.00474-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals.2019

    • Author(s)
      Arai Y, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Suzuki Y, Nakaya T, Matsumoto K, Watanabe Y.
    • Journal Title

      J Virol.

      Volume: 93(4) Issue: 4

    • DOI

      10.1128/jvi.01969-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of the critical viscoelastic factor in the performance of submucosal injection materials2019

    • Author(s)
      Hirose Ryohei, Nakaya Takaaki, Naito Yuji, Daidoji Tomo, Dohi Osamu, Yoshida Naohisa, Yasuda Hiroaki, Konishi Hideyuki, Itoh Yoshito
    • Journal Title

      Materials Science & Engineering C

      Volume: 94 Pages: 909-919

    • DOI

      10.1016/j.msec.2018.10.051

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates2018

    • Author(s)
      Arai Y, Kawashita N, Hotta K, Hoang PVM, Nguyen HLK, Nguyen TC, Vuong CD, Le TT, Le MTQ, Soda K, Ibrahim MS, Daidoji T, Takagi T, Shioda T, Nakaya T, Ito T, Hasebe F, Watanabe Y.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 13066-13066

    • DOI

      10.1038/s41598-018-31397-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of H5N1 influenza virus quasispecies with adaptive hemagglutinin mutations from single-virus infections of human airway cells2018

    • Author(s)
      1.Watanabe Y**, Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Kajikawa J, Hiramatsu H, Sriwilaijaroen N, Ono T, Takagi T, Takahashi K, Shioda T, Matsumoto K, Suzuki Y, Nakaya T
    • Journal Title

      J Virol.

      Volume: 印刷中 Issue: 11

    • DOI

      10.1128/jvi.02004-17

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] N-glycan structures of human alveoli provide insight into influenza A virus infection and pathogenesis2018

    • Author(s)
      Nongluk Sriwilaijaroen, Shin-ichi Nakakita, Sachiko Kondo, Hirokazu Yagi, Koichi Kato, Takeomi Murata, Hiroaki Hiramatsu, Toshio Kawahara, Yohei Watanabe, Yasushi Kanai, Takao Ono, Jun Hirabayashi, Kazuhiko Matsumoto, Yasuo Suzuki
    • Journal Title

      The FEBS Journal

      Volume: 285 Issue: 9 Pages: 1611-1634

    • DOI

      10.1111/febs.14431

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A live attenuated vaccine prevents replication and transmission of H7N9 highly pathogenic influenza viruses in mammals2018

    • Author(s)
      Yang Wenyu, Yin Xin, Guan Lizheng, Li Mei, Ma Shujie, Shi Jianzhong, Deng Guohua, Suzuki Yasuo, Chen Hualan
    • Journal Title

      Emerging Microbes & Infections

      Volume: 7(1) Issue: 1 Pages: 153-153

    • DOI

      10.1038/s41426-018-0154-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diversity of influenza A(H5N1) Viruses in infected humans, Northern Vietnam, 2004-2010.2018

    • Author(s)
      Imai H, Dinis JM, Zhong G, Moncla LH, Lopes TJS, McBride R, Thompson AJ, Peng W, Le MTQ, Hanson A, Lauck M, Sakai-Tagawa Y, Yamada S, Eggenberger J, O'Connor DH, Suzuki Y, Hatta M, Paulson JC, Neumann G, Friedrich TC, Kawaoka Y.
    • Journal Title

      Emerg Infect Dis

      Volume: 24 Issue: 7 Pages: 1128-1238

    • DOI

      10.3201/eid2407.171441

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Irradiation by ultraviolet light-emitting diodes inactivates influenza a viruses by inhibiting replication and transcription of viral RNA in host cells2018

    • Author(s)
      Nishisaka-Nonaka Risa、Mawatari Kazuaki、Yamamoto Tomomi、Kojima Mizuki、Shimohata Takaaki、Uebanso Takashi、Nakahashi Mutsumi、Emoto Takahiro、Akutagawa Masatake、Kinouchi Yohsuke、Wada Takahiro、Okamoto Masayuki、Ito Hiroshi、Yoshida Ken-ichi、Daidoji Tomo、Nakaya Takaaki、Takahashi Akira
    • Journal Title

      Journal of Photochemistry and Photobiology B: Biology

      Volume: 189 Pages: 193-200

    • DOI

      10.1016/j.jphotobiol.2018.10.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance2018

    • Author(s)
      Hirose Ryohei, Daidoji Tomo, Naito Yuji, Dohi Osamu, Yoshida Naohisa, Yasuda Hiroaki, Konishi Hideyuki, Nakaya Takaaki, Itoh Yoshito
    • Journal Title

      Journal of Visualized Experiment

      Volume: 140 Issue: 140

    • DOI

      10.3791/58029

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between periodontal disease and butyric acid produced by periodontopathic bacteria2018

    • Author(s)
      Shirasugi Michihiro, Nakagawa Maki, Nishioka Keisuke, Yamamoto Toshiro, Nakaya Takaaki, Kanamura Narisato
    • Journal Title

      Inflammation and Regeneration

      Volume: 38 Issue: 1 Pages: 23-23

    • DOI

      10.1186/s41232-018-0081-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a new ex vivo model for evaluation of endoscopic submucosal injection materials performance2018

    • Author(s)
      Hirose Ryohei、Nakaya Takaaki、Naito Yuji、Daidoji Tomo、Yasuda Hiroaki、Konishi Hideyuki、Itoh Yoshito
    • Journal Title

      J Mech Behav Biomed Mater.

      Volume: 79 Pages: 219-225

    • DOI

      10.1016/j.jmbbm.2018.01.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique Infectious Strategy of H5N1 Avian Influenza Virus Is Governed by the Acid-Destabilized Property of Hemagglutinin.2017

    • Author(s)
      Daidoji T**, Watanabe Y, Arai Y, Kajikawa J, Hirose R, Nakaya T
    • Journal Title

      Viral Immunol.

      Volume: 30 Issue: 6 Pages: 398-407

    • DOI

      10.1089/vim.2017.0020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Viscosity is an important factor of resistance to alcohol-based disinfectants by pathogens present in mucus.2017

    • Author(s)
      Hirose R, Nakaya T**, Naito Y, Daidoji T, Watanabe Y, Yasuda H, Konishi H, Itoh Y.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 13186-13186

    • DOI

      10.1038/s41598-017-13732-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism of Human Influenza Virus RNA Persistence and Virion Survival in Feces: Mucus Protects Virions From Acid and Digestive Juices.2017

    • Author(s)
      Hirose R, Nakaya T**, Naito Y, Daidoji T, Watanabe Y, Yasuda H, Konishi H, Itoh Y.
    • Journal Title

      J Infect Dis.

      Volume: 216 Issue: 1 Pages: 105-109

    • DOI

      10.1093/infdis/jix224

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recombinant avian paramyxovirus serotypes 2, 6, and 10 as vaccine vectors for highly pathogenic avian influenza in chickens with antibodies against Newcastle disease virus.2017

    • Author(s)
      Tsunekuni R, Hikono H, Tanikawa T, Kurata R, Nakaya T, Saito T
    • Journal Title

      Avian Dis.

      Volume: 61 Issue: 3 Pages: 296-306

    • DOI

      10.1637/11512-100616-regr1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from pigeons.2017

    • Author(s)
      Elgendy EM, Arai Y, Kawashita N, Daidoji T, Takagi T, Ibrahim MS, Nakaya T, Watanabe Y
    • Journal Title

      J Gen Virol.

      Volume: 98 Issue: 1 Pages: 6-17

    • DOI

      10.1099/jgv.0.000674

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Glycan-functionalized graphene-FETs toward selective detection of human-infectious avian influenza virus2017

    • Author(s)
      Takao Ono
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 3 Pages: 030302-030302

    • DOI

      10.7567/jjap.56.030302

    • NAID

      210000147449

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses2016

    • Author(s)
      Arai Y, Kawashita N, Daidoji T, Ibrahim MS, El-Gendy EM, Takagi T, Takahashi K, Suzuki Y, Ikuta K, Nakaya T, Shioda T, Watanabe Y
    • Journal Title

      PLoS Pathog.

      Volume: 12 Issue: 4 Pages: e1005583-e1005583

    • DOI

      10.1371/journal.ppat.1005583

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic characterization of highly pathogenic avian influenza H5N1 viruses isolated from naturally infected pigeons in Egypt2016

    • Author(s)
      Elgendy EM, Watanabe Y, Daidoji T, Arai Y, Ikuta K, Ibrahim MS, Nakaya T
    • Journal Title

      Virus Genes

      Volume: 52 Issue: 6 Pages: 867-871

    • DOI

      10.1007/s11262-016-1369-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Long-term detection of seasonal influenza RNA in faeces and intestine.2016

    • Author(s)
      Hirose R, Daidoji T, Naito Y, Watanabe Y, Arai Y, Oda T, Konishi H, Yamawaki M, Itoh Y, Nakaya T.
    • Journal Title

      Clin Microbiol Infect

      Volume: 22 Issue: 9 Pages: 813-813

    • DOI

      10.1016/j.cmi.2016.06.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients.2015

    • Author(s)
      1.Watanabe Y, Arai Y, Daidoji T, Kawashita N, Ibrahim MS, El-Gendy E, Hiramatsu H, Kubota-Kokestu R, Takagi T, Murata T, Takahashi K, Okuno Y, Nakaya T, Suzuki Y, Ikuta K.
    • Journal Title

      mBio

      Volume: 6 Issue: 2

    • DOI

      10.1128/mbio.00081-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] H5N1鳥インフルエンザウイルスHAの宿主適応機構2015

    • Author(s)
      渡邊洋平、大道寺智、中屋隆明
    • Journal Title

      ウイルス

      Volume: 65 Pages: 187-198

    • NAID

      130005431375

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] Accumulation of PA mutations in Egyptian H5N1 viruses during viral evolution conferred the increased replication ability2019

    • Author(s)
      Yasuha Arai, Emad M. Elgendy, Tomo Daidoji, Madiha S. Ibrahim, Takaaki Nakaya, Yohei Watanabe
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] H5N1 avian influenza virus infection in human primary tracheal epithelial cells and their immortalized clones2019

    • Author(s)
      Tomo Daidoji, Junichi Kajikawa, Yohei Watanabe, Yasuha Arai, Takaaki Nakaya
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Adaptation dynamics of H5N1 avian influenza virus hemagglutinin during replication in human airway microenvironment2018

    • Author(s)
      Yohei Watanabe
    • Organizer
      Asian-Pacific Centenary Spanish 1918-flu Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Characterization of H5N1 avian influenza virus quasipspecies with adaptive hemagglutinin mutations from single-virus infections of human airway cells2018

    • Author(s)
      Yohei Watanabe
    • Organizer
      Negative Strand Virus Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic compatibility and virulence of reassortants derived from H9N2 and H5N1 avian influenza viruses co-circulating in Egypt2018

    • Author(s)
      Yasuha Arai
    • Organizer
      Negative Strand Virus Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evolutionally dynamics of Egyptian H9N2 aviann influenza virus in nature conferred enhanced replication ability in humans2018

    • Author(s)
      Yasuha Arai, Ibrahim Madiha, Elgendy Emad, Tomo Daidoji, Takaaki Nakaya, Yohei Watanabe
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characterization of H9N2 avian influenza viruses with NA stalk deletion that was firstly detected in Egypt2018

    • Author(s)
      Yohei Watanabe, Arai Yasuha, Ibrahim Madiha S., Elgendy Emad M., Daidoji Tomo, Suzuki Yasuo, Nakaya Takaaki
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Evaluation of avian influenza virus infection in human tracheal epithelial cell clones2018

    • Author(s)
      Daidoji Tomo. Kajikawa Junichi, Watanabe Yohei, Arai Yasuha, Nakaya Takaaki
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Establishment of infection experiment system using aerosolized influenza virus2018

    • Author(s)
      Kawada Kaho, Nishioka Keisuke, Daidoji Tomo, Nakaya Takaaki
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Adenosine analog inhibits replication of protozoan endogenous dsRNA: Leishmaniavirus (LRV2) and Cryspovirus (CSpV1)2018

    • Author(s)
      Murakoshi Fumi, Shichinohe Shintaro, Hayashi Miwa, Tanaka Yutaro, Sanjyoba Chizu, Matsumono Yoshitsugu, Nakaya Takaaki
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Possibility of Mx expression to reflect differences in Influenza virus susceptibility in birds2018

    • Author(s)
      Hagiwara Katsuro, Nakaya Takaaki, Onuma Manabu
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト気管上皮由来細胞株における鳥インフルエンザウイルスの感染様式について2018

    • Author(s)
      大道寺智
    • Organizer
      第32回インフルエンザ研究者交流の会シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 分化条件下における鳥インフルエンザウイルスのヒト呼吸器上皮由来細胞株への感染様式について2018

    • Author(s)
      大道寺智
    • Organizer
      7th Negative Strand Virus-Japan Symposium
    • Related Report
      2017 Annual Research Report
  • [Presentation] Changing nature of H5N1 avian influenza virus in Egypt2018

    • Author(s)
      Watanabe Y
    • Organizer
      2nd Kyoto International Symposium on Virus-Host Coevolution
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Characterization of H5N1 influenza virus variants with adaptive mutations isolated from patients2017

    • Author(s)
      Watanabe Y
    • Organizer
      The Sixth China-Japan Bilateral Symposium on All Influenza Viruses
    • Place of Presentation
      Beijing, China
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 季節性インフルエンザウイルスの腸管感染とそのメカニズムについて2017

    • Author(s)
      中屋隆明
    • Organizer
      6th Negative Strand Virus-Japan Sympodium
    • Place of Presentation
      沖縄
    • Year and Date
      2017-01-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Adaptive change of H5N1 avian influenza virus circulating in Egypt2017

    • Author(s)
      Watanabe Y
    • Organizer
      Interim workshop for project on infectious diseases in Vietnam and development of application in diagnosis, prevention and treatment
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identification of novel polymerase gene mutations for human adaptation in clinical isolates of avian H5N1 influenza virus in Asia2017

    • Author(s)
      Arai Y
    • Organizer
      Interim workshop for project on infectious diseases in Vietnam and development of application in diagnosis, prevention and treatment
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Characterization of H5N1 influenza virus with HA mutations diversified in human airway epithelial cells as minor variants2017

    • Author(s)
      Watanabe Y
    • Organizer
      JSPS Core-to-Core Program 2nd Scientific Seminar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Co-circulation of H9N2 and H5N1 avian influenza in Egypt and their reassortment potential2017

    • Author(s)
      Arai Y
    • Organizer
      JSPS Core-to-Core Program 2nd Scientific Seminar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Avian influenza virus infection in human airway epithelial cell model2017

    • Author(s)
      Daidoji T
    • Organizer
      JSPS Core-to-Core Program 2nd Scientific Seminar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of H5N1 influenza virus with HA mutations diversified in human airway epithelial cells as minor variants2017

    • Author(s)
      Watanabe Y, Arai Y, Kawashita N, Daidoji T, Elgendy EM, Ibrahim MS, Kajikawa J, Hiramatsu H, Takagi T, Takahashi K, Shioda T, Suzuki Y, Nakaya T
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel polymerase gene mutations for human adaptation in clinical isolates of Avian H5N1 influenza virus in Asia2017

    • Author(s)
      Arai Y, Kawashita N, Hotta K, Hoang MPV, Nguyen KHL, Nguyen TC, Vuong CD, Le MQ, Soda K, Kajikawa J, Daidoji T, Nakaya T, Takagi T, Ito T, Hasebe H, Shioda T, Watanabe Y
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evaluation of avian influenza virus infection in differentiated airway epithelial cells2017

    • Author(s)
      Daidoji T, Noguchi M, Kajikawa J, Watanabe Y, Arai Y, Hirose R, Morimoto M, Nakaya T
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Mechanism of seasonal influenza virus persistence in human digestive tract: Mucus protects virions from acid and digestive juices2017

    • Author(s)
      Nakaya T, Hirose R, Daidoji T, Naito Y, Watanabe Y, Arai Y, Kawada K, Kajikawa J, Yamawaki M, Itoh Y
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Establishment of immortalized cell clones from human tracheal epithelial cells and their different susceptibility to influenza viruses2017

    • Author(s)
      Kajikawa J, Daidoji T, Watanabe Y, Arai Y, Hirose R, Nakaya T
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characterization of H5N1 influenza virus variants with HA mutations selected during the viral replication in human airway epithelial cells2016

    • Author(s)
      Watanabe Y
    • Organizer
      Egypt-Japan First Forum. The Year of Education and Research Collaboration
    • Place of Presentation
      Damanhour, Egypt
    • Year and Date
      2016-12-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Kaizen way to self-improvement2016

    • Author(s)
      Watanabe Y
    • Organizer
      Egypt-Japan First Forum. The Year of Education and Research Collaboration
    • Place of Presentation
      Damanhour, Egypt
    • Year and Date
      2016-12-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Characterization of H5N1 influenza virus variants with HA mutations selected during the viral replication in human airway epithelial cells2016

    • Author(s)
      Watanabe Y, Arai Y, Daidoji T, Elgendy EM, Ibrahim MS, Takahashi K, Shioda T, Ikuta K, Suzuki Y, Nakaya T
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Hemagglutinin acid stability and viral infection in H7 influenza virus2016

    • Author(s)
      Daidoji T, Elgendy EM, Watanabe Y, Arai Y, Ibrahim MS, Ikuta K, Nakaya T
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Novel polymerase gene mutations for human adaptation in clinical isolates of avian H5N1 influenza viruses2016

    • Author(s)
      Arai Y, Kawashita N, Daidoji T, Ibrahim MS, Takayashi K, Suzuki Y, Nakaya T, Shioda T, Ikuta K, Watanabe Y
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of unique mutations that influence the polymerase activity of H5N1 avian influenza virus isolated from pigeons2016

    • Author(s)
      Elgendy EM, Arai Y, Ibrahim MS, Daidoji T, Ikuta K, Nakaya T, Watanabe Y
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Novel Polymerase Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses2016

    • Author(s)
      Watanabe Y
    • Organizer
      The 11th Japan-China International Conference of Virology
    • Place of Presentation
      香川
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 鳥インフルエンザ-H5N1/H7N9を中心に-2016

    • Author(s)
      中屋隆明
    • Organizer
      第31回日本環境感染症学会総会
    • Place of Presentation
      京都
    • Year and Date
      2016-02-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] H7鳥インフルエンザにおけるHA蛋白質のpH感受性について2016

    • Author(s)
      大道寺 智
    • Organizer
      5th Negative Strand Virus-Japan Symposium
    • Place of Presentation
      沖縄
    • Year and Date
      2016-01-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Genetic diversification of H5N1 avian influenza virus variants during replication in human airway epithelial cells2015

    • Author(s)
      Yohei Watanabe, Yasuha Arai, Tomo Daidoji, Madiha S Ibrahim, Emad Elgendy, Kazuo Takahashi, Yasuo Suzuki, Tatsuo Shioda, Kazuyoshi Ikuta, Takaaki Nakaya
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dynamics of influenza A virus infection in mucin-type glycosyltransfererase Galnt3-knockout mice2015

    • Author(s)
      Shoko Nakamura, Tomo Daidoji, Tomoyuki Honda, Takaaki Nakaya, Toshihisa Komori, Keizo Tomonaga
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Hemagglutinin acid stability in H7 influenza virus infection to host cells2015

    • Author(s)
      Tomo Daidoji, Emad Elgendy, Yohei Watanabe, Kazuyoshi Ikuta, Takaaki Nakaya
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of human adaptive mutations in the polymerase complex of H5N1 avian influenza virus in Egypt2015

    • Author(s)
      Yasuha Arai, Tomo Didoji, Madiha S. Ibrahim, Kazuo Takahashi, Yasuo Suzuki, Takaaki Nakaya, Tatsuo Shioda, Kazuyoshi Ikuta, Yohei Watanabe
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Genetic characterization of H5N1 avian influenza virus from pigeon in Egypt 20092015

    • Author(s)
      Emad Elgendy, Madiha S. Ibrahim, Arai Yasuha, Tomo Daidoji, Yohei Watanabe, Takaaki Nakaya
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Book] 鳥インフルエンザウイルスの糖鎖を介したヒト適応機構とパンデミック対策2016

    • Author(s)
      渡邊洋平
    • Publisher
      Glycoforum
    • Related Report
      2015 Annual Research Report
  • [Remarks] http://www.f.kpu-m.ac.jp/k/did/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 京都府立医科大学感染病態学研究室HP

    • URL

      http://www.f.kpu-m.ac.jp/k/did/

    • Related Report
      2018 Annual Research Report
  • [Remarks] http://www.f.kpu-m.ac.jp/k/did/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 京都府立医科大学・医学研究科・感染病態学HP

    • URL

      http://www.f.kpu-m.ac.jp/k/did/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 京都府立医科大学・医学研究科・感染病態学教室HP

    • URL

      http://www.f.kpu-m.ac.jp/k/did/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-11-04  

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