| Budget Amount *help |
¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
The present study aimed at understanding biological effects of a variety of chemicals and their molecular mechanisms, with particular emphasis on signaling pathways involving cellular receptors, using zebrafish as a model organism. Some of the biological effects identified include cytochrome P450 induction, cardiovascular toxicity, and endocrine disruption, through the cellular receptors such as pregnane X receptor (PXR), aryl hydrocarbon receptor type 2 (AHR2) and estrogen receptors (ERs). The current study also suggest that in silico simulations of interaction between chemicals and ER subtypes can predict in vivo potency of the ER-mediated response by untested chemical substances.
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