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Multimodal Assesment for Neurosurgical Diseases Employing Simultaneous Measurement of ECoG, Hemodynamics, and Temperature Destribution

Research Project

Project/Area Number 15H05356
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Medical systems
Research InstitutionKumamoto University

Principal Investigator

Yamakawa Toshitaka  熊本大学, 大学院先導機構, 助教 (60510419)

Research Collaborator Suzuki Michiyasu  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywordsマルチモダリティセンサ / 生体埋込型デバイス / フレキシブル回路 / マルチモダリティ脳計測 / NIRS / ECoG / 皮質温度分布 / 電子デバイス・機器 / 脳・神経 / 先端機能デバイス
Outline of Final Research Achievements

The development of a flexible multi-modal multi-channel probe for the simultaneous measurement of the NIRS, ECoG, and surficial temperature obtained from the cerebral cortex was carried out. Photoelectric bare chips for NIRS channels, miniature temperature-coefficient thermistors for measuring localized temperature variation, and 3-mm-diameter platinum plates for ECoG recording were assembled on a polyimide-based flexible printed circuit to create six channels for each modality. A conformal coating of Parylene-C was applied on all the channels except the ECoG to make the probe surface biocompatible. Results: As a first-in-human study, the simultaneous measurement capability of the multi-modality probe, with sufficient signal-to-noise (S/N) ratio and accuracy, to observe pathological neural activities in subjects during surgery and post-operative monitoring, with no complications two weeks since the implantation, was confirmed.

Academic Significance and Societal Importance of the Research Achievements

臨床上の有用性が証明されている脳活動に関わる3種の情報を、一つのデバイスで同時に得る点に特徴があり、より多面的で信頼性の高い脳活動評価法の基盤的技術となり得る。提案手法は、難治性てんかんの術前・術中診断や、動脈瘤手術後の脳虚血・過還流に伴う脳血管攣縮の診断などには直接応用可能で、現行手法(硬膜下電極の慢性留置)と同等以下の侵襲でより信頼性の高い臨床診断材料が得られる。また、脳外科領域で近年注目されている病態である皮質拡延性抑制を継続的・多面的・定量的に観測する現状唯一の手立てとなることを示した。これらの成果は電子工学だけでなく臨床医学や基礎医学などの他分野の発展にも連鎖反応的に寄与し得る。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (34 results)

All 2019 2018 2017 2016 2015

All Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 8 results) Presentation (22 results) (of which Int'l Joint Research: 22 results,  Invited: 1 results)

  • [Journal Article] Limitations of Local Brain Cooling on Generalized Motor Seizures from Unknown Foci in Awake Rats2019

    • Author(s)
      He Y, Inoue T, Nomura S, Maruta Y, Kida H, Yamakawa T, Hirayama Y, Imoto H, Suzuki M.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 59 Issue: 4 Pages: 147-153

    • DOI

      10.2176/nmc.oa.2018-0112

    • NAID

      130007632870

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epileptic Seizure Suppression by Focal Brain Cooling With Recirculating Coolant Cooling System: Modeling and Simulation2019

    • Author(s)
      Hata Kei、Fujiwara Koichi、Inoue Takao、Abe Takuto、Kubo Takatomi、Yamakawa Toshitaka、Nomura Sadahiro、Imoto Hirochika、Suzuki Michiyasu、Kano Manabu
    • Journal Title

      IEEE Transactions on Neural Systems and Rehabilitation Engineering

      Volume: 27 Issue: 2 Pages: 162-171

    • DOI

      10.1109/tnsre.2019.2891090

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heart Rate Variability-based Driver Drowsiness Detection and its Validation with EEG2018

    • Author(s)
      Fujiwara Koichi、Abe Erika、Kamata Keisuke、Nakayama Chikao、Suzuki Yoko、Yamakawa Toshitaka、Hiraoka Toshihiro、Kano Manabu、Sumi Yukiyoshi、Masuda Fumi、Matsuo Masahiro、Kadotani Hiroshi
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 1 Issue: 6 Pages: 1-1

    • DOI

      10.1109/tbme.2018.2879346

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is hemifacial spasm affected by changes in the heart rate? A study using heart rate variability analysis2018

    • Author(s)
      Hamasaki Tadashi、Morioka Motohiro、Fujiwara Koichi、Nakayama Chikao、Harada Miho、Sakata Kiyohiko、Hasegawa Yu、Yamakawa Toshitaka、Yamada Kazumichi、Mukasa Akitake
    • Journal Title

      Clinical Neurophysiology

      Volume: 129 Issue: 10 Pages: 2205-2214

    • DOI

      10.1016/j.clinph.2018.07.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ischemic Stroke Detection by Analyzing Heart Rate Variability in Rat Middle Cerebral Artery Occlusion Model2018

    • Author(s)
      Kodama Tomonobu、Kamata Keisuke、Fujiwara Koichi、Kano Manabu、Yamakawa Toshitaka、Yuki Ichiro、Murayama Yuichi
    • Journal Title

      IEEE Transactions on Neural Systems and Rehabilitation Engineering

      Volume: 26 Issue: 6 Pages: 1152-1160

    • DOI

      10.1109/tnsre.2018.2834554

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 多変量統計的プロセス管理と心拍変動解析を用いたてんかん発作予知技術の開発2017

    • Author(s)
      藤原 幸一, 宮島 美穂, 鈴木 陽子, 山川 俊貴, 加納 学
    • Journal Title

      計測と制御

      Volume: 56(7) Pages: 526-529

    • NAID

      130005825168

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidural focal brain cooling abolishes neocortical seizures in cats and non-human primates2017

    • Author(s)
      Inoue Takao、Fujii Masami、Kida Hiroyuki、Yamakawa Toshitaka、Maruta Yuichi、Tokiwa Tatsuji、He Yeting、Nomura Sadahiro、Owada Yuji、Yamakawa Takeshi、Suzuki Michiyasu
    • Journal Title

      Neuroscience Research

      Volume: 122 Pages: 35-44

    • DOI

      10.1016/j.neures.2017.04.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential Temperature Sensitivity of Synaptic and Firing Processes in a Neural Mass Model of Epileptic Discharges Explains Heterogeneous Response of Experimental Epilepsy to Focal Brain Cooling2017

    • Author(s)
      Jaymar Soriano, Takatomi Kubo, Takao Inoue, Hiroyuki Kida,Toshitaka Yamakawa, Michiyasu Suzuki, Kazushi Ikeda
    • Journal Title

      PLoS Computational Biology

      Volume: 13 Issue: 10 Pages: e1005736-e1005736

    • DOI

      10.1371/journal.pcbi.1005736

    • NAID

      120006354240

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ウェアラブルデバイスとスマートフォンを用いたてんかん発作予知技術2017

    • Author(s)
      藤原 幸一, 宮島 美穂, 山川 俊貴
    • Journal Title

      Epilepsy

      Volume: 11(2) Pages: 7-13

    • NAID

      40021393720

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 運転中の能動的行為によるドライバの覚醒維持効果と運転安全性2017

    • Author(s)
      伊部 達朗, 平岡 敏洋, 阿部 恵里花, 藤原 幸一, 山川 俊貴
    • Journal Title

      自動車技術会論文集

      Volume: 48(2) Pages: 463-469

    • NAID

      130006734236

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Drowsiness Detection Method by Integrating Heart Rate Variability Analysis and Multivariate Statistical Process Control2016

    • Author(s)
      Erika Abe, Koichi Fujiwara, Toshihiro Hiraoka, Toshitaka Yamakawa, Manabu Kano
    • Journal Title

      SICE Journal of Control, Measurement, and System Integration

      Volume: 9 Pages: 10-17

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epileptic Seizure Prediction Based on Multivariate Statistical Process Control of Heart Rate Variability Features2015

    • Author(s)
      K. Fujiwara, M. Miyajima, T. Yamakawa, E. Abe, Y. Suzuki, Y. Sawada, M. Kano, T. Maehara, K. Ohta, T. Sasai-Sakuma, T. Sasano, M. Matsuura, and E. Matsushima
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 63 Issue: 6 Pages: 1321

    • DOI

      10.1109/tbme.2015.2512276

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Wearable and Implantable Electronics for Health and Clinical Care2019

    • Author(s)
      Toshitaka Yamakawa
    • Organizer
      5th International Conference on Nanoscience and Nanotechnology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Optimal Lead Selection Method to Improve Detection Rate of R-R Interval in Multiple-Lead Electrocardiogram2018

    • Author(s)
      Shun Sakai, Kento Shoji, Toshitaka Yamakawa, Tadashi Sakata, Yuichi Ueda
    • Organizer
      2018 IEEE Life Sciences Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Robust R-Wave Detection Under Long-Term Measurement Using HRV Sensor System with Automatic Gain Readjustment2018

    • Author(s)
      Kento Shoji, Toshitaka Yamakawa, Tadashi Sakata, Yuichi Ueda
    • Organizer
      2018 IEEE Life Sciences Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of False Heart Rate Feedback System for Improving Game Experience2018

    • Author(s)
      Sayaka Ogawa, Koichi Fujiwara, Toshitaka Yamakawa, Erika Abe, Manabu Kano
    • Organizer
      IEEE ICCE 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluating the Improvement Factor of R-Wave Detection Rate after Gain Readjustment2018

    • Author(s)
      Kento Shoji, Toshitaka Yamakawa, Koichi Fujiwara, Manabu Kano, Miho Miyajima, Tadashi Sakata, Yuichi Ueda
    • Organizer
      IEEE BHI 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimal Lead Selection Method for Improving Detection Rate of RRI from Multiple Leads Electrocardiogram2018

    • Author(s)
      Shun Sakai, Kento Shoji, Toshitaka Yamakawa, Tadashi Sakata, Yuichi Ueda
    • Organizer
      IEEE BHI 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generalized EpilepticSeizure Prediction and Mechanism Analysis by Using Heart Rate Variability2018

    • Author(s)
      Fumiya Sakane, Koichi Fujiwara, Miho Miyajima, Yoko Suzuki, Toshitaka Yamakawa, Manabu Kano, Taketoshi Maehara
    • Organizer
      IEEE BHI 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Seizure Prediction and Mechanism Analysis of Generalized Epilepsy based on Heart Rate Variability2017

    • Author(s)
      Fumiya Sakane, Koichi Fujiwara, Miho Miyajima, Yoko Suzuki, Toshitaka Yamakawa, Manabu Kano, Taketoshi Maehara
    • Organizer
      IEEE EMBC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A New Infarction Detection Method based on Heart Rate Variability in Rat Middle Cerebral Artery Occlusion Model2017

    • Author(s)
      Tomonobu Kodama, Keisuke Kamata, Koichi Fujiwara, Manabu Kano, Toshitaka Yamakawa, Ichiro Yuki, Yuichi Murayama
    • Organizer
      IEEE EMBC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimation of Skin Blood Flow Change in Recumbent Position using Surface-Type Photoplethysmography Sensor2017

    • Author(s)
      Sayaka Ogawa, Koichi Fujiwara, Toshitaka Yamakawa, Hiroshi Kadotani, Masahiro Matsuo, Manabu Kano
    • Organizer
      IEEE EMBC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Missing RRIi Interpolation Algorithm Using Just-In-Time Modeling Framework and Its Application to HRV-Based Drowsy Driving Detection2017

    • Author(s)
      Koichi Fujiwara, T. Kinoshita, Keisuke Kamata, Toshitaka Yamakawa, Manabu Kano
    • Organizer
      World Sleep Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Validation of HRV-Based Drowsy-Driving Detection Method with EEG Sleep Stage Classification2017

    • Author(s)
      T. Yamakawa, K. Fujiwara, T. Hiraoka, M. Kano, Y. Sumi, F. Masuda, M. Matsuo, H. Kadotani
    • Organizer
      World Sleep Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Automatic Selection Method of Optimal Lead for R-R Interval Measurement from Multiple Leads Electrocardiogram2017

    • Author(s)
      Shun Sakai, Kento Shoji, Toshitaka Yamakawa, Tadashi Sakata, Yuichi Ueda
    • Organizer
      IEEE LSC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gain Readjustment Function to Reduce Measurement Errors in Long-Term HRV Monitoring with a Wearable Telemeter2017

    • Author(s)
      Kento Shoji, Toshitaka Yamakawa, Koichi Fujiwara, Manabu Kano, Miho Miyajima, Tadashi Sakata, Yuichi Ueda
    • Organizer
      IEEE LSC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-Time Epileptic Seizure Prediction System Employing a Wearable HRV Telemeter and a Smartphone2016

    • Author(s)
      Miho Miyajima, Toshitaka Yamakawa, Koichi Fujiwara, Yuriko Sawada, Yoko Suzuki, Erika Abe, Manabu Kano, Satsuki Watanabe, Yoshiko Murata, Yutaka Watanabe, Taketoshi Maehara, Eisuke Matsushima
    • Organizer
      IEEE EMBC 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Individuality Reduction in Heart Rate Variability for Drowsy Driving Detection2016

    • Author(s)
      Koichi Fujiwara, Erika Abe, Toshitaka Yamakawa, Manabu Kano
    • Organizer
      IEEE EMBC 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Missing RRI Interpolation for HRV Analysis Using Locally-Weighted Partial Least Squares Regression2016

    • Author(s)
      Keisuke Kamata, Koichi Fujiwara, Toshitaka Yamakawa, Manabu Kano
    • Organizer
      IEEE EMBC 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wakefulness Keeping Support System for Drivers Based on Game Using Body Movement and Voice Input Command2016

    • Author(s)
      Toshihiro Hiraoka, Ibe Tatsuro, Erika Abe, Koichi Fujiwara, Toshitaka Yamakawa
    • Organizer
      IEEE EMBC 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Accuracy Comparison of Two Microcontroller-embedded R-wave Detection Methods for Heart-rate Variability Analysis2015

    • Author(s)
      Toshitaka Yamakawa, Ryunosuke Kinoshita, Koichi Fujiwara, Manabu Kano, Miho Miyajima, Tadashi Sakata, Yuichi Ueda
    • Organizer
      APSIPA ASC 2015
    • Place of Presentation
      Hong Kong
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Heart Rate Monitoring by Pulse Sensor Embedded Game Controller2015

    • Author(s)
      Erika Abe, Hiroshi Chigira, Koichi Fujiwara, Toshitaka Yamakawa, Manabu Kano
    • Organizer
      APSIPA ASC 2015
    • Place of Presentation
      Hong Kong
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of NIRS Probe based on LED Sensing That Enables Multimodal Integration2015

    • Author(s)
      Shun Esaki, Toshitaka Yamakawa, Masatsugu Niwayama
    • Organizer
      IEEE EMBC 2015
    • Place of Presentation
      Milan
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epileptic Seizure Prediction based on Multivariate Statistical Process Control of Heart Rate Variability2015

    • Author(s)
      Miho Miyajima, Koichi Fujiwara, Erika Abe, Yoko Suzuki, Yuriko Sawada, Toshitaka Yamakawa, Manabu Kano, Taketoshi Maehara, Katsuya Ohta, Taeko Sasai-Sakuma,Tetsuo Sasano, Masato Matsuura, Eisuke Matsushima
    • Organizer
      IEEE EMBC 2015
    • Place of Presentation
      Milan
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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