| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2015: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Outline of Final Research Achievements |
In this study, we focused on short-chain fatty acids (SCFAs) produced by gut microbial fermentation from indigestible polysaccharides such as dietary fiber, and the SCFA receptors. Then, we aimed at an integrated elucidation of beneficial metabolic effects via dietary fiber and gut microbiota.
As a result of this research, we clarified that gut microbial SCFAs shows resistance to host obesity by controlling adipose inflammation via GPR43. Moreover, we revealed that the beneficial metabolic effect by barley flour depends on SCFAs produced from barley beta-glucan (dietary fiber) by the gut microbiota.
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