Multimodal Assesment for Neurosurgical Diseases Employing Simultaneous Measurement of ECoG, Hemodynamics, and Temperature Destribution
| Project/Area Number |
15H05356
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Research Collaborator |
Suzuki Michiyasu
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Keywords | マルチモダリティセンサ / 生体埋込型デバイス / フレキシブル回路 / マルチモダリティ脳計測 / NIRS / ECoG / 皮質温度分布 / 電子デバイス・機器 / 脳・神経 / 先端機能デバイス |
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| Outline of Final Research Achievements |
The development of a flexible multi-modal multi-channel probe for the simultaneous measurement of the NIRS, ECoG, and surficial temperature obtained from the cerebral cortex was carried out. Photoelectric bare chips for NIRS channels, miniature temperature-coefficient thermistors for measuring localized temperature variation, and 3-mm-diameter platinum plates for ECoG recording were assembled on a polyimide-based flexible printed circuit to create six channels for each modality. A conformal coating of Parylene-C was applied on all the channels except the ECoG to make the probe surface biocompatible. Results: As a first-in-human study, the simultaneous measurement capability of the multi-modality probe, with sufficient signal-to-noise (S/N) ratio and accuracy, to observe pathological neural activities in subjects during surgery and post-operative monitoring, with no complications two weeks since the implantation, was confirmed.
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| Academic Significance and Societal Importance of the Research Achievements |
臨床上の有用性が証明されている脳活動に関わる3種の情報を、一つのデバイスで同時に得る点に特徴があり、より多面的で信頼性の高い脳活動評価法の基盤的技術となり得る。提案手法は、難治性てんかんの術前・術中診断や、動脈瘤手術後の脳虚血・過還流に伴う脳血管攣縮の診断などには直接応用可能で、現行手法(硬膜下電極の慢性留置)と同等以下の侵襲でより信頼性の高い臨床診断材料が得られる。また、脳外科領域で近年注目されている病態である皮質拡延性抑制を継続的・多面的・定量的に観測する現状唯一の手立てとなることを示した。これらの成果は電子工学だけでなく臨床医学や基礎医学などの他分野の発展にも連鎖反応的に寄与し得る。
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Report
(5 results)
Research Products
(34 results)
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[Journal Article] Epileptic Seizure Prediction Based on Multivariate Statistical Process Control of Heart Rate Variability Features2015
Author(s)
K. Fujiwara, M. Miyajima, T. Yamakawa, E. Abe, Y. Suzuki, Y. Sawada, M. Kano, T. Maehara, K. Ohta, T. Sasai-Sakuma, T. Sasano, M. Matsuura, and E. Matsushima
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Journal Title
IEEE Transactions on Biomedical Engineering
Volume: PP(99)
Issue: 6
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Real-Time Epileptic Seizure Prediction System Employing a Wearable HRV Telemeter and a Smartphone2016
Author(s)
Miho Miyajima, Toshitaka Yamakawa, Koichi Fujiwara, Yuriko Sawada, Yoko Suzuki, Erika Abe, Manabu Kano, Satsuki Watanabe, Yoshiko Murata, Yutaka Watanabe, Taketoshi Maehara, Eisuke Matsushima
Organizer
IEEE EMBC 2016
Related Report
Int'l Joint Research
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[Presentation] Epileptic Seizure Prediction based on Multivariate Statistical Process Control of Heart Rate Variability2015
Author(s)
Miho Miyajima, Koichi Fujiwara, Erika Abe, Yoko Suzuki, Yuriko Sawada, Toshitaka Yamakawa, Manabu Kano, Taketoshi Maehara, Katsuya Ohta, Taeko Sasai-Sakuma,Tetsuo Sasano, Masato Matsuura, Eisuke Matsushima
Organizer
IEEE EMBC 2015
Place of Presentation
Milan
Year and Date
2015-08-25
Related Report
Int'l Joint Research
