Promoting healthy fetal and post natal growth by modulating vaginal or gut microbiota with supplementation of prebiotic agent in pregnent women

• Project/Area Number: 15H05296
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Pediatrics
• Research Institution: University of Tsukuba
• Principal Investigator: Wagatsuma Yukiko 筑波大学, 医学医療系, 教授 (40400676)
• Co-Investigator(Kenkyū-buntansha): 馬 恩博 福島県立医科大学, 健康増進センター, 准教授 (00590770) ; 福島 敬 筑波大学, 医学医療系, 准教授 (30323299) ; 須磨崎 亮 筑波大学, 医学医療系, 客員教授 (40163050)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: 医療・福祉 / 小児科 / 社会医学 / 栄養学 / 微生物

Outline of Final Research Achievements

Low birth weight (LBW) is one of the most important public health issues. LBW affects throughout life-span relating to chronic diseases. Genitourinary infections are known to cause LBW. The maintenance of normal microbiota prevents various infections in human. However, it is unknown that it also affects fetal growth restriction. Therefore, this study aimed to examine the effect of daily supplementation of prebiotics during pregnancy and assess birth outcomes in Bangladesh. There was no observed difference in birth weight between intervention and placebo groups. However, notable improvement in weight gain during pregnancy was observed.

Research Products

• [Int'l Joint Research] 国際下痢症研究センター（ICDDR,B) (バングラデシュ)
• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Int'l Joint Research] University of Queensland(オーストラリア)
• [Int'l Joint Research] 国際下痢症研究センター(ICDDR,B)(バングラデシュ)
• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Int'l Joint Research] 国際下痢症研究センター（icddr,b）(バングラデシュ)
• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Presentation] Respiratory function in children relates to chronic malnutrition trajectory: birth cohort study in Bangladesh (2017)
  • Author(s): Ferdous F, Rashid H, Ma E, Ahmed S, Raqib R, Wagatsuma Y.
  • Organizer: The 27th Annual Scientific Meeting of the Japan Epidemiological Association
  • Place of Presentation: The Bellclassic Kofu, Kofu, Japan
  • Year and Date: 2017-01-25
• [Presentation] Small size of kidney and blood pressure of Bangladeshi children. (2017)
  • Author(s): Ferdous F, Ma E, Ahmed S, Raqib R, Wagatsuma Y.
  • Organizer: The 21st International Epidemiological Association World Congress of Epidemiology 2017
  • Int'l Joint Research
• [Presentation] Pneumonia deaths in young children. (2017)
  • Author(s): Ferdous F, Ahmed S, Das SK, Chisti MJ, Nasrin D, Kotloff KL, Levine MM, Nataro JP, Ma E, Muhsen K , Wagatsuma Y, Ahmed T, Faruque ASG.
  • Organizer: Tsukuba Global Science Week 2017
  • Int'l Joint Research
• [Presentation] Early pregnancy nutritional status and estimated fetal weight: observation from a Bangladesh cohort. (2017)
  • Author(s): Ferdous F, Raqib R, Wagatsuma Y.
  • Organizer: 第58回日本熱帯医学会大会 Global Health 2017
• [Presentation] Lung function at preadolescence in low birthweight children in Bangladesh. (2016)
  • Author(s): Ferdous F, Rashid H, Ma E, Ahmed S, Raqib R, Wagatsuma Y
  • Organizer: The 31st Annual Meeting of the Japan Association for International Health
  • Place of Presentation: Kurume City Plaza, Kurume, Japan
  • Year and Date: 2016-12-03
• [Presentation] Fetal growth in Bangladesh (2016)
  • Author(s): Wagatsuma Y, Ferdous Y, Rashid H, Arifeen SE.
  • Organizer: The International Congress of Tropical Medicine and Malaria 2016
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2016-09-18
  • Int'l Joint Research
• [Presentation] Maternal malnutrition, prenatal growth, and renal size of Bangladeshi children. (2016)
  • Author(s): Ferdous F, Rashid H, Ma E, Raqib R, Wagatsuma Y.
  • Organizer: International Congress for Tropical Medicine and Malaria 2016
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2016-09-18
  • Int'l Joint Research
• [Presentation] Maternal supplementation of prebiotics to promote healthy fetal and post-natal growth (2016)
  • Author(s): Farhana Ferdousi, Shamima Sultana, Enbo Ma,Shafiqul A. Sarker, Yukiko Wagatsuma
  • Organizer: Tunisia-Japan Symposium on Science, Society and Technology 2015
  • Place of Presentation: 筑波大学大学会館（茨城県）
  • Year and Date: 2016-02-23
  • Int'l Joint Research
• [Presentation] Promoting healthy fetal and post-natal growth with supplementation of prebiotics in pregnant women (2016)
  • Author(s): Farhana Ferdousi, Shamima Sultana, Enbo Ma, Shafiqul A. Sarker, Yukiko Wagatsuma
  • Organizer: The 26th Annual Scientific Meeting of the Japan Epidemiological Association
  • Place of Presentation: 米子コンベンションセンター（鳥取県）
  • Year and Date: 2016-01-21
• [Presentation] Poverty, climate change and fetal growth (2015)
  • Author(s): Yukiko Wagatsuma
  • Organizer: The 30th Japan Association for International Health Congress 2015
  • Place of Presentation: 金沢大学自然科学本館（石川県）
  • Year and Date: 2015-11-21
  • Int'l Joint Research
• [Presentation] Changing childhood malnutrition in Bangladesh (2015)
  • Author(s): A.S.G. Faruque
  • Organizer: The 30th Japan Association for International Health Congress 2015
  • Place of Presentation: 金沢大学自然科学本館（石川県）
  • Year and Date: 2015-11-21
  • Int'l Joint Research
• [Presentation] The role of pro- and prebiotic agents in the treatment and prevention of infectious diarrhoea in children (2015)
  • Author(s): Shafiqul A. Sarker
  • Organizer: The 30th Japan Association for International Health Congress 2015
  • Place of Presentation: 金沢大学自然科学本館（石川県）
  • Year and Date: 2015-11-21
  • Int'l Joint Research
• [Funded Workshop] The 21st International Epidemiological Association World Congress of Epidemiology 2017, Symposium 18: Measurement, evaluation and disease control with longitudinal data analysis (2017)
• [Funded Workshop] The 30th Japan Association for International Health Congress, International Mini-symposium (2015)
  • Place of Presentation: 金沢大学自然科学本館（石川県）
  • Year and Date: 2015-11-21