| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Outline of Final Research Achievements |
In this work, the novel hydrogel system for cell-based therapy of Parkinson's disease could be constructed. From the animal experiment, it was demonstrated that this hydrogel system improved the graft survival and facilitated the differentiation into dopamine neuron of engrafted cells, and the disease state improved drastically by using this hydrogel system. Additionally, I evaluated the mechanism for the regeneration of nerual network by cell-hydrogel co-transplantation. From these study, it was indicated that 1) hydrogel system slightly degrades in the state of the differentiation into dopamine neurons and does not inhibit the integration between transplanted dopamine neurons and host striatum, 2) dopamine neurons in hydrogel system construct the neural network and carry out the electrical transmission. These results are very important information to put this hydrogel system to practical use.
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