| Project/Area Number |
15H05301
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Social dentistry
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| Research Institution | Neuropsychiatric Research Institute |
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Principal Investigator |
TSUIKI Satoru 公益財団法人神経研究所, 研究部, 研究員 (90376765)
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| Co-Investigator(Kenkyū-buntansha) |
田賀 仁 昭和大学, 医学部, 講師 (00568917)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOH Eiki 公益財団法人神経研究所, 研究部, 研究員 (90287681)
KOBAYASHI Mina 公益財団法人神経研究所, 研究部, 研究員 (40596037)
NAKAYAMA Hideaki 東京医科大学, 医学部, 准教授 (30444144)
INOUE Yuichi 公益財団法人神経研究所, 研究部, 研究員 (50213179)
ISONO Shiroh 千葉大学, 大学院医学研究院, 教授 (80212968)
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| Research Collaborator |
KOHZUKA Yuuya
ENO Yukiko
EBATO Arisa
Almeida Fernanda
Pliska Benjamin
Harrison Sandra
Wong Mary
Ellis Ingrid
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 睡眠時無呼吸症候群 / 歯列弓 / 解剖学的バランス / 顎顔面形態 / 人種差 / 閉塞性睡眠時無呼吸症候群 / 歯列 / 人種間比較 / コーカソイド / 日本人 / 口腔内容積 |
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| Outline of Final Research Achievements |
Obesity is a major factor which increases the collapsibility of the upper airway in Caucasian patients with Obstructive Sleep Apnea (OSA). In contrast, cranio- and dentofacial factors could be mainly involved in the development of OSA in Asian people who are less obese in comparison with Caucasians. However, clinically, not all Caucasian OSA patients are obese, similarly not all Japanese OSA patients have OSA due to craniofacial factors. We hypothesized that, when the severity of OSA in addition to obesity was matched between the two races, there would be lesser anatomic differences between Japanese and Caucasian OSA patients. Based on our dental model and cephalometric analysis, we conclude that (1)Japanese OSA have larger tongue and dental arch /maxillo-mandibular sizes in comparison with Caucasian OSA and (2)if the degrees of oropharyngeal crowding are the same between the two races, it will lead to the same degree of OSA severity, independent of race.
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