Effects of robot training and noninvasive brain stimulation on the motor and cognitive functions of stroke patients

• Project/Area Number: 15H05359
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Fujita Health University
• Principal Investigator: Takeda Kotaro 藤田医科大学, 保健学研究科, 准教授 (50618733)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000); Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
• Keywords: ロボット / リハビリテーション / ロボットリハビリテーション / 感覚障害 / ロボット・リハビリテーション / fNIRS / 電気刺激 / 脳・神経 / 医療・福祉

Outline of Final Research Achievements

We constructed evidence about robot rehabilitation and brain stimulation in stroke rehabilitation. (1) Neuromuscular electrical stimulation during robotic training might facilitate the activation of paretic muscles, resulting in paralysis improvement. (2) Sensory impairment was one of the factors that reduced the effect of robot rehabilitation. (3) Anodal transcranial direct current stimulation over the left temporoparietal area improved audioverbal memory performance after stroke. (4) In addition, retrospective studies showed that damage to the posterior limb of the internal capsule and cognitive function evaluation using the Raven's Colored Progressive Matrices test might be useful for predicting the outcome of motor paralysis and activities of daily living in patients with putaminal hemorrhage.

Academic Significance and Societal Importance of the Research Achievements

脳卒中後には運動機能や認知機能などさまざまな障害が残り，これらの障害を改善することがリハビリテーションの目的のひとつである．近年，ロボット訓練や非侵襲電気刺激といった新しいリハビリ法が数多く提案されているが，エビデンスが不足しているのが問題のひとつであった．そこで本研究では，電気刺激と上肢訓練ロボットの併用効果や，麻痺改善を阻害し得る感覚障害がロボット訓練効果へ与える影響を明らかにすることで，より臨床場面に即した状況における応用に関するエビデンスを提供するに至った．

Research Products

• [Journal Article] Relationship between Hematoma Volume and Motor Impairment in Putaminal Hemorrhage (2020)
  • Author(s): Ohnishi Hitoshi、Takeda Kotaro、Watanabe Makoto、Maeshima Shinichiro、Sonoda Shigeru
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 29 Issue: 6 Pages: 104812-104812
  • DOI: 10.1016/j.jstrokecerebrovasdis.2020.104812
  • Peer Reviewed
• [Journal Article] Effect of Sensory Loss on Improvements of Upper-Limb Paralysis Through Robot-Assisted Training: A Preliminary Case Series Study (2019)
  • Author(s): Miyasaka Hiroyuki、Takeda Kotaro、Ohnishi Hitoshi、Orand Abbas、Sonoda Shigeru
  • Journal Title: Applied Sciences Volume: 9 Issue: 18 Pages: 3925-3925
  • DOI: 10.3390/app9183925
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hemodynamic responses in prefrontal cortex and personality characteristics in patients with bulimic disorders: a near-infrared spectroscopy study. (2018)
  • Author(s): Numata N, Hirano Y, Sutoh C, Matsuzawa D, Takeda K, Setsu R, Shimizu E, Nakazato M.
  • Journal Title: Eat Weight Disord, in press Volume: - Issue: 1 Pages: 1-9
  • DOI: 10.1007/s40519-018-0500-7
  • Peer Reviewed
• [Journal Article] Transcranial direct current stimulation improves audioverbal memory in stroke patients (2017)
  • Author(s): Kazuta T, Takeda K, Osu R, Tanaka S, Oishi A, Kondo K, Liu M
  • Journal Title: Am J Phys Med Rehabil Volume: - Issue: 8 Pages: 565-571
  • DOI: 10.1097/phm.0000000000000686
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ability of electrical stimulation therapy to improve the effectiveness of robotic training for paretic upper limbs in patients with stroke (2016)
  • Author(s): Miyasaka H, Orand A, Ohnishi H, Tanino G, Takeda K, Sonoda S.
  • Journal Title: Med Eng Phys Volume: 38 Issue: 11 Pages: 1172-1175
  • DOI: 10.1016/j.medengphy.2016.07.010
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reduction of global interference of scalp-hemodynamics in functional near-infrared spectroscopy using short distance probes (2016)
  • Author(s): Sato T, Nambu I, Takeda K, Aihara T, Yamashita O, Isogaya Y, Inoue Y, Otaka Y, Wada Y, Kawato M, Sato MA, Osu R
  • Journal Title: Neuroimage Volume: 141 Pages: 120-132
  • DOI: 10.1016/j.neuroimage.2016.06.054
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Development of a simple device for assessment of spasticity (2017)
  • Author(s): Takeda K, Maeda H, Sonoda S
  • Organizer: The 47th Annual Meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] 上肢ロボットのアシスト量からみる麻痺側上肢の重症度別の麻痺回復過程の違い (2017)
  • Author(s): 宮坂裕之, 武田湖太郎, 大西斉, Orand A, 園田茂
  • Organizer: 第51回日本作業療法学会
• [Presentation] 機能的近赤外分光法（fNIRS）の基礎と実践 (2016)
  • Author(s): 武田湖太郎
  • Organizer: 第23回脳機能とリハビリテーション研究会 学術集会 教育セミナー
  • Place of Presentation: 千葉県立保健医療大学 幕張キャンパス（千葉市美浜区）
  • Year and Date: 2016-04-24
  • Invited
• [Presentation] 機能的近赤外分光法（fNIRS）の原理と実践 (2015)
  • Author(s): 武田湖太郎
  • Organizer: 第22回脳機能とリハビリテーション研究会 学術集会
  • Place of Presentation: 千葉県立保健医療大学 幕張キャンパス（千葉市美浜区）
  • Year and Date: 2015-04-12
  • Invited