Neuro-rehabilitation for neurological disorders caused by overuse

• Project/Area Number: 15H05358
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Sophia University
• Principal Investigator: FURUYA Shinichi 上智大学, 音楽医科学研究センター, 特任准教授 (20509690)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
• Keywords: 経頭蓋直流電気刺激 / ニューロリハビリテーション / ジストニア / 巧緻運動機能 / 局所性ジストニア / ニューロフィードバック / 非侵襲脳刺激 / 脳神経可塑性 / 介入 / 経頭蓋磁気刺激 / バイオマーカー / 局所神経回路異常 / 運動器疾患 / シナジー / 巧緻性

Outline of Final Research Achievements

The present study assessed both fine motor control and excitability of the primary motor cortex before and after the intervention that combined the bi-hemispheric transcranial direct current stimulation (tDCS) and bimanual mirrored finger movements. We also found a relationship between the abnormality of excitability of the motor cortex and degradation of motor dexterity by combining neurophysiological and behavioral experiments with machine learning. Finally, the intervention over successive days showed progressive restoration of the motor abnormality.

Research Products

• [Int'l Joint Research] ハノーファー音楽演劇大学(ドイツ)
• [Int'l Joint Research] ハノーファー音楽演劇大学(ドイツ)
• [Int'l Joint Research] ハノーファー音楽演劇大学/ゲッティンゲン大学/ライプニッツ研究所(ドイツ)
• [Journal Article] Aberrant cortical excitability reflects the loss of hand dexterity in musician's dystonia (2018)
  • Author(s): Furuya Shinichi、Uehara Kazumasa、Sakamoto Takashi、Hanakawa Takashi
  • Journal Title: The Journal of Physiology Volume: in press Issue: 12 Pages: 2397-2411
  • DOI: 10.1113/jp275813
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ジストニアの脳内機序①機能画像 (2017)
  • Author(s): 古屋晋一
  • Journal Title: Modern Physician Volume: 37(6) Pages: 580-582
• [Journal Article] A curse of motor expertise: focal task-specific dystonia as manifestation of maladaptive changes in body representations (2016)
  • Author(s): Furuya S and Hanakawa T
  • Journal Title: Neurosci Res Volume: 104 Pages: 112-119
  • DOI: 10.1016/j.neures.2015.12.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The impact of stress on motor performance in skilled musicians suffering from focal dystonia: Physiological and psychological characteristics (2016)
  • Author(s): Christos Ioannou, Shinichi Furuya, Eckart Altenmuller
  • Journal Title: Neuropsychologia Volume: 85 Pages: 226-236
  • DOI: 10.1016/j.neuropsychologia.2016.03.029
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Quantification of sound instability in embouchure tremor based on the time varying fundamental frequency. (2016)
  • Author(s): Lee A, Voget J, Furuya S, Morise M, Altenmuller E
  • Journal Title: Journal of Neural Transmission Volume: 印刷中 Issue: 5 Pages: 515-521
  • DOI: 10.1007/s00702-016-1533-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Brain plasticity and the concept of metaplasticity in skilled musician (2016)
  • Author(s): Eckart Altenmuller, Shinichi Furuya
  • Journal Title: Advances in Experimental Medicine and Biology Volume: 957 Pages: 197-208
  • DOI: 10.1007/978-3-319-47313-0_11
  • ISBN: 9783319473123, 9783319473130
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Objective evaluation of performance stress in musicians with dystonia: A feasibility study (2016)
  • Author(s): Ioannou CI, Furuya S, Altenmuller E
  • Journal Title: Journal of Motor Behavior Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Acquisition and reacquisition of motor coordination in musicians. (2015)
  • Author(s): Furuya S, Altenmuller E
  • Journal Title: Annals of the New York Academy of Sciences Volume: 1337 Issue: 1 Pages: 118-124
  • DOI: 10.1111/nyas.12659
  • Peer Reviewed
• [Journal Article] Losing dexterity: patterns of impaired coordination of finger movements in musician’s dystonia (2015)
  • Author(s): S. Furuya, K. Tominaga, F. Miyazaki, E. Altenmuller
  • Journal Title: Scientific Reports Volume: 5(13360） Issue: 1 Pages: 1-14
  • DOI: 10.1038/srep13360
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Secrets of virtuoso: neuromuscular attributes of motor virtuosity in expert musicians (2015)
  • Author(s): S. Furuya, T. Oku, F. Miyazaki, H. Kinoshita
  • Journal Title: Scientific Reports Volume: 5(15750) Issue: 1 Pages: 1-8
  • DOI: 10.1038/srep15750
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Metaplasticity of sensory-motor integration in musicians (2017)
  • Author(s): Shinichi Furuya
  • Organizer: Neurosciences and Music
  • Int'l Joint Research
• [Presentation] 音楽家のための科学技術の未来：医工芸の相乗効果を生み出す音楽医科学の確立を目指して (2017)
  • Author(s): 古屋晋一
  • Organizer: 日本電子キーボード音楽学会
  • Invited
• [Presentation] 音楽医科学：医工芸連携による音楽家のQOL向上を目指して (2017)
  • Author(s): 古屋晋一
  • Organizer: 計測自動制御学会（SICE）自動制御連合講演会
  • Invited
• [Presentation] Transcranial Brain Stimulation in Musicians’ Dystonia (2016)
  • Author(s): Shinichi Furuya
  • Organizer: International Congress on Treatment of Dystonia
  • Place of Presentation: ハノーファー，ドイツ
  • Year and Date: 2016-05-04
  • Int'l Joint Research / Invited
• [Presentation] Abnormalities of the finger movements in musician’s dystonia. (2015)
  • Author(s): Furuya S, Tominaga K, Miyazaki F, Altenmuller E
  • Organizer: Society for Neuroscience
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2015-10-16
  • Int'l Joint Research
• [Presentation] White matter changes in pianists with focal hand dystonia. (2015)
  • Author(s): Kita K, Uehara K, Furuya S, Osu R, Sakamoto T, Hanakawa T
  • Organizer: Society for Neuroscience
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2015-10-16
  • Int'l Joint Research
• [Presentation] Non-invasive brain stimulation for altering performance of musicians: Studies in healthy volunteers, and dystonia patients. (2015)
  • Author(s): Furuya S, Nitsche MA, Paulus W, Altenmuller E
  • Organizer: The 9th ICME Conference on Complex Medical Engineering (ICME)
  • Place of Presentation: 岡山コンベンションセンター（岡山県・岡山市）
  • Year and Date: 2015-06-19
  • Int'l Joint Research / Invited
• [Book] Treatment of Dystonia (2018)
  • Author(s): Eckart Altenmuller, Shinichi Furuya
  • Total Pages: 4
  • Publisher: Cambridge University Press
  • ISBN: 9781316459324
• [Book] Oxford Handbook of Music Psychology (2016)
  • Author(s): Eckart Altenmuller, Shinichi Furuya
  • Publisher: Oxford University Press
• [Book] Progress in Motor Control: Theories and Translations (2016)
  • Author(s): Eckart Altenmuller, Shinichi Furuya
  • Publisher: Springer
• [Remarks] 音楽医科学研究センター
  • URL: http://neuropiano.wix.com/music
• [Remarks] 経頭蓋電気刺激法の生理学的機序と機能的意義
  • URL: https://sites.google.com/site/musicnibs2015/
• [Funded Workshop] 経頭蓋電気刺激法の生理学的機序と機能的意義 (2015)
  • Place of Presentation: 上智大学，音楽医科学研究センター
  • Year and Date: 2015-11-08