| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2015: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Outline of Final Research Achievements |
We focused a smut fungi Pseudozyma hubeiensis as cell factory for producing mannosylerythritol lipids (MEL), which are attractive material as a next generation eco-frendly surface active reagenet. Using genetics and metabolic engineering, non-natural MEL was attempted to produced selectively and efficently by the mutants. Deacetylated MEL (MEL-D) was synthesized by a acetyltransferase-knock out mutant, and was characterized as a surfactant. Furthermore, a novel tryacylated MEL-D was also synthesized.
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