Dietary obesity and metabolic syndrome: Host energy regulation via short-chain fatty acid receptors by gut microbiota
| Project/Area Number |
15H05344
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
Kimura Ikuo 東京農工大学, (連合)農学研究科(研究院), 准教授 (80433689)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2015: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 腸内細菌 / 食物繊維 / 短鎖脂肪酸 / 脂肪酸受容体 / 肥満 / 生活習慣病 / GPR41 / GPR43 / GPCR / 短鎖脂肪酸受容体 / 食品薬理 / 薬理栄養 |
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| Outline of Final Research Achievements |
In this study, we focused on short-chain fatty acids (SCFAs) produced by gut microbial fermentation from indigestible polysaccharides such as dietary fiber, and the SCFA receptors. Then, we aimed at an integrated elucidation of beneficial metabolic effects via dietary fiber and gut microbiota.
As a result of this research, we clarified that gut microbial SCFAs shows resistance to host obesity by controlling adipose inflammation via GPR43. Moreover, we revealed that the beneficial metabolic effect by barley flour depends on SCFAs produced from barley beta-glucan (dietary fiber) by the gut microbiota.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice2017
Author(s)
Nakajima, A. Kaga, N. Nakanishi, Y. Ohno, H. Miyamoto, J. Kimura, I. Hori, S. Sasaki, T. Hiramatsu, K. Okumura, K. Miyake, S. Habu, S. Watanabe, S.
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Journal Title
J Immunol
Volume: 199
Issue: 10
Pages: 3516-3524
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Gut microbiota and obesity2017
Author(s)
I. Kimura
Organizer
5th Biennial Congress of the Asian Neurogastroenterology & Motility Association
Place of Presentation
Osaka-fu, Osaka-shi, Osaka International Convention Center
Year and Date
2017-03-23
Related Report
Int'l Joint Research / Invited
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[Presentation] 腸内細菌代謝産物と肥満2015
Author(s)
木村 郁夫
Organizer
第15回日本抗加齢医学会総会
Place of Presentation
福岡国際会議場（福岡市・博多区）
Year and Date
2015-05-29
Related Report
Invited
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