| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
|
|---|
| Outline of Final Research Achievements |
In this work, to quantitatively understand dynamic adhesion process of cancer cells, interface structures and mechanical properties of cancer cells have been characterized by using various optical/mechanical measurement techniques together with functional materials. The project gained mainly the following two achievements. (1) New experimental platforms for the quantitative evaluation of cancer cell adhesion was developed, which can be used to identify metastatic ability of cancer cells and to carry out drug screening. (2) Physico-chemical measurement revealed that green tea catechin with galloyl moiety can be physically adsorbed to phospholipid membranes, which leads to the significant stiffening of phospholipid membranes. This finding will be useful to design a new class of drugs for cancer therapy from mechanical viewpoints.
|
